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Biomedical subjects

J M Rivera Pomar

Publications and source records attributed to J M Rivera Pomar.

16 recordsLinked to original sources

Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the lizard and frog muscles, another fiber type does exists that could not be demonstrated in higher vertebrates. When more than one histochemical techniques are used for the identification of each tetrapod fiber types, the lack of correlation between them becomes obvious. Thus, different animals groups, each showing a characteristic muscle metabolic pattern, could be distinguished.

Animals↗

Tubular aggregates in skeletal muscle of chronic alcoholic patients.

The presence of tubular aggregates (TA) in type II muscle fibers in two of 20 alcoholic patients with chronic liver disease, and with no apparent neuromuscular disorder, is reported. The localization, histochemical reactions, and ultrastructural features of the TA are similar to those previously described in other conditions. In one of the two cases TA were demonstrated by E/M observations only and not by histochemistry. No correlations were found between the biochemical changes and the presence of tubular aggregates. We believe that TA are long-standing structures since the muscle biopsies were performed 12 and 13 days after the ingestion of alcohol had been discontinued. They may represent a non-specific response of the sarcoplasmic reticulum to compensate for the deficient calcium uptake reported in alcoholic patients.

Adult↗

[Menkes disease: anatomoclinical study].

This paper presents the anatomoclinical study accomplished on a patient with Menkes Syndrome, which shows typical clinical, radiological and anatomopathological changes, as well as very low levels of copper. The hair changes observed with scanning electronmicroscopy are shown. Through the study of the literature the actual controversy on this disease is analyzed.

Bone and Bones↗

Kuru plaques in the brain of two cases with Creutzfeldt-Jakob disease. A common origin for the two diseases?

We present two patients aged 66 and 69, with a rapidly progressive disease (10 and 15 months' duration) in which the presenting symptom was instability of gait. Later dementia was also a prominent feature. One case had myoclonus. Repeated EEGs showed symmetrical slowing in one case and periodic generalised bursts of triphasic waves at 1 cps superimposed upon a slow (3-4 cps) background activity in the other. The pathological findings consisted of classical Creutzfeld-Jakob disease (CJD), Kuru plaques (KP) were disseminated in the brain, but were more numerous in the cerebellum, putamen and thalamus. Neurons with large vacuoles in the cytoplasm were numerous in the putamen, thalamus and anterior horns. Stress is laid upon the common findings in both CJD and Kuru (K) (clinical features, pathological data, lack of antibody response, transmissibility, change in pattern on transmission). The possibility of a common origin of the two diseases is discussed.

Aged↗

[Ultrastructure of Darier's disease].

Biopsies from four patients with Darier's disease were studied by electron microscopy. The desmosome-tonofilament complex does not seem to be primarily involved in the acantholytic process responsible for the epidermal cells separation with formation of suprabasal lacunae. Grains and corps ronds are consistent histopathological findings in Darier's disease: the ultrastructure of these cells is described.

Darier Disease↗

[Muscle changes in chronic obstructive arteriopathy: a morphological, histochemical and morphometric study].

Muscular alteration due to chronic obstructive arteriopathy in lower extremities was studied in 50 patients. An arteriosclerotic pure clinical picture was found in a 50% of them, while the other were associated to diabetes. Histopathological features present in both groups were quite similar and no substantial differences between diabetic and non diabetic patients were found. In patients with an acute clinical course, myopathic changes predominate in tibialis anterior muscle. However, neuropathic alterations were more frequently found in patients with a chronic clinical course. Although histological changes characteristic of chronic obstructive arteriopathy do not exist, this disease can be defined by a characteristic association of muscle lesions that will constitute the "chronic ischaemic myopathy" histological picture. Because of this, muscle biopsy examination in such patients will deliver important information to orient therapeutic attitudes and prognostic predictions.

Arterial Occlusive Diseases↗