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Biomedical subjects

J M Mann

Publications and source records attributed to J M Mann.

At least 163 records · Page 9Linked to original sources
PubMed1980

Postexposure trial of a human diploid cell strain rabies vaccine.

A human diploid cell strain vaccine (HDCV) was evaluated in 90 persons treated after exposure to rabies, 21 of whom were bitten by proven rabid animals. Intramuscular doses of HDCV were given on days 0, 3, 7, 14, and 28, and human rabies immune globulin (HRIG) was given on day 0. Antibody to rabies virus was tested for by the rapid fluorescent focus inhibition test; adverse reactions were assessed from physician's forms. All 87 persons tested developed titers of greater than or equal to 0.5 international units (IU)/ml, with a maximum geometric mean titer of 15.0 IU/ml on day 42. One year after vaccination, all 33 persons tested had antibody to rabies virus. After one or more doses of vaccine, mild local or systemic reactions were reported in 19.0% and 21.4% of persons, respectively. No serious reactions occurred. The results show that this HDCV (plus HRIG) was safe and effective in eliciting antibody in postexposure prophylaxis of rabies. When it becomes available, it is recommended over the present treatment regimen.

Adolescent↗
PubMed1980

Anti-rabies treatments in New Mexico: impact of a comprehensive consultation-biologics system.

Fewer than 20% of the 30,000 anti-rabies treatments administered in the United States each year are necessary. New Mexico established a comprehensive consultation-biologics program to assist physicians in making appropriate and systematic rabies treatment decisions. In 1978, 32 individuals received anti-rabies treatments as the result of 144 physician consultation requests. Dog and cat exposures accounted for 70 per cent of consultations and 63 per cent of the treatments. A seasonal peak of both consultations and treatments was observed in the summer and early autumn. The cost of biologics was $212 per treatment. Coordinated use of laboratory diagnostic services and animal control resources obviated the need for treatment in over 60 per cent of the 112 consultations not resulting in treatment. Experience in 1978 suggested that the system was probably responsible for a greater than five-fold reduction in the annual rate of anti-rabies treatments in New Mexico. Efficient physician utilization and high acceptability of the program may be attributed to maximization of private sector input into design and implementation of this public health program.

Adult↗
PubMed1979

Plague pneumonia.

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Adolescent↗
PubMed1979

Endemic human plague in New Mexico: risk factors associated with infection.

A retrospective case-control study was conducted to identify risk factors, other than contact with infected animal tissues, for infection caused by Yersinia pestis in non-Indian residents of areas with endemic sylvatic plague in New Mexico. The study group consisted of 16 persons who had bacteriologically confirmed cases of plague in the period 1975-1976 and 45 controls who were matched by age, sex, and location of residence. Participants were questioned about outdoor activities, environmental conditions in and around the home, procedures of pet care, exposure to animals and insects, and medical history. The availability of harborage and food sources for wild rodents as a result of human activity in the immediate home environment was associated with risk of infection. Failure to take steps to control fleas on dogs and cats also appeared to be a possible risk factor. No other significant differences were found between patients and controls. Plague in New Mexico appears to result primarily from entry of the reservoir host into the habitat of the human rather than from entry of the human into the sylvatic habitat of the reservoir host.

Animals↗
PubMed1978

HLA frequencies, diabetes mellitus and autoimmunity in Turner's patients and their relatives.

In a preliminary study of twenty-three patients with gonadal dysgenesis (Turner's syndrome) and their families, correlation was sought between their serum defined HLA allele frequencies and their known tendencies toward abnormal immune responses and diabetes mellitus, since individuals with the latter disorders have been shown to have an increased frequency of certain HLA types. We were unable to demonstrate an association between these major serum-defined histocompatibility antigens, immune homeostasis disturbances and sex chromosome aneuploidy in this group. It is felt, however, that testing involving the patterns of HLA-D and "HLA-D related" antigen frequencies should be obtained to further evaluate the possibility of such an association.

Alleles↗
PubMed1972

Factors influencing the microbiological assay of tobramycin.

Tobramycin belongs to the aminoglycoside class of antibiotics. Assay procedures were investigated to determine the most suitable methods for the assay of tobramycin in blood, urine, and pharmaceutical preparations. The agar-plate assay was the method of choice for determinations in urine and serum. The turbidimetric assay was selected for the assay of pharmaceutical preparations. An extraction technique is described that minimizes problems encountered in the estimation of tobramycin in urine. Sample diluents, pH, and molarity were important and were variable depending on assay methods. Evidence is presented to show binding of tobramycin to alpha-cellulose susceptibility discs. Iron and sodium ions demonstrated potential inhibition of tobramycin in all assay methods tested.

Aminoglycosides↗
PubMed1968

Hemagglutinating property of Haemophilus aegyptius.

Extracts possessing the capacity to hemagglutinate normal human erythrocytes were recovered from Haemophilus aegyptius by treatment with either diethylene glycol or acetone. Antisera prepared against these extracts or the unextracted bacterial cell inhibited hemagglutination by homologous and heterologous antigens. Microgel diffusions indicated the presence of identical components in each extract as expressed by lines of identity between antisera to each fraction. The hemagglutinin was identified as a lipopolysaccharide, 42% lipid and 57% carbohydrate. The determination of 6% phosphorus in the lipid fraction identified it as containing phospholipid.

Antigens↗