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J M Goujon

Publications and source records attributed to J M Goujon.

At least 55 records · Page 3Linked to original sources
PubMed1997

[Pathological anatomy of primary cerebral lymphoma].

In this retrospective study (1986-1996), a series of 250 immunocompetent patients (SFNC series) with primary malignant lymphoma of the central nervous system is reviewed and the lymphomas redefined using the REAL (Revised European-American classification of Lymphoid neoplasms) and the modified Kiel classifications. All the tumors available for review were classic diffuse non-Hodgkin's lymphomas. Thirty-eight were unclassifiable due to small size and artifacts in the specimens. Eight cases were of T-cell type (3.7%). The 212 others cases were B-cell type. According to the REAL classification, the high majority was diffuse large cell (62%). Following the modified Kiel classification percentage of cases categorized as low and high grade of malignancy were 22.4% and 77.6% respectively.

Brain Neoplasms↗
PubMed1996

Renal involvement in Behçet's disease. Case report and review of the literature.

A female patient has suffered from Behçet's disease (BD) for 15 years. During one recurrent episode proteinuria and microscopic hematuria were discovered. Renal biopsy revealed focal segmental glomerulopathy with IgA deposits. Renal involvement in BD is uncommon and includes amyloidosis, crescentic glomerulonephritis and IgA nephropathy. BD is a cause of secondary IgA nephropathy. Immunologic features of the two diseases, particularly increased serum IgA, are reviewed.

Behcet Syndrome↗
PubMed1996

[Compression of the peroneal nerve by a synovial cyst in a 7-year-old child].

PURPOSE OF THE STUDY: Compressions of the peroneal nerve by synovial cysts are rare. Sixty cases have been described since 1921. MATERIALS AND METHODS: It concerns extrinsic compression of the peroneal nerve by a synovial cyst, developed from the upper tibiofibular joint, in a seven years old child. As far as we know, this is the youngest age found in the relevant literature. Because of a swiftly appearing painful swelling, along with complete paralysis of the peroneal nerve, an electromyogram and a magnetic resonance imaging were performed, in view to confirm the diagnosis and to clarify cyst topography. RESULTS: Removal of the cyst led to healing with complete recovery of the peroneal nerve within three months. DISCUSSION: Both intraneural and extraneural cysts exist. Most authors agree that their source is the upper tibiofibular joint. In case of intraneural cysts, complete removal is sometimes impossible. It seems preferable to make a longitudinal incision in the nerve to lay the tumor flat. Indeed, everything possible should be done to find, then ligature, the pedicle which passes by the articular nerve ending of the peroneal nerve in order to avoid recurrence. Extraneural cysts are sometimes intra- or inter-muscular and create a swelling which is often palpable. It is necessary to remove the cyst carefully and to dissociate it from the nerve endings. CONCLUSION: In all cases, recurrence is not infrequent. Longer the delay before intervention is less satisfactory the recovery will be.

Child↗
PubMed1995

Cathepsin D in normal and neoplastic thyroid tissues.

BACKGROUND: Cathepsin D is a widely distributed lysosomal acidic endopeptidase. It is an estrogen-regulated protein that is a prognostic factor in breast cancer. The aim of this study was to measure cathepsin D concentrations in thyroid tissues and to correlate these concentrations with clinical and pathologic parameters. METHODS: Cathepsin D and thyroglobulin concentrations were measured in the cytosol of normal thyroid tissues (n = 14), benign nodules (n = 6), and thyroid carcinomas (n = 32) with an immunoradiometric assay. Statistical analysis was based on the Kruskal-Wallis and Wilcoxon tests and on the Spearman rank correlation coefficient. RESULTS: The mean level of cathepsin D, expressed as picomoles per milligram protein minus thyroglobulin, was higher in the 32 carcinomas, 29.1 +/- 15.5, than in the 14 normal thyroid tissues, 8.4 +/- 2.5 (p < 0.001) or in the 6 benign nodules, 11.2 +/- 7.3 (p = 0.003). Cathepsin D concentrations correlated with tumor size; Spearman rank correlation coefficient was rs = 0.44 (p = 0.012). No significant difference was found regarding histologic type. Cathepsin D concentrations were inversely correlated with the thyroglobulin level in the tumor; Spearman rank correlation coefficient was rs = -0.60 (p < 0.001). CONCLUSIONS: Cathepsin D concentration is higher in thyroid carcinoma than in normal thyroid tissue. Increased cathepsin D concentrations correlate with thyroid tumor size but not with histologic type. Further studies should be done to confirm the potential prognostic value of cathepsin D in patients with thyroid carcinomas.

Adult↗
PubMed1995

[Metacarpal aneurysmal cysts. Report of two cases and review of the literature].

The authors present two cases of aneurysmal cyst, one primary and one secondary. The first case was treated surgically by resection and bone graft. The second case, associated with a giant cell tumors, was initially treated surgically by resection and bone graft, but, because of a rapid recurrence of the giant cell tumor, the middle finger had to be amputated. The clinical, radiological and histopathological features of aneurysmal cyst are recalled. The various therapeutic modalities recalled and their value in this particular site are discussed.

Adolescent↗
PubMed1994

Immunocytochemical localisation of hydroxyindole-O-methyltransferase in pineal photoreceptor cells of several fish species.

Melatonin is an internal "Zeitgeber," involved in the timing and control of a number of rhythmic functions and behaviours. Its synthesising cells remain to be identified in the fish pineal. The last step in the melatonin biosynthetic pathway is catalysed by the enzyme hydroxyindole-O-methyltransferase. An affinity-purified antibody, directed against chicken pineal hydroxyindole-O-methyltransferase, was used in the present study to identify the melatonin synthesising cells in four fish species: a primitive chondrostean (sturgeon), a saltwater teleost (dorado), and two freshwater teleosts (pike, trout). Western blot immunolabeling of pike and trout pineal proteins revealed a single band at 38 KDa, which corresponds to the known molecular weight of the enzyme in bovine, rat, and chicken pineal. Regardless of the species, a specific immunocytochemical labeling, visualised by means of the peroxidase-antiperoxidase method, was exclusively associated with the photoreceptor cells. These results provide evidence that photoreceptors of the fish pineal are responsible for the biosynthesis of 5-methoxyindoles, including melatonin. In the pike, reactions were less intense in the distal portion of the pineal vesicle than in the other regions of the organ. It is questioned whether this might be related to the existence of a germinative zone, generating new photoreceptor cells in this distal portion. Hydroxyindole-O-methyltransferase has been previously demonstrated in mammalian pinealocytes, and modified photoreceptors of the avian pineal. It is now demonstrated in pineal photoreceptors of a primitive fish and of more evolved saltwater and freshwater fish. The results strengthen the view that these cells are related through phylogeny and that their well conserved melatoninergic function appears early in the course of evolution.

Acetylserotonin O-Methyltransferase↗
PubMed1994

Prognostic value of histological grade and nuclear grade in renal adenocarcinoma.

We conducted a retrospective study of 237 cases of clinically localized renal adenocarcinoma treated at our department between November 1971 and December 1991 by radical nephrectomy. The parameters considered were tumor extension (pT stage), histological grading and nuclear grading. If the histological grade proved to be of little informational value in regard to survival, nuclear grade and pT stage had significant impact. On the other hand, nuclear grading considered in a given stage provided no significant influence. We conclude that nuclear grading cannot predict the outcome of patients at the same surgical stage.

Adenocarcinoma↗
PubMed1994

[Vitelline tumor: a rare tumor of the mediastinum].

A young patient presented with a rare tumour of the mediastinum. The first sign was liquid effusion in the right hemithorax. A major rise in alpha-foeto-protein level to 34,000 ng/ml rapidly led to diagnosis. Histological confirmation was obtained on a surgical biopsy specimen of the lung. Management included primary polychemotherapy followed by complete surgical exeresis. A second post-operative cycle of chemotherapy was given but only led to temporary normalization of alpha-foeto-protein levels and intensive chemotherapy followed by autograft to peripheral stem cells was performed. The vitellin tumour is a primary germ cell tumour usually observed in young men. It originates in extraembryonary primary mesenchymal tissue. Like other germ cell tumours, the diagnosis should be entertained for all tumours of the anterior mediastinum. Tumour markers useful for diagnosis and prognosis are beta-HCG, AFP and CEA. Levels above 500 ng/ml confirm vitellin tumour. Chemotherapy should be instituted rapidly using a BEP protocol (bleomycine, etoposide, cisplatinium) or a PVB protocol (cisplatinium, vinblastin, bleomycine). Using these new drugs and current therapeutic protocols, the rate of complete remission has risen from 13% to 40%.

Adult↗
PubMed1994

Endoscopic approach of the pterygopalatine fossa: report of one case.

We report one case of schwannoma of the pterygopalatine fossa. The pre-operative management and post-operative follow-up are presented. For this uncommon localization, we propose an endoscopic approach via the nasal fossa and the maxillary sinus. The advantages and limitations of this technique are discussed.

Endoscopy↗
PubMed1994

[Immature teratoma of the ovary. Apropos of 3 cases. Review of the literature and an evaluation].

Immature teratoma of the ovary is a rare tumour (1% of cancer of the ovary) usually seen in adolescents or young women. It is a malignant tumour derived from an abnormal germ-cell which undergoes meiotic division. The diagnosis is based on the pathological examination which reveals immature tissue derived from two or three types of embryonic tissue (endo-, meso- and ectoderm). Intraperitoneal dissemination occurs and immature or mature recurrence is observed. The prognosis was particularly severe before the use of polychemotherapy which has also made conservative surgery possible. At the present time, the consensus is to reduce the duration of the chemotherapy with a regular clinical and laboratory (tumour markers, aFP) monitory. A second look laparotomy verifies successful treatment.

Adolescent↗
PubMed1994

[Benign pelvic schwannoma. A case report].

A rare case of benin pelvic schwannoma was observed fortuitously during normal echographic follow-up of a cyst of the ovary. The usually silent tumours are difficult to diagnose. Computed tomography appears to be the most informative examination concerning the nature of these tumours and their relations with the surrounding structures. Nevertheless, the exact nature cannot be determined before curative surgical exeresis and pathology examination. The risk of relapse is extremely small, but does exist, justifying follow-up.

Aftercare↗
PubMed1993

[Nasosinusal schwannoma. Apropos of 2 cases. Value of nasal endoscopy for diagnosis and treatment].

Two cases of paranasal schwannomas are reported. These tumors are rare. Its symptomatology is no specific explaining the late diagnosis. The contribution of radiology and endoscopy for this pathology is analysed. Ct scan and MRI state precisely the extension and the relations of the tumor. Endoscopy improves the endonasal exam pre and post operative and may be an option for the surgical treatment of these tumors. In connection with that we present an original approach of the pterygopalatine fossa under endoscopic control via the middle meatus.

Adult↗