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Biomedical subjects

J M Rush

Publications and source records attributed to J M Rush.

7 recordsLinked to original sources
PubMed1998

Assessing sensory blockade with alcohol and pinprick after subarachnoid block.

The purpose of this study was to determine the accuracy of alcohol swabs in assessing dermatome levels in comparison to pinprick after subarachnoid block. Room temperature alcohol swabs and pinprick were used to determine dermatome levels at 5, 10, and 15 minutes after a 15-mg hyperbaric bupivacaine subarachnoid block was administered with the patient in the sitting position. The sample population consisted of 53 men scheduled for elective transurethral resection of the prostate or bladder tumor with an ASA classification of I to IV. Subjects were assessed while they were in the preoperative holding area for the ability to discriminate pinprick and cold sensation. Data were analyzed using the Wilcoxon signed rank test. There was a statistically significant difference between alcohol and pinprick at the 10- and 15-minute assessments. (P < .05).

Aged↗
PubMed1982

Termination of mid-trimester pregnancy with intramuscular 15-(S)-15-,methyl-prostaglandin F2 alpha.

Termination of mid-trimester pregnancy was successfully achieved in 30 patients with 15-(S)-15-methyl-PGF 2 alpha administered by repeated intramuscular injections. All patients aborted within 48 hours and the majority (73%) aborted within 24 hours. The mean induction-abortion interval was 19 affected by parity but was marginally shorter in patients at an earlier stage of gestation. The average total dosage of 15-methyl-PGF 2 alpha was 2075 micrograms (or 8,3 injections) per patient. Vomiting (93,9%) and diarrhoea (73,3%) were the only troublesome side-effects but they were not severe and were well tolerated by the patients. The incidence of vomiting was reduced with prophylactic drugs.

Abortifacient Agents↗
PubMed1982

Intramuscular and extra-amniotic 15-(S)-15-methyl-prostaglandin F2 alpha in intra-uterine death.

The efficacy of 15-(S)-15-methyl-PGF2 alpha in inducing labour in 30 patients with intra-uterine fetal death was tested. The patients were divided into two groups of 15 patients and the drug was administered either by repeated intramuscular injection or by continuous intra-uterine extra-amniotic infusion. The extra-amniotic method of administration was the safest and most successful method (100% v. 93,3%); the duration of labour was shorter (mean 12 hours 39 minutes v. 17 hours 39 minutes); less prostaglandin was required (mean 867 micrograms v. 2300 micrograms); and it was associated with the lowest incidence of side-effects compared with the intramuscular route of administration (no vomiting; 6,6% incidence of diarrhoea v. 60% vomiting and 73,3% diarrhoea). The intramuscular method was further complicated by 1 case of uterine rupture.

Adolescent↗
PubMed1982

Missed abortion treated with intramuscular 15-(S)-15-methyl-prostaglandin F2 alpha.

Repeated intramuscular injections of 15-(S)-15-methyl-PGF2 alpha were administered to 15 patients with a missed abortion. Fourteen (93,3%) aborted within 24 hours, with a mean induction abortion interval of 10 hours 54 minutes. The single failure occurred in a patient with a placenta accreta. The induction abortion interval was marginally shorter in patients at an early stage of gestation and was not affected by parity or the duration of fetal death. The average total dosage of 15-methyl-PGF2 alpha was 1250 micrograms (or 5 injections) per patient. The side-effects consisted of vomiting (71%), diarrhoea (71%), leucocytosis (64,3%) and transient pyrexia (21,5%), but these were not severe and were well tolerated by the patients.

Abortion, Missed↗
PubMed1981

A comparison of meptazinol and pethidine for pain relief during the first stage of labour.

Meptazinol and pethidine were compared in a double-blind randomized trial with regard to analgesia during the first stage of labour. It was concluded that neither drug is effective for sustained pain relief, and that there is no advantage of one over the other. However, neither drug affected maternal condition as reflected by respiratory rate, pulse rate and blood pressure, nor was any detrimental effect noted on the condition of the newborn infant. The critical reassessment of traditional drugs for analgesia in labour is suggested.

Azepines↗