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Biomedical subjects

J M Oliveira

Publications and source records attributed to J M Oliveira.

6 recordsLinked to original sources
PubMed1992

Coronary artery bypass surgery with intermittent aortic cross-clamping.

Despite the generally accepted use of cardioplegia for myocardial protection during cardiac revascularization and other operations, non-cardioplegic methods have been used by many surgeons throughout the world. We have prospectively studied 229 patients consecutively subjected to isolated coronary artery bypass surgery from March 1990 to February 1991 by a single surgeon who used intermittent aortic cross-clamping for construction of the distal anastomoses. The mean age of the patients was 58.9 +/- 8.9 years. One hundred and nine patients (47.6%) with unstable angina were subjected to urgent or emergent surgery and 129 (56.3%) had a previous myocardial infarction. The mean number of grafts per patient was 3.0. The ischaemic time per graft was 6.5 +/- 1.4 min. At least one internal mammary artery was used in 98% of the cases (1.4 internal mammary artery grafts/patient). Hospital mortality was 0.9% (two patients, in neither case related to the procedure). Only nine patients (3.9%) required inotropes and none needed intra-aortic counterpulsation. The analysis of serum enzymes specific of myocardial lesion showed a CPK-MB/CPK ratio of 10.5 +/- 10.2 after surgery, 6.4 +/- 6.6% at 24 h after surgery, and 6.9 +/- 2.6% by the 5th day. Only four patients (1.7%) had ECG criteria of myocardial infarction. These results were compared retrospectively with those of the 40 immediately preceding patients (December 1989 to February 1990), in whom crystalloid cardioplegia had been used. There were no differences between the two groups with regard to age, prevalence of unstable angina and of previous myocardial infarction, and technique used.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

Ventricular septal defects and arteriovenous fistulas, with and without valvular lesions, resulting from penetrating injury of the heart and aorta.

Thirty-one patients with post-traumatic intracardiac shunts or arteriovenous fistulas were treated surgically in the past 8 years. All patients had had penetrating injuries of the heart, ascending aorta, or aortic arch 1 week to 4 years earlier, but only three had an early emergency operation. Eleven patients (35%) had ventricular septal defects and seven (23%) had other types of intracardiac fistulas. The remaining 13 patients had fistulas between the aorta and the main pulmonary artery or innominate vein. Nine patients (29%) had injury of one of the four cardiac valves. All patients but six with aorta-innominate vein fistulas were operated on with the assistance of cardiopulmonary bypass. All affected valves were successfully repaired. There were no operative deaths but two patients (6%) died late. The remaining 29 patients were alive and well when last seen, with no signs of residual shunt and with good valve function. The high prevalence of late complications necessitates routine investigation of patients with penetrating injuries of the heart and the aorta. Surgical correction carries a low mortality and morbidity and is advised in all patients with symptoms.

Adult↗
PubMed1988

Medtronic Hall valve replacement in a third-world population group. A review of the performance of 1000 prostheses.

Between May 1980 and December 1984, 1000 Medtronic Hall prostheses (538 mitral and 462 aortic) were implanted in 852 patients (mean age 30 +/- 15 years) of a third-world type of population group. The most common valve lesions were aortic and mitral regurgitation, and 32% of the patients were in New York Heart Association class IV or greater. Double valve (aortic and mitral) operations were performed in 209 patients. The 782 operative survivors were followed up for 2 to 6.5 years (mean 3.5 years) for a cumulative 2676 patient-years. Valve performance was analyzed in each position separately for valve-related complications. Results for the whole group for the following events are expressed in both linearized (percent/patient-year) and actuarial (percent +/- standard error of the mean freedom at 5 years) terms, respectively: valve-related mortality, 2.9 and 92 +/- 2; reoperation, 1.9 and 90 +/- 2; systemic thromboembolism, 3.3 and 85 +/- 2; thrombotic obstruction, 1.2 and 95 +/- 1; prosthetic valve endocarditis, 0.7 and 97 +/- 1; anticoagulant-related hemorrhage, 0.7 and 98 +/- 1; and periprosthetic leak, 0.7 and 97 +/- 1. Corresponding composite figures for valve failure were 4.3 and 85 +/- 2, and for all valve-related morbidity and mortality were 6.7 and 75 +/- 3. Thrombotic obstruction (fatal in 71% of the cases), anticoagulant-related hemorrhage (61% fatal), and prosthetic endocarditis (44% fatal) were the most lethal complications. Although the differences did not reach statistical significance, aortic prostheses appeared to have a higher incidence of complications than the mitral prostheses. When analyzed against the background of an essentially noncompliant population group, the Medtronic Hall prosthesis proved to be reliable and remarkably free from structural failure. The high incidence of thromboembolism and thrombotic obstruction still mandates anticoagulation.

Adult↗