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Biomedical subjects

J M Klein

Publications and source records attributed to J M Klein.

53 records · Page 3Linked to original sources
PubMed1985

[Unusual cause of digestive hemorrhage in chronic hemodialysis patients: splenic aneurysm with arteriovenous fistula].

A 45 years old woman, hemodialysed since 1981, with an history of Staphylococcal septicemia in may 1983, is admitted in emergency room in may 1984 for massive gastro intestinal bleeding. After oesogastro fibroscopy suspecting duodenal ulcer, because continuous and recurrent bleeding, a laparotomy find only symptoms of portal hypertension (ascites, venous dilatation on abdominal oesophagus and stomach). The ligation of this venous dilatations stop temporarily the gastro intestinal bleeding. But recurrence of this bleeding conduct to a celiac angiography discovering a splenic aneurysm with arterio venous fistula. The surgical treatment of this aneurysm can stop the gastro intestinal bleeding. Histopathologic observation of this aneurysm can suspect an infectious origin.

Arteriovenous Fistula↗
PubMedDate not supplied

Localization of epidermal growth factor receptor in alveolar epithelium during human fetal lung development in vitro.

Epidermal growth factor (EGF) enhances alveolar type II cell differentiation. In human fetal lung explants, EGF stimulates surfactant protein A (SP-A) synthesis. This effect may occur through a direct interaction of the ligand on EGF receptors located within distal pulmonary epithelium during alveolar type II cell differentiation. To determine if EGF receptor is present in alveolar epithelium, immunostaining for EGF receptor and in situ hybridization for EGF receptor mRNA were performed in human fetal lung explants undergoing alveolar type II cell differentiation in vitro. After 4 days in culture, EGF receptor immunostaining was present in alveolar epithelium from human fetal lung explants compared to minimal immunostaining in undifferentiated human fetal lung epithelium prior to culture. In situ hybridization revealed increased EGF receptor mRNA in differentiated type II cells from cultured explants, with minimal EGF receptor mRNA detected in undifferentiated epithelium from tissue prior to culture. Immunogold staining revealed EGF receptors on the cytoplasmic membranes of epithelial cells lining the prealveolar ducts in human fetal lung explants after 2 days in culture. Alveolar type II cell differentiation in vitro was confirmed ultrastructurally by the presence of lamellar bodies and biochemically by an increase in SP-A content. Thus, EGF receptor is found in alveolar epithelium during differentiation, which suggests an important role for EGF during human fetal lung development.

Embryonic and Fetal Development↗
PubMedDate not supplied

[Arboviruses in Iran (author's transl)].

During an entomological survey conducted in april-june 1978 in the province of Khorassan in the eastern part of Iran, ixodid and argasid ticks were collected for arbovirus research. Five serotypes of arboviruses were obtained: Quaranfil, Thogoto, Wad Medani, Wanowrie and Crimean Haemorrhagic Fever-Congo. The isolation of all these arboviruses is reported for the first time in Iran.

Animals↗