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Biomedical subjects

J M Rochford

Publications and source records attributed to J M Rochford.

5 recordsLinked to original sources
PubMed1985

Ceruletide for schizophrenia: a double-blind study.

Ceruletide, an analog of cholecystokinin (CCK), has been reported to have neuroleptic-like activity in mice, and, in three open studies, to benefit schizophrenic patients. This study evaluated ceruletide in schizophrenia using a double-blind design. Subjects were 17 chronic schizophrenics with residual symptoms following stabilization with neuroleptics. Patients randomly received two injections, 1 week apart, of either ceruletide (0.6 microgram/kg im) or placebo, while continuing neuroleptics; this regimen was found helpful in earlier studies. Evaluation included ratings of 29 variables related to prognosis in schizophrenia (e.g., age, number of previous hospitalizations), regular BPRSs and SCL-90s, and psychiatrist, patient, and relative ratings of global improvement. Results showed few significant differences between ceruletide and placebo, with exceptions as likely to favor placebo as ceruletide. Among the patients on ceruletide, no predictors of benefit were found. Possible reasons for the negative results are discussed.

Antipsychotic Agents↗
PubMed1981

The quantitative hemispheric EEG in adolescent psychiatric patients with depressive or paranoid symptomatology.

The quantitated EEG of a clinically heterogeneous small group of 13 adolescent psychiatric patients with paranoid or depressive symptoms was compared to that of 26 normal adolescents. While in most controls the variances of the distributions of EEG amplitudes were similar between right and left hemispheres, it was found that higher variances in the right than in the left were significantly more prevalent in patients with depressive symptomatology while it was the reverse in patients with paranoid symptomatology in whom the variances were significantly higher in the left than in the right hemisphere.

Adolescent↗