Canine pemphigus foliaceus associated with leishmaniasis.
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Animals↗
Biomedical subjects
J M Molleda
Publications and source records attributed to J M Molleda.
Local secretory IgA in dogs with low systemic IgA levels.
Low plasma IgA concentrations are commonly found in clinically normal dogs. In order to ascertain the relative importance of local and systemic IgA concentrations as factors determining the absence of clinical signs, IgA concentrations in plasma and tears were assayed in clinically normal dogs with a deficiency of IgA (10.33 +/- 0.63 mg/dl). The IgA levels in tears (25.28 +/- 1.91 mg/dl) did not differ significantly from those of control dogs or from previously published data for dogs. Thus, low systemic levels did not imply a significant reduction in local IgA levels. The absence of clinical signs in dogs with low plasma IgA concentrations may therefore be explained by the presence of normal secretory levels and an effective immune response against local pathogens.
Age Factors↗
Effect of age on serum concentrations of the third component of complement in dogs.
Single radial immunodiffusion was used to determine the concentration of the third component of complement (C3) in canine sera from 48 normal dogs in the following age groups: < 12 months, 12 to 24 months, and > 24 months. Mean serum C3 concentrations, expressed as the percentage of pooled reference sera from 20 dogs, showed a significant (P < 0.017) correlation with age in dogs less than 12 months old, while the character of this correlation was negative for dogs more than 24 months old (P < 0.056). Two-way analysis of variance, for age and sex, revealed significant differences between C3 values from this two groups that were not present when compared with dogs aged between 12 and 24 months old. Sex had no effect on serum C3 concentrations.
Aging↗
Immunoglobulins in stimulated tears of dogs.
Immunoelectrophoresis and single radial immunodiffusion were used to identify and measure tear immunoglobulin concentrations in 50 healthy dogs. Immunoglobulin A and IgG were detected in all samples analyzed, whereas IgM was not detected in any sample. Mean IgA concentration was 25.28 +/- 1.9 mg/dl, adult dogs (> 18 months) having significantly higher mean value. The IgA concentration related to age had significant (P < 0.006) positive correlation; mean IgG concentration was 23.10 +/- 1.72 mg/dl. Linear correlation analysis revealed significant (P < 0.0007) correlation coefficient between tear total protein and IgA concentrations. The IgA and IgG concentrations also were significantly (P < 0.0001) correlated when expressed as milligrams per 100 mg of protein. Relation with sex was not established for either immunoglobulin.
Aging↗
Evaluation of total protein content in tears of dogs by polyacrylamide gel disk electrophoresis.
Concentration of total proteins was measured and sodium dodecyl sulfate-polyacrylamide gel disk electrophoresis was performed on tear and plasma samples obtained from 26 healthy dogs, and the results were compared. Mean +/- SEM concentration of total proteins in tears was 0.63 +/- 0.04 g/dl, and significant effects of age or gender were not found. The protein composition of tears in dogs was complex, and bands from light and heavy chains of immunoglobulins were identified by electrophoresis.
Age Factors↗
Microphakia associated with lens luxation in the cat.
Congenital defects of the lens are rare in the cat. In this report, two unrelated Siamese kittens, a four-month-old male and a six-month-old female, with microphakia are presented. Abnormally small lenses were associated with elongation and rupture of the ciliary processes, leading to lens subluxations and subsequent anterior luxations. To the authors' knowledge, this condition has been reported only once previously.
Animals↗