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J M Santaularia

Publications and source records attributed to J M Santaularia.

15 recordsLinked to original sources
PubMed2006

[Usefulness of the present renal cell carcinoma classifications].

The purpose of classifying neoplasias is to recognize groups with similar progress and prognosis and, if possible, receiving the same treatment. This is why those classifications are systematically being submitted to review and improvement through the new technologies. Differentiation of various entities in renal cancer has been comparatively fast, as the new genetic and molecular discoveries have confirmed the morphologic criteria of the different cell types, thus making it possible to open new therapeutic pathways. Using the current WHO classification we recognize subtypes with excellent prognosis (Multilocular cystic renal carcinoma, Type I renal papillary carcinoma, Tubular and fusocellular mucinous carcinoma), other very aggressive ones (Bellini's collecting duct carcinoma, Medullary carcinoma), and also that the sarcomatoid transformation, even in small areas, impacts the prognosis negatively. Childhood-characteristic renal carcinomas associated with chromosome translocations have been recognized (genetic fusion TFE3 or TFEB), as well as the family forms of renal carcinoma. Regarding the UICC (International Union Against Cancer) classification, there are a series of aspects under argument (size, venous invasion, microvascular invasion, invasion of the adipous tissue of the renal sinus) that shall be discussed too, since it is possible that some modifications of the TNM might occur in the near future.

Adenocarcinoma, Mucinous↗
PubMed1993

[Cytogenetic characteristics and of primary culture in multiple renal tumors].

The incidence of multiple tumours in renal cancer ranges between 1 and 30%. In these cases, it becomes very difficult to differentiate between adenoma and carcinoma just by using conventional methods, particularly in borderline cases. We carried out primary cultures and subsequent cytogenetic studies in 2 patients with multiple renal cancer. Clonal numerical changes in the first case were: 3, 7, 16 and 17 trisomies, chromosome loss; and structural changes, del(1) (p34), del(2) (p16, p22). In the second case, clonal numerical changes were 7 trisomy and tetrasomy and loss of the Y chromosome. Both tumours were cytogenetically characterized as papillary renal tumours. The diagnostic approaches are discussed and the prognosis possibilities evaluated, using this method to evaluate them in multiple renal tumours.

Chromosome Aberrations↗
PubMed1992

[Multiple organ metastasis following nephrectomy for renal carcinoma].

We report a case of TNM stage II renal carcinoma with metastasis to lungs, contralateral adrenal gland and skin within 5 years following nephrectomy. The patient underwent lobectomy, adrenalectomy and cutaneous excision biopsy. The clinical course and management of metastases are discussed.

Adenocarcinoma↗
PubMed1992

[A nephrogenic adenoma during treatment with intravesical BCG].

Two patients who had undergone resection of a transitional cell bladder tumor presented with nephrogenic adenoma of the bladder during treatment with BCG. Nephrogenic adenoma presenting in the course of intravesical chemotherapy has been previously reported in 5 cases and can mimic tumor recurrence. Thus, we consider the present case to be of special interest.

Adenoma↗
PubMed1986

Balanitis xerotica obliterans in children.

This report is based on 7 children with balanitis xerotica obliterans. Of these patients 5 had stenosis of the urethral meatus that required meatotomy and the postoperative results were good. The frequency of balanitis xerotica obliterans in children at our center, as well as the findings of other authors, suggests that possibly more cases would be diagnosed during infancy if all dried foreskin were examined systematically.

Adolescent↗
PubMed1986

Testicular pseudolymphoma.

Pseudolymphomas are reactive processes which by their morphology can be confused with lymphomas. They have been described in non-lymphoid organs (gastrointestinal tract, lung, breast, etc.), although cases have also been reported in the spleen. In this article we present the case of a 3-year-old child in whom the location was in the testes. It is the 4th case reported in the literature and the first in a child. The main criteria for establishing such a diagnosis are the delimitation of the lesion, the presence of mature lymphocytes intermingled with other cells which are mainly plasma cells of polyclonal type and the formation of lymphoid follicles with active germinal centers. A differential diagnosis within the testicle should be made with the lymphoma (primary or secondary), the leukemic infiltration and the seminoma with marked stromal lymphoid reaction.

Child, Preschool↗
PubMed1985

Transitional cell carcinoma of the prostate.

5 cases of transitional cell carcinoma of the prostate, which represent 1.5% of a series of 323 consecutive prostatic carcinomas, are presented. The cases with possible prostatic involvement by contiguity from a bladder carcinoma as well as those tumors with a transitional pattern which contain prostatic acid phosphatase in the cellular cytoplasm have been ruled out to make the diagnosis. The mean age of the tumoral onset is 70 years with an identical symptomatology to that of the adenocarcinoma. In 20% of the cases it is associated with an adenocarcinoma and in 40% with a bladder carcinoma without contiguity. The mean survival is 10.6 months with 60% succumbing within the first 6 months. Our findings agree with all authors in considering this type of tumor an urothelial neoplasia.

Acid Phosphatase↗
PubMed1983

Metastatic tumor of the epididymis and spermatic cord.

We report a case of adenocarcinoma of the tail of the pancreas which was manifested by metastases to the spermatic cord and epididymis. 8.1% of the malignant tumors of the spermatic cord and/or epididymis are metastatic. After reviewing the literature on this subject, we found that the most frequent primary tumors metastatic to the spermatic cord and epididymis are carcinomas from the stomach (42.8%) and the prostate (28.5%). 23.8% of these metastases are subclinical and when discovered the wrong diagnosis is always made concerning the origin of the primary tumor. Only uncommonly (9.5%) are they the first sign of an occult neoplasm. In 47.6% of the cases, the metastases and the primary tumor are found simultaneously. The average survival, subsequent to the diagnosis of the metastasis, is 9.1 months.

Adenocarcinoma↗
PubMed1981

Fibrous polyp of the ureter.

The most frequent ureteral tumors are transitional carcinoma. Benign neoplasms are uncommon. In this paper we present 6 cases of ureteral polyps, which represent 11.1% of all the tumors in our series of ureteral tumors. We have reviewed the possible etiopathogenesis and exposed the clinical characteristics. Secondary to the obstructive phenomenon and the radiologic signs, it is the tigroid appearance, the localization and the absence of total obstruction which allows the diagnostic suspicion. The treatment of choice is partial resection. Ureterostomy with peroperatory biopsy, in cases in which the malignancy is not yet established, is recommended in order to avoid unnecessary nephroureterectomies.

Adult↗
PubMedDate not supplied

[Testicular malacoplakia].

This paper present the case of a patient with orchioepidimiditis quickly evolving to scrotal fistulization. The study of the orchiectomy piece showed testicle malacoplakia.

Adult↗
PubMedDate not supplied

[P. Metastasis of prostatic carcinoma to the epididymis].

When reviewing the bibliography of this rare metastatic location of cancer of the prostate gland, we have only been able to compile the observations published by HUMPHREY (1), BROTHERUS (2) and SMITH (3) wo describe cases with the same location and characteristics. All the observations of metastasis in the epididymis of cancer of the prostate gland constitute unexpected findings during the course of surgical castration operations. The morphology is always the same, small indurated nodules respecting the rest of the epididymis. On the other hand, metastases in the epididymis of extraurinary adenocarcinomas most of which were digestive, were not discovered until the increased size and pain in the testicle attracted the patient's attention and the exploration led to the identification of the tumour in the epidiymis (2, 4, 5). However, primitive malignant tumours of the epididymis constitute an infrequent lesion. In the literature there were found to be more primitive tumours in relation to the metastatic ones and it was difficult to establish the diagnosis of a primitive tumour of the epididymis without having previously ruled out the possibility of other distant neoplasias which are sometimes even asymptomatic.

Adenocarcinoma↗