Biomedical subjects
J M L White
Publications and source records attributed to J M L White.
Severe generalized argyria secondary to ingestion of colloidal silver protein.
Argyria is a rare cause of cutaneous discolouration caused by silver deposition. We report a case of dramatic and diffuse argyria secondary to ingestion of colloidal silver protein over a 1-year period. Stained electron microscopy with spectral analysis was used to confirm the clinical diagnosis. Silver-protein complexes are deposited in the skin and reduced to inert silver salts by sunlight in a process similar to that harnessed in photography. Our patient had obtained the silver for consumption via mail order. It had been advertised as a cure for a variety of diseases. Colloidal silver protein is commercially available as a 'food supplement', hence circumventing the strict controls placed on medicines.
Haemorrhagic bullae in a case of paroxysmal nocturnal haemoglobinuria.
Paroxysmal nocturnal haemoglobinuria is a clonal stem cell disorder manifesting as haemolysis, bone marrow failure and thrombosis. We report a rare cutaneous manifestation on the trunk of a 40-year-old patient. Skin biopsy revealed the presence of fibrin thrombi in the capillaries. The eruption responded within days after commencing oral corticosteroids.
Case 1. Cervicofacial actinomycosis.
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Granulomatous amoebic encephalitis.
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