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Biomedical subjects

J M Mascaro

Publications and source records attributed to J M Mascaro.

At least 91 records · Page 5Linked to original sources

[Cellular immunity in polymorphous light eruption].

Lymphocytic-cell subsets (T total, T helper, T suppressor-cells) have been studied with Monoclonal Antibodies (OKT-3, OKT-4, OKT-8) in 21 patients with Polymorphous light Eruption in inactive phase and have been compared with 13 controls. The results shvon normal cell figures (T total, helper and suppressor). However, when observing the ratio between T helper cells and T suppressor cells, a slight decrease in this ratio is appreciated, which would correspond to a relative increase of suppressor cells. These results are similar to those obtained for the inactive S. L. E. (9).

Humans↗

[Cutaneous myelofibrosis].

A case of myelofibrosis with papulonodular cutaneous lesions in a 49 year old man is reported. The histopathological studies showed the presence of the three hematopoietic lines in the skin lesions, which is a uncommon feature.

Hematopoietic Stem Cells↗

[Footwear contact dermatitis. 11-years' experience].

A clinical review of footwear contact dermatitis is made. The battery of contact allergens for the patch test is proposed. A review of the cases studied in the Department during the last 11 years is presented. In approximately 25 per cent of typically clinical cases it is not possible to establish the exact cause of the contact allergy.

Allergens↗

[Polypoid pseudosarcoma of the tongue].

Polypoid pseudosarcoma (PP) is a rare type of squamous-cell carcinoma of mouth, fauces and larynx with sarcoma-like reaction. Clinically PP is characterized by large pedunculated or sessile masses of rapid growing. This tumour recurs easily but rarely provokes metastasis. A case of polypoid pseudosarcoma of the tongue is reported. Differential diagnosis with spindle-cell carcinoma can be made following the criteria: a) the frequency and the sarcomatous appearance of the metastasis in the spindle-cell carcinoma, while PP rarely provokes metastasis which have a squamous-cell pattern; b) the gradual transition within the epithelial and the sarcomatous aspects in the spindle-cell carcinoma, not present in PP; and c) the presence of tonofilaments and desmosomes in the sarcomatous cells of the spindle-cell carcinoma, which lack in the sarcoma-like masses of PP.

Aged↗

Specific cutaneous manifestations of Waldenström's macroglobulinaemia. A report of two cases.

Patients affected by Waldenström's macroglobulinaemia may rarely present specific cutaneous manifestations. The violaceous plaques or tumours infiltrated by lymphoplasmocytoid cells, and the pink, translucent, shiny papules composed of deposits of hyaline monoclonal IgM possess definite clinico-pathological characteristics that may permit the diagnosis before any other data were available. The immunopathological and ultrastructural features of these lesions are described.

Aged↗

Photocontact dermatitis to cobalt salts.

4 patients with chronic photocontact dermatitis were sensitive to cobalt salts. They presented as cases of contact dermatitis from cement or pig fodder with persistent lesions on exposed areas. Only 2 of them had standard patch test positive reactions to chromate and cobalt, but all showed positive photo-patch tests to cobalt. Photo-oxidation tests proved that cobalt salts are photosensitizing. Exposure to cobalt salts was responsible for the patients' chronic actinic dermatitis.

Adult↗

Hepatoerythropoietic porphyria: a new uroporphyrinogen decarboxylase defect or homozygous porphyria cutanea tarda?

Uroporphyrinogen decarboxylase levels were measured in haemolysed whole blood or fibroblasts from 3 unrelated patients with hepatoerythropoietic porphyria (HEP) and in 4 unrelated patients with familial porphyria cutanea tarda, a condition in which the enzyme is defective. In HEP patients enzyme activities were 7% of normal in erythrocytes and 8% of normal in cultured skin fibroblasts. All the features of HEP, including the characteristic accumulation of protoporphyrin in erythrocytes, are secondary to this enzyme defect. The father of 1 HEP patient was heterozygous for the same enzyme defect. He also had uroporphyrinuria and was therefore indistinguishable from patients with subclinical familial porphyria cutanea tarda. It is suggested that patients with HEP are homozygous for the gene that causes porphyria cutanea tarda.

Child↗

[Dermatitis caused by "Milwaukees"].

The authors report five cases of a non specific clinical eruption in patients who wore "milwaukee". The lesions appeared 20 to 50 days after they begun to use the "milwaukee", in the zones where the plastic contacted their skin. Negative patch test, and microscopical studies of lesions and patch tests, suggested an irritative non allergic dermatitis.

Adolescent↗