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Biomedical subjects

J M Jonas

Publications and source records attributed to J M Jonas.

44 records · Page 3Linked to original sources
PubMed1983

Bulimia treated with imipramine: a placebo-controlled, double-blind study.

Bulimia, the syndrome of compulsive binge eating, is a common and often severe disorder frequently resistant to known therapies. Recent evidence suggesting a link between bulimia and affective disorder prompted the authors to perform a double-blind study of imipramine versus placebo with 22 chronically bulimic women. Imipramine was associated with a significantly reduced frequency of binge eating and with improvement on several other measures of eating behavior. On 1- to 8-month follow-up, 18 of the 20 treated subjects (90%) had responded to imipramine or a subsequent antidepressant. This finding augments the growing evidence that bulimia may be related to affective disorder.

Adolescent↗
PubMed1983

Family history study of anorexia nervosa and bulimia.

The 420 first-degree relatives of 14 patients with anorexia nervosa, 55 patients with bulimia, and 20 patients with both disorders were evaluated for the presence of psychiatric illness, using DSM-III criteria, by the family history method. The morbid risk for affective disorder in the families of the eating disorder probands was similar to that found in the families of patients with bipolar disorder; but was significantly greater than that found in the families of patients with schizophrenia or borderline personality disorder. These results add to the growing evidence that anorexia nervosa and bulimia are closely related to affective disorder.

Adolescent↗
PubMed1983

Antidepressant treatment of bulimia: preliminary experience and practical recommendations.

Bulimia--the syndrome of compulsive binge-eating--often proves refractory to standard therapeutic techniques. However, several recent uncontrolled reports and one placebo-controlled study have suggested that bulimia may often respond to antidepressant medications. The present report amplifies on the existing literature with data from 65 consecutive bulimic patients treated with a variety of antidepressants, and offers practical recommendations for pharmacological treatment of bulimia, derived from experience in our center.

Ambulatory Care↗
PubMed1982

Factitious psychosis: phenomenology, family history, and long-term outcome of nine patients.

Factitious psychological symptoms are defined in DSM-III as symptoms that are under the patient's voluntary control. Using specific criteria for the presence of voluntary control, the authors identified a cohort of 9 patients with factitious psychotic symptoms from among 219 patients consecutively admitted to a research ward for psychotic disorders. The phenomenology and family history of the patients suggested that they were a homogeneous group. All had similar DSM-III personality disorders, and most had a remarkably poor long-term outcome.

Adult↗
PubMedDate not supplied

Treatment of antidepressant-resistant bulimia with naltrexone.

Ten individuals with antidepressant-resistant bulimia were treated with the long-acting opiate antagonist naltrexone. Seven of the ten experienced at least a 75 percent reduction of their bulimic symptoms, and have maintained their improvement on three to five month follow-up. These preliminary data suggest that naltrexone may be of use in bulimia unresponsive to standard antidepressant therapy, and may provide insight into the role of endogenous opioids in the etiology of eating disorders.

Adolescent↗