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Biomedical subjects

J M Roux

Publications and source records attributed to J M Roux.

At least 19 recordsLinked to original sources
PubMed1994

Limy bile. A surgical experience in 16 patients.

OBJECTIVES: This study is a retrospective analysis of clinical symptoms and operative findings in 16 patients with limy bile (mean age: 47.3 years, M/F ratio: 1/7) operated on over a 25-year period. METHODS: The patients were separated into two groups: patients with limy bile limited to the gallbladder and those with limy bile extending to the common bile duct. RESULTS: In the group of patients with limy bile in the gallbladder (n = 11), previous attacks of biliary pain were present in 9 and the gallbladder was entirely inactive in 9; an elective cholecystectomy was performed; an impacted stone was found in the neck of the gallbladder (n = 5) or in the cystic duct (n = 6), and the intraoperative cholangiogram was normal. The material deposited in the gallbladder was characteristically creamy or dense, white or yellow-brown, and consisted of calcium carbonate. The patients with limy bile extending to the common duct (n = 5) were admitted with acute pain and jaundice, and operated on a few days later. In the common bile duct, limy bile was associated with small stones (n = 4). CONCLUSION: Abdominal radiographs are sufficient to identify limy bile. The presence of this condition in the gallbladder is always associated with biliary lithiasis and the obstruction of the cystic duct. The presence of limy bile in the common bile duct is due to the migration of impacted stone and calcareous material deposited in from the gallbladder. Surgical treatment is only necessary in patients with specific biliary symptoms.

Adolescent↗
PubMed1989

Insulin release from isolated islets of Langerhans after segmental-pancreas autotransplantation in dogs.

Pancreas transplantation is warranted essentially by the quality of glucose regulation. Although the fasting blood glucose is invariably normal, this may not be the case during glucose load tests. The purpose of this study was to examine dysregulation within the isolated islet originating from a segmental-pancreas autograft in the dog. Results show an increased basal insulin secretion by the graft islets in static incubation compared with that of islets originating from the head of the pancreas and left in situ. This abnormal secretion may be accounted for by various factors intervening within the graft or the isolated islet, thus suggesting a possible improvement in the surgical model.

Animals↗
PubMed1987

Biliary lithiasis in the over seventy-five age group: a new therapeutic strategy.

Sixty-four gallstone patients aged 75 or more (mean age 83 +/- 5.1 years) were divided prospectively into two groups. They were mostly high-risk patients (average number of major risk factors, 2.2 +/- 0.9). Thirty-three showed one or several signs of lithiasis of the common bile duct and were treated with endoscopic sphincterotomy (ES) (31 successful cases, two technical problems) followed by early cholecystectomy (33 cases). Choledocholithiasis was present in 26 cases and stones were extracted in 25 cases. Two patients (6 per cent) died. ES caused no complications. Thirty-one other patients showed no sign of choledocholithiasis and were treated by cholecystectomy with operative cholangiography. Choledocholithiasis was found in two of these patients and treated by extraction and external drainage. Five of these patients (16 per cent) died. In 30 cases acute cholecystitis was found at operation, 15 in each group. ES is therefore an efficient procedure in high-risk patients, which facilitates operation, especially in cases of acute cholecystitis, and it is recommended in all cases of complicated biliary lithiasis. Early cholecystectomy is justified for these patients by the high frequency of associated acute cholecystitis.

Aged↗
PubMed1987

The arteriovenous fistula in segmental pancreatic transplantation in dogs--a hemodynamic study.

Arterial and/or venous thrombosis is a frequent complication in experimental or human pancreatic transplantation. A canine experiment was used to study the hemodynamic effects of spleno-splenic arteriovenous fistula during segmental pancreatic transplantation. An increase in blood flow, without "steal" syndrome in the pancreatic blood supply or pressure increase, was found. Thus this technique can help prevent vascular thrombosis in pancreatic transplant in dogs.

Animals↗
PubMed1986

[Revascularization of the 2 lower limbs from the descending thoracic aorta without laparotomy].

Arterial bypass of the lower limbs from the thoracic aorta approached through a thoracic or abdominal route has already been described. The technique reported here is original in that the descending thoracic aorta is exposed through thoracotomy, and the prosthesis is passed behind the left kidney, then, for the right leg bifurcation, through Retzius' space without laparotomy. Two patients were operated upon with this technique which is described in detail, together with its potential indications, advantages and disadvantages.

Aged↗
PubMed1986

[Heterotopic segmental autotransplantation of the pancreas with digestive system anastomosis in the dog].

Segmental autotransplantation of pancreas in the heterotopic position, with digestive anastomosis protected by an epiploplasty was performed in a series of 22 dogs. Twenty dogs survived the operation and nine were followed up for 4 weeks: the histologic and morphologic qualities of the graft were very favorable from both endocrine and exocrine points of view. This morphohistologic quality can be related to the digestive anastomosis performed, which failed to provoke any specific complications to a large extent. This study should be completed by improvement in the vascularization of the graft by a splenic arteriovenous fistula and a concomitant study of the endocrine function of the transplanted pancreas in dogs with experimentally-induced diabetes.

Animals↗
PubMed1984

Uridine kinase molecular species and uridine uptake in some variants of rat hepatomas.

In a family of clonal lines derived from the Reuber H 35 rat hepatoma, four electrophoretically distinct molecular forms of uridine kinase (UK I, II, III, and IV) have been characterized. They are the same as those found in foetal rat liver. Different UK profiles occur in these cell lines, and no strict correlation could be established between the state of differentiation of the cells and the form of UK expressed. A clone of somatic hybrid cells between line p4 (form 1 only) and Fu5-5 (forms II, III, and IV) that does not express form I indicates that p4 cells may lack a factor controlling the polymerization of form I. This variety of clonal cell lines was used to study the uptake and phosphorylation of labeled uridine. The results suggest a relationship between the UK form present and the rate uridine phosphorylation by the intact cells.

Animals↗
PubMed1981

[Amineptine and amotival syndrome (author's transl)].

Intellectual, affective and motor inhibition is part of the syndrome encountered in: drug withdrawal in addicts especially with opiates; hebephrenia. Amineptine a new antidepressant agent with psychoanaleptic properties has been studied in these patients. Considering this psychotonic activity was logical to test both the tolerance of this compound in drug addicts and the risk of delirious reactivation in schizophrenic patients. The open study in 19 patients shows an effect of amineptine: -on inhibition and loss of activity, apragmatism and deterioration of social behaviour; -a subjective improvement of intellectual performance. And moreover: without reactivation of preexisting delirious ideas in schizophrenic patients; without drug addiction in treated toxicomaniacs.

Adult↗
PubMed1980

Electrophoretically distinct forms of uridine kinase in the rat. Tissue distribution and age-dependence.

By the use of polyacrylamide-gel electrophoresis, uridine kinase from foetal rat liver was separated into four types designated I, II, III and IV in decreasing order of mobility towards the anode. The most anodic (type I) was found only in rapidly growing tissues, such as foetal liver and brain, postnatal spleen and tumour cells. In adult tissues, types II, III and IV were found in the kidney, and types III and IV in the spleen and the liver, whereas type IV was the sole form of uridine kinase present in the brain.

Age Factors↗
PubMed1978

[Carpipramine and drug addiction].

This study is related to the therapeutic effects of Carpipramine in conditions of pharmacodependance to opiates. The withdrawal in 47 subjects by decreased doses of methadone, clinically presenting 42 amotivational syndroms and 5 depressions. On the other hand, 3 withdrawal trials using chimiotherapy, including Carpipramine, failed. Carpipramine seems to have an important disinhibitory effect in amotivational syndrom and tolerance is excellent. Lack of desire for this psychotropic drug makes its use safe by drug addicts.

Adult↗
PubMed1976

Uridine--cytidine kinase from foetal and adult rat liver. Purification and study of some properties.

Partial purification of uridine--cytidine kinase (EC 2.7.1.48) from foetal rat liver by chromatography on DEAE-cellulose gives two active fractions. The first in order of elution was identified as a form specific for foetal liver. It was purified 300-fold. The second fraction was common to foetal, and adult rat liver and spleen and was purified 20-fold. The foetal fraction of the enzyme was found to be heat-sensitive and protected against inactivation by PO34- anions. The two isolated forms have different apparent Km for uridine, respectively 410 muM for the foetal form and 52 muM for the adult form.

Animals↗
PubMed1975

Desoxyribonucleic acid and pyrimidine synthesis in the rat during intra-uterine growth retardation: responsiveness of several organs.

The response of DNA synthesis, thymidine incorporation and the activities of uridine kinase, carbamyl phosphate synthetase and aspartate transcarbamylase were studied in the rat, following intra-uterine growth retardation. A good correlation was found between the falls of DNA production and thymidine incorporation and the decrease of the activity of the three enzymes during the fetal period. After birth, cell proliferation remained depressed but no further changes occurred in the enzymatic activities.

Animals↗