PubMed Health⌕ Search

Biomedical subjects

J M Guy

Publications and source records attributed to J M Guy.

At least 19 recordsLinked to original sources
PubMed1992

[Cerebral abscess disclosing congenital heart disease].

Cerebrovascular accidents and brain abscesses are the most worrisome complications of cyanogenic cardiac lesions in infants and young children, but remain rare in the adult. The authors report the case of a brain abscess which led to the subsequent discovery of a congenital cardiac malformation consisting of a ventricular septal defect and moderate pulmonary valve stenosis. Complete correction of the cardiac lesions was carried out three months after neurosurgical treatment (needle biopsy/drainage).

Brain Abscess↗
PubMed1992

Serum creatinine assays in patients receiving the antibiotic Cefpirome (HR 810): a study of three different routine methods compared with a specific HPLC method.

Sequential timed samples were taken from patients after a single dose of a new cephalosporin--Cefpirome HR810. The patients had been recruited in a multi-centre trial over a 12-month period. Creatinine was estimated in all of these specimens by four different techniques, embodying four different analytical principles. Interference from the drug was evident in the assay depending on the Jaffe reaction. There was also interference in the enzyme-based methods, manifested as increased imprecision due to a non-specified cause thought to be related to the age of the samples. Only the HPLC method guaranteed precise results free from drug interference.

Cephalosporins↗
PubMed1992

[Spontaneous angina caused by spasm of the left coronary artery].

A 42 year old woman presented with a one year history of retrosternal chest pain and back pain on effort and at rest sometimes accompanied by minor syncopal attacks. Transient atrioventricular block was documented during one such episode associated with hypotension. Coronary angiography showed spontaneous spasm of the left main coronary artery with clinical symptoms but no electrocardiographic changes. The spasm was relieved by injection of SIN-1. The similarity between the previous clinical symptoms and those observed at coronary angiography was in favour of the diagnosis of spasm of the left main coronary artery without atherosclerotic coronary disease. Treatment with calcium atherosclerotic coronary disease. Treatment with calcium blockers and platelet antiaggregants led to total regression of her symptoms with a follow-up of 5 months.

Adult↗
PubMed1991

[Torsades de pointes and prolongation of the duration of QT interval after injection of droperidol].

Following a case of torsades de pointe (TDP) after the injection of droperidol (D), the authors studied the electrocardiographic variations caused by the drug. Fifty five unselected patients under the same conditions (general anesthesia) were given D (0.25 mg/kg IV). Significant prolongation of the QT interval was seen in 70% of cases by the end of the first minute. QT interval and the ratio of QTm (measured) over QTt increased from 387 +/- 34 ms to 423 +/- 37 ms (p less than 0.0001) and from 1.06 +/- 0.08 to 1.28 +/- 0.1 (p less than 0.001) respectively. These changes could favourise the onset of TDP. Although exceptional in terms of the extensive use of the neuroleptic in question, this possibility indicates the need for monitoring of the duration of QT before and during treatment with droperidol and for prescription of the drug to be avoided in circumstances known to be propitious to this arrhythmia (bradycardia, hypokalemia, anti-arrhythmic drugs).

Adult↗
PubMed1991

[Spontaneous calcified coronary embolism and myocardial infarction. Apropos of a case].

The authors report a rare case of myocardial infarction due to calcific coronary embolisation in a patient with previously asymptomatic calcific aortic stenosis. The diagnosis was suggested by the finding of a lacunar image in the distal segment of the left anterior descending artery exactly corresponding to a punctiform mobile calcification visible before opacification of the coronary arteries. The clinical features of coronary embolism and in particular of calcific embolism are reviewed.

Aortic Valve Stenosis↗
PubMed1991

[Surgery without catheterization of aortic coarctation in newborn infants and infants under 3 years of age].

A retrospective study of 150 children under 3 months of age who underwent repair of coarctation of the aorta in the same center (between 1972 and 1987) was undertaken to assess the problems posed by surgery without cardiac catheterisation or angiography. The patients were divided into two groups: Group A, comprising 104 children operated after invasive investigations, and Group B, comprising 46 children operated on Doppler echocardiographic data alone. The two populations were comparable and "hypoplastic aortic arch" type coarctation was present in over 60% of cases. However, there were more ventricular septal defects in Group B (67.5%) than in Group A (49%). There were no significant diagnostic errors in Group B (one case of interrupted aortic arch diagnosed at surgery). The 1 month survival was the same in the two groups (82%). The indications of pulmonary artery banding were less frequent in Group B although there were more ventricular septal defects in these patients. These results confirm the value of Doppler echocardiography in the context of urgent surgery of congenital heart disease.

Angiocardiography↗
PubMed1990

An improved cation exchange HPLC method for the measurement of serum creatinine.

An improved HPLC method for the measurement of serum creatinine is described. Separation is effected using a strong cation exchange column at pH 4.7. Analytical recovery, precision and linearity are satisfactory, and the method correlates well with a kinetic Jaffé procedure. The method provides a means of accurately measuring creatinine and may be of use in the investigation of interference in creatinine assays.

Chromatography, High Pressure Liquid↗
PubMed1989

[Echography and scintigraphy using technetium 99m pyrophosphate in the diagnosis of cardiac amyloidosis].

The diagnosis of amyloid cardiomyopathy was only based, until the last few years, on the results of invasive techniques. It seems presently that the combined contribution of cardiac sonography and scintigraphy using technetium 99m pyrophosphate, makes, most of the time, this diagnosis possible without need for additional examinations. This notion is illustrated by a typical case-report and data from the literature. Demonstration on the cardiac sonogram of a thickening of the walls-while the context and especially the electrocardiogram are not in favor of a left ventricular hypertrophy--associated with a very particular "hyperechoing" aspect and an abnormal fixation on the scintigram, may be considered specific of this disease.

Amyloidosis↗
PubMed1988

[Evaluation of surgical renal revascularization in renovascular arterial hypertension. Measurement by 99m Tc DTPA scintigraphy].

The effects of surgical renal revascularization on both hypertension and kidney function was assessed in 16 patients with renovascular hypertension (14 unilateral). We have taken a special interest to the split renal function studied with DTPA renogram. The function of the operated kidney was improved in 9 patients and not improved (worsened or unchanged) in 7. Hypertension was cured in 25% and improved in 56% of the patients, without correlation with split renal function outcome.

Adult↗