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Biomedical subjects

J M Kidd

Publications and source records attributed to J M Kidd.

13 recordsLinked to original sources
PubMed1997

Health outcomes of women exposed to household alcohol abuse: a Family Practice Training Site Research Network (FPTSRN) study.

BACKGROUND: There is a paucity of knowledge about the effects of exposure to alcohol abuse in the household on women who do not abuse alcohol. The purpose of this study was to determine whether women who did not abuse alcohol demonstrated any health-related adverse effects because they lived with family members who did abuse alcohol. METHODS: This study was a historical prospective survey of female patients at five primary care practices. Survey instruments included the CAGE questionnaire, a five-item screening test for exposure to alcoholism, and the Medical Outcomes Study 36-item Short Form Health Survey (MOS SF-36). Patient records were examined for specific diagnoses. RESULTS: A total of 267 patients completed the questionnaires and had complete medical records available for analysis. Forty-two (15.7%) potential alcohol abusers were excluded from the sample leaving a working total of 225; 70 (31.1%) were potentially exposed to alcoholism in the household. Women exposed to alcohol abuse in the home did not experience an increased risk for the medical diagnoses studied, but they did demonstrate decreased health-related quality of life as measured by the MOS-SF-36 for the following scales: role physical (P = .025), role emotional (P = .038), social functioning (P = .001), bodily pain (P = .016), and mental health (P = .040). CONCLUSIONS: Women exposed to alcohol abuse in the household are more likely to perceive themselves as less healthy. Although they may not have received a clinical diagnosis of depression, they are more likely to feel depressed. The extent to which subjects' health-related quality of life is influenced by exposure to alcohol abuse suggests that the medical diagnosis may be insensitive as a description of health status in this population.

Adolescent↗
PubMed1984

Evidence of spinal cord injury in an infant delivered by cesarean section. A case report.

A 3-month-old female infant is reported with upper spinal cord injury at birth. Breech presentation and hyperextension of head were observed 1 week prior to delivery. She was delivered by elective cesarean section. The absence of fetal movements 1 day prior to delivery and the uneventful cesarean section strongly suggest a spinal cord injury in utero secondary to hyperextension of the neck.

Adult↗
PubMed1983

Food-dependent exercise-induced anaphylaxis.

This article describes four cases of exercise-induced anaphylaxis occurring only in temporal relationship to the ingestion of food. One individual developed anaphylaxis if exercise followed the ingestion of any food within 2 hr. Three other individuals had symptoms only if celery was ingested in relation to exercise. Skin reactivity to fresh celery extracts was demonstrated in all three individuals. The episodes were prevented by avoidance of food ingestion in relation to exercise. This syndrome appears to be a variant of exercised-induced anaphylaxis.

Adult↗
PubMed1983

Antigens of Aspergillus fumigatus. II. Electrophoretic and clinical studies.

Cell sap (CS) and culture filtrate (CF) preparations of Aspergillus fumigatus strains Ag-507, Ag-515, and Ag-534 were analysed by two dimensional electrophoresis (2-DE; i.e., first dimension isoelectric focusing, second dimension sodium dodecyl sulphate gradient pore gel), which enabled detection of strain- and species-specific components. In CS preparations it was shown that CS2, a fraction isolated from strain Ag-507 by gel filtration, consists of the major protein components in the CS of the three A. fumigatus strains tested. Culture filtrate preparations of the three A. fumigatus strains analysed by 2-DE exhibited patterns dissimilar to the CS patterns, as well as to each other, presumably due to proteolysis. Culture filtrate preparations are therefore a less reliable source of standardized antigens than CS preparations. CS2 has a major component with a mol. wt. of approximately 150,000 and an sapp of 6.3 S. CS2 reacts on immunoelectrophoresis, producing one major precipitin arc with aspergilloma or allergic bronchopulmonary aspergillosis (ABPA) patient sera. Antibody titres of the IgG and IgA classes to CS2, as measured by enzyme-linked immunosorbent assay (ELISA), were demonstrated to be similar in aspergilloma and ABPA patients; IgG titres were higher than IgA. Similar titres were also obtained utilizing sera of patients that did or did not exhibit precipitating antibodies to CS2. In the diagnosis of ABPA, skin tests with CS2 were comparable in specificity to currently available commercial preparations. Importantly, CS2 is a standardized major antigenic preparation of the CS of three A. fumigatus strains which has been shown to be diagnostically useful.

Antigens, Fungal↗
PubMed1982

Cystic nephroma: morphologic spectrum and implications.

Among 216 primary renal tumors collected from a pediatric population in metropolitan Chicago, 6 instances corresponded in multiloculated cystic masses conforming to the diagnostic criteria of so-called cystic nephroma. Histopathologically, the component tissues were entirely mature in 2 cases, but in the remaining 4 the septa between cysts contained variable amounts of primitive or embryonic tissues; in one of these, a grossly visible mass formed a nodule of typical Wilms tumor. Our experience agrees with previous reports that favor closer structural similarity of these lesions to nephroblastoma than to any known form of cystic malformation. This concept has important consequences on the therapeutic approach to preoperatively diagnosed multilocular cystic masses of the kidney, and supports the idea that nephrectomy is the treatment of choice. Metastases or local recurrence have not been reported in cases of cystic nephroma.

Child, Preschool↗
PubMed1981

Mesenchymal renal tumors in infancy: a reappraisal.

Eight cases of primary mesenchymal renal tumor in infants under one year of age were studied. The patients' ages ranged from one day to seven months; all but one were diagnosed within the first three months of life. There were four typical congenital mesoblastic nephromas. Two malignant mesenchymal, one intermediate case of difficult classification designated as "cellular variant" of congenital mesoblastic nephroma, and one hemangioendothelioma. All patients were alive and free of tumor 3 9/12 to 18 10/12 years after surgery. Of the four infants with congenital mesoblastic nephroma, one was treated by tumor excision alone; nearly 13 years later this patient was free of tumor. A high degree of cellularity and a high nucleus-cytoplasm ratio were features that characterized the tumor diagnosed as "cellular variant" of congenital mesoblastic nephroma. A sarcomatous gross appearance with cavitation necrosis was seen in the two instances of malignant mesenchymal nephroma; one of these metastasized to the lung, whereas in the other, though no metastases developed, all the histologic details of the previous case were reproduced, including distinct foci of necrosis and a high mitosis rate. Mesenchymal renal tumors in young infants constitute a set more heterogeneous than has been previously assumed. They should not be considered uniformly benign. As a group, they span the whole spectrum between benign, morphologically quiescent lesions, clinically and pathologically intermediate or indeterminate ones, and outright malignant tumors with a high risk of distant spread.

Female↗
PubMed1978

Undifferentiated sarcoma of the kidney: a tumor of childhood with histopathologic and clinical characteristics distinct from Wilms' tumor.

The pathological and clinical features of 123 patients with Wilms' tumor diagnosed between 1961 and 1977 were analyzed. A subgroup of nine patients with distinctive histology characterized by the presence of exclusively sarcomatous elements was identified. These patients were indistinguishable clinically from the other patients with Wilms' tumor and were treated as Wilms' tumor. The rate of recurrence in this group of sarcomatous Wilms' tumor was very high (7/9) and long-term disease-free survival correspondingly low )3/9 free of disease from 15 months to nine years) when compared to the patients with classical Wilms' tumor (50% recurrence rate and 71% currently free of disease). In addition, patients with metastases (seven of seven patients with recurrence had skeletal involvement as contrasted to one of 50 patients with metastatic classical Wilms' tumor). We conclude that the "sarcomatous Wilms' tumor" represents a distinct clinicopathological entity identifiable morphologically at diagnosis, best described as renal sarcoma and that in the future optimal treatment of this disease may vary somewhat from the treatment of classical Wilms' tumor.

Bone Neoplasms↗