Biomedical subjects
Publications and source records attributed to J M Gottswinter.
Parathyroid carcinoma, as a malignant tumour of an endocrine gland, is a rare entity. This causes difficulties in the diagnosis as well in the therapeutic approach. Some clinical courses of this malignant disease are demonstrated. The therapeutic options--surgically and medically--are reported and analysed.
The parathyroid carcinoma is a rare cause of primary hyperparathyroidism. It deserves special attention in regard to diagnosis and treatment. Within a period of 10 years we observed 117 patients with primary hyperparathyroidism (pHPT) at the University Hospitals of Ulm and Heidelberg. In five patients a parathyroid carcinoma was found, corresponding to an incidence of 4.4%. In four of five patients no clinical signs were evident preoperatively indicating a parathyroid malignancy.
Two men at the age of 48 and 54 yr developed gynecomastia and lost their potency after the use of estrogen containing hair lotions. During exposure to the lotion the levels of 17-beta estradiol were increased, whereas the levels of testosterone and gonadotropins were depressed. Thus, a previous application of such hair lotions should be considered in the differential diagnosis of gynecomastia.