Biomedical subjects

J M McClellan

Publications and source records attributed to J M McClellan.

4 recordsLinked to original sources

PubMed1992

Predicting outcome in child and adolescent (early onset) schizophrenia and bipolar disorder.

Fifty-nine patients with DSM-III-R early onset (mean, 13.9 years) psychoses of schizophrenia (N = 30) or bipolar disorder (N = 23) were seen at follow-up (mean interval, 5 years; mean age, 19 years). About 50% of the variance in outcome was predictable using stepwise multiple correlation, which has the advantage of eliminating redundancy among variables and giving a quantitative estimate for each predictor. Abnormal premorbid adjustment/personality and degree of recovery after initial hospitalization were the substantial predictors in schizophrenia, whereas in bipolar disorder, they were premorbid adjustment and IQ. Other items such as diagnosis (bipolar or schizophrenia), symptoms, and gender predicted at too low a level to be useful clinically. Though psychosis is necessary for diagnosis, premorbid personality abnormality may be an indicator of an early onset, developmental type schizophrenia with poor prognosis.

Adolescent↗

PubMed1992

Schizophrenia.

Schizophrenia occurring in childhood and adolescence has similar diagnostic, prognostic, and treatment ramifications as those noted with adult-onset schizophrenia. In assessing a child or adolescent suspected of having schizophrenia, care must be given to document DSM-III-R diagnostic criteria within the developmental framework of the patient's functioning, while thoroughly evaluating for other potentially confounding disorders or conditions. Antipsychotic therapy is the only specific treatment for schizophrenia, and should be a fundamental component with a multimodal treatment program that also addresses the psychological, social, and educational needs of the patient and his or her family. Strategies for medication management vary depending on several factors, including the stage of the disorder, noted or potential side effects, and the response of the patient to treatment, and need to be coordinated for the long term by a child or adolescent psychiatrist familiar with the diagnosis and treatment of schizophrenia in this age group.

Adolescent↗

PubMed1991

Childhood and adolescent schizophrenic, bipolar, and schizoaffective disorders: a clinical and outcome study.

Fifty-nine child and adolescent psychotic patients (mean onset age 13.9, range 7-17, 83% 13 + years) had history and outcome studied using diagnoses confirmed at follow-up after 1 to 16 years (mean, 5 years). There were no differences in sex ratio, socioeconomic status, age of onset, and symptoms, but bipolar patients (N = 23) were often misdiagnosed as schizophrenic, had a better outcome, and a 50% homotypic family history. Schizophrenic subjects (N = 30) were more abnormal premorbidly, and only 17% were well at follow-up. Schizoaffective disorder was unreliable, infrequent, and more severe. Premorbid adjustment and IQ were the best predictors of outcome. Differences from the adult disorders were only quantitative. Careful follow-up of psychotic patients is needed to detect diagnostic errors.

Adolescent↗

PubMed1990

Attention deficit disorder in children at risk for anxiety and depression.

The comorbidity between attention deficit disorder (ADD) and anxiety and/or depressive disorders was examined in the children of parents with panic disorder, major depressive disorder, or with no diagnosis. A child received a diagnosis by a self-report, parent report, and by consensus, using a best estimate procedure. The prevalence rates of ADD were significantly greater in offspring of parents with depressive and panic disorder by the parents' report and in children of depressed parents by consensus. A significant relationship between ADD and anxiety and/or depression was found for parent, child, and consensus diagnoses. Higher rates of ADD were reported by children (1% versus 13%), parents (8% versus 31%), and in the consensus diagnoses (13% versus 29%) when anxiety and/or depression was present. These results suggest that in children referred for evaluation of ADD, the possibility of a primary anxiety or depressive disorder should be considered.

Adolescent↗