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J M Rendel

Publications and source records attributed to J M Rendel.

7 recordsLinked to original sources
PubMed1976

Is there a gene regulating the scute locus on the third chromosome of D. melanogaster?

A section of the third chromosome of D. melanogaster some 25 to 40 centimorgans long including sr was transferred from a wild-type stock selected by Latter for high scutellar bristle number into a scute stock with a large number of scutellar bristles. This segment is shown to have a large effect on the bristle numbers of wild-type flies, to reduce the strength of canalization of the scute phenotype at 4 bristles, to have little, if any, effect on bristle numbers of scute flies with less that 4 bristles but to increase the number of flies with 5 and 6 scutellar bristles in scute stocks that normally have a large number of flies with 4 bristles. It is suggested that this segment in unselected chromosomes contains a gene that regulates bristle number by repressing the scute locus and that Latter has selected a mutant of the regulator which fails to repress the aciton of the scute locus.

Animals↗
PubMed1969

A model relating gene replicas and gene repression to phenotypic expression and variability.

It is suggested that the development of a dominant character in higher organisms starts with the activation of a major gene. This gene replicates; the number of replicas is controlled by a second gene or set of genes, which also ensure that the most suitable allele, if more than one is present, makes the replicas. The major gene replicas then make messenger RNA and are reinforced in this by minor genes. The joint product of major gene replicas and minor genes activates a fourth gene or set of genes which produce a repressor that damps down the activity of the major gene replicas. The evidence for this scheme, which comes from studies of selection experiments in populations, is summarized and the evidence from studies of DNA and RNA metabolism is referred to in this paper.

DNA Replication↗