PubMed HealthSearch

Biomedical subjects

J M Nauta

Publications and source records attributed to J M Nauta.

9 recordsLinked to original sources

Comparison of epithelial dysplasia--the 4NQO rat palate model and human oral mucosa.

Epithelial dysplasia in the rat palatal mucosa was induced by application three times a week of the carcinogen 4-nitroquinoline 1-oxide (4NQO). With the Epithelial Atypia Index (EAI), the successive stages of 4NQO-induced epithelial dysplasia were compared with specimens of human oral epithelial dysplasia. It appeared that there was a close similarity between the histologic features of 4NQO-induced dysplasia in the rat palatal mucosa and human oral epithelial dysplasia. Thus, the 4NQO rat palate model seems to be appropriate to study and assess new treatment modalities of premalignant epithelial lesions of the oral mucosa in man.

4-Nitroquinoline-1-oxide

Peripheral ameloblastoma. A case report and review of the literature.

Peripheral ameloblastoma is a benign odontogenic tumor with the same histological characteristics as the centrally located ameloblastoma, but appearing in the gingiva and mucosa of the tooth-bearing area of the jaws. A review is presented of 53 cases: 45 being reported as peripheral ameloblastoma and 8 as basal cell carcinoma of the gingiva, including the case presented. Based on the review it is recommended to treat this lesion by local excision including a small margin of healthy tissue. Local recurrence is unlikely, unless incomplete removal is performed.

Adult

[Hypertrophy of the inferior labial frenum].

Hypertrophy of the inferior labial frenum, which is present in approximately 8% of the population, can give rise to prosthodontic or periodontal problems. In contrast to hypertrophy of the superior labial frenum, there is no relation to orthodontic problems. The indications for extirpation of a hypertrophic inferior labial frenum are discussed.

Humans