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Biomedical subjects

J M Mumford

Publications and source records attributed to J M Mumford.

At least 19 recordsLinked to original sources
PubMed2001

Trimethoprim/sulfamethoxazole-induced toxic epidermal necrolysis.

OBJECTIVE: To report a case of toxic epidermal necrolysis (TEN) associated with trimethoprim/sulfamethoxazole (TMP/SMX). CASE SUMMARY: A 34-year-old Asian woman developed a severe, desquamating mucocutaneous reaction (TEN) after six days of taking TMP/SMX to treat a presumed urinary tract infection (UTI). DISCUSSION: TMP/SMX is often recommended as first-line therapy for UTIs, sinusitis, bronchitis, and as prophylaxis and treatment for Pneumocystis carinii pneumonia. TEN is a rare, but severe condition associated with sulfonamide use. This article describes a typical case and offers an opportunity for review of this potentially serious reaction. CONCLUSIONS: Sulfonamides are often implicated in the majority of drug-induced cases of TEN. This case report illustrates the typical presentation of sulfonamide-induced TEN with a prodrome, characteristic rash, mucous membrane lesions, and systemic involvement. Practitioners should be aware of this rare adverse effect and closely observe patients for cutaneous manifestations or complaints. Any suspected drug should be discontinued if clinical evaluation leads to the suspicion of Stevens-Johnson syndrome or TEN.

Adult↗
PubMed1980

Petrous angle and trigeminal neuralgia.

The angle of the petrous portion of the temporal bone was measured at the site where it is crossed by the trigeminal nerve. Measurement was facilitated by using the impression techniques of dentistry to produce a plaster model of the bone, and the model was then sawn across to show the angle clearly. Considerable variation was found. Certain bone irregularities were observed and these could also conceivably be factors in the causation of trigeminal neuralgia. An attempt to reveal the angle of the petrous bone by radiology was successful in some cases but not in others. Further investigation along these lines might be of value in patients suffering from idiopathic trigeminal neuralgia.

Humans↗
PubMed1978

Role of the dentist in trigeminal neuralgia.

It is well known that people with idiopathic trigeminal neuralgia sometimes have teeth unnecessarily extracted. It is less well known that pain which seems to be due to idiopathic trigeminal neuralgia is occasionally due to dental causes. For this reason it is suggested that such cases should be given very careful dental and oral examination before the commencement of drug therapy or surgery. Such an examination must be meticulous and may be tedious as well as time consuming. It should therefore be done by a dentist who is specially interested in pain and who is preferably associated with a centre for pain relief. A few cases may then have their pain relieved by such procedures as fillings, extractions or occlusal adjustment. In all cases the neurologist or neurosurgeon will face his responsibility more secure in the knowledge that all possible peripheral causes have been eliminated. Moreover, patients with idiopathic trigeminal neuralgia may have difficulty maintaining a satisfactory standard of oral hygiene, both before and after treatment. They should therefore have careful attention paid to this as soon as possible.

Adult↗
PubMed1976

Stimulus-evoked pain in teeth.

When pain occurs in teeth as a result of external stimulation it is more likely to be due to physical factors affecting the enamel and dentine than to pulp disease. The mechanisms are described, clinical conditions are mentioned and a speculative attempt is made to correlate them by introducing the idea of streaming potentials in the dentine and pulp. The pain perception threshold is considered in relation to different teeth, age, sex, lateral dominance, personality, and the area of electrode contact. The latter has proved interesting, for manipulation of it has led to possibly important findings on the nature of convergence in the trigeminal system, two-point discrimination, referred pain and somatopic representation of dental pulps in the medulla oblongata.

Age Factors↗
PubMed1976

Electronic tooth stimulator for pain research.

It is not possible to measure pain but it is possible to measure the stimulus that causes it. Electrical stimuli are probably the most suitable since they can be readily produced and accurately measured. Applying stimuli to the teeth of human subjects is convenient and does not cause damage. This paper describes a tooth stimulator which is considered to be an advance on other available equipment, being easier to use and more accurate, as well as reassuring for the human patient or experimental subject.

Electric Stimulation↗