Biomedical subjects
Publications and source records attributed to J M Leclere.
Delayed hypersensitivity to heparins and heparinoïd is a problem for prophylaxis of thrombo embolic diseases. The hirudins did not seem to have any cross-reactivity with the two others groups of anticoagulants. We present two clinical cases of delayed type reactions to heparins and heparinoïd and we reviewed the literature about adverse reactions to low molecular weight heparins and the alternative possibilities.
This article describes a biophysical investigation to determine the physiological integrity of isolated cardiac fibers obtained during surgery. Immediate biopsy of myocardium can be analysed dynamically in various physiological conditions using an intelligent dynamometer controlled by an "APPLE II" microcomputer generally in less than fifteen minutes. Multiple tests including pharmacological and electrical properties of fibers can now be done with this cardiac analyser. Primary investigations on heart diseases show the importance of the method for evaluation of heart necrosis.