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Biomedical subjects

J M McLean

Publications and source records attributed to J M McLean.

13 recordsLinked to original sources
PubMed1991

Changes in the rat lymphoid tissues after Leydig cell destruction by ethane-1,2-dimethanesulphonate.

Since ethane-1,2-dimethanesulphonate (EDS) causes Leydig cell destruction which may elicit an immune response the lymphoid tissues of sexually mature male rats were examined after an intraperitoneal injection of EDS. The changes observed in the testicular regional lymph nodes confirm an immune response while those observed in the thymus may indicate involvement in the immunological response or be a toxic reaction to EDS.

Animals↗
PubMed1988

Cellular proliferation in the lymphoid tissues of an inbred (RT1a) rat strain during the oestrous cycle.

Changes in body weight, uterine weight and tissue weight, cell content and cellular proliferation of the thymus and uterine regional and popliteal lymph nodes were examined at daily intervals during the oestrous cycle of the DA (RT1a) inbred rat strain. Thirty-nine sexually mature virgin animals, aged between 13 and 15 weeks were used in this investigation. During dioestrus body weight and uterine weight fell significantly, while intrathymic and intranodal cellular proliferation increased significantly. These findings are discussed in relation to ovarian hormone secretion and it is suggested that increased thymocyte and lymphocyte proliferation occurs in response to rising oestrogen levels. This proliferative response prepares the female for the immunological challenge with allogeneic spermatozoa should mating occur during the subsequent oestrous phase.

Animals↗
PubMed1987

A dioestrous increase in thymocyte proliferation during the oestrous cycle.

Coitus, which precedes internal fertilisation, is a unique physiological event which allows motile allogeneic spermatozoa to enter the female host and invade her tissues. The cyclic cellular proliferation observed in the thymus of the female rat may be an important preparation of her immune system for this event.

Animals↗
PubMed1986

MRI of cerebral vein thrombosis in infancy: a case report.

We diagnosed primary idiopathic cerebral vein thrombosis in an infant by MRI. The relative noninvasiveness of the scan, ease of imaging in multiple planes, and good image resolution suggest that the scan may be useful in this disorder.

Humans↗
PubMed1985

Vertebral artery rupture associated with closed head injury. Report of two cases.

The authors report two patients with closed head injury who suffered laceration with rupture of the third portion of the vertebral artery. One patient died suddenly, with angiographic evidence of bilateral vertebral artery rupture. The mechanism of injury to the C1-2 segment of the vertebral artery relating to head and neck injury is discussed.

Adult↗
PubMed1985

The cell content and proliferative response of the rat thymus during first syngeneic and allogeneic pregnancy, and the effects of strain difference.

Two hundred female rats, 91-101 days of age, were used in this investigation which provided data on cell content and proliferative response of the thymus. The observations began in oestrous phase virgin females from two highly inbred strains AO(RT1u/AgB2) and DA(RT1a/AgB4), continued at five day intervals throughout syngeneic and allogeneic pregnancy in both strains and were completed in the immediate post-partum period. This experimental protocol permitted sequential observations throughout gestation and allowed syngeneic: allogeneic and interstrain comparisons to be made. The syngeneic: allogeneic comparisons demonstrated significant differences in the thymic proliferative responses while the AO:DA comparisons demonstrated significant differences in the thymic cell contents.

Animals↗
PubMed1979

Lymphoid response to pregnancy and pseudopregnancy in the rat.

Differences in weight, while cell density and differential white cell count of the thymus, spleen, iliac and popliteal lymph nodes of virgin, 10 days outbred pregnant, 10 days inbred pregnant, 10 days pseudopregnant, and 40 days outbred post-coitum rat were examined. Compared with virgin animals, significant weight gain occurred only in the thymus, spleen and iliac lymph nodes of the outbred group. Significant weight loss from the thymus and iliac nodes, and significant reductions in white cell density of the spleen and popliteal nodes occurred in delivered animals when compared with the virgin group. During pseudopregnancy significant weight loss occurred from the thymus, spleen and popliteal lymph nodes compared with the inbred group, and from the iliac lymph nodes compared with the virgin group. No significant differences were observed between the proportions of proliferating cells in the lymphocyte populations of the thymus, spleen, iliac and popliteal lymph nodes of the virgin group. In the outbred group the proliferating populations of all four tissues rose significantly above virgin levels, while in the inbred group only the iliac lymph nodes showed any significant rise above the virgin value. These findings are discussed in relation to the maternal immunological response to pregnancy.

Animals↗
PubMed1977

Selective abortion.

Explore the source record for details and available documents.

Abortion, Induced↗
PubMed1975

The response of iliac lymph nodes to the fetal allograft.

It is well known that large pyroninophilic cell proliferation in regional lymphoid tissue preceds and accompanies cell-mediated immunological reactions. In the present study of lymph node responses in the pregnant rat it was found that there were no significant differences between large pyronionphilic cell counts from iliac nodes (which drain the uterus) and popliteal lymph nodes, in either virgin or delivered rats. The iliac large pyronionphilic cell count, however, rose significantly in early pregnancy, fell in late pregnancy and returned to virigin levels after delivery, whereas the popliteal large pyronionphilic cell count showed no significant change during pregnancy. It is also well established that plasma cell proliferation in regional lymphoid tissue precedes and accompanies antibody synthesis. In the present studies the plasma cell count in iliac nodes rose significantly and progressively during pregnancy, while in popliteal nodes it rose significantly only in late pregnancy. There was no significant difference between the plasma cell counts of iliac and popliteal nodes in virgin animals. In delivered animals the iliac plasma cell count was significantly greater than the popliteal count, and both were significantly greater than the corresponding virgin counts. It is concluded that the mother possesses the capacity for rejecting the conceptus, but there is some mechanism which blocks rejection.

Animals↗