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Biomedical subjects

J M Saunders

Publications and source records attributed to J M Saunders.

13 recordsLinked to original sources
PubMed1989

Psychosocial and cultural issues in HIV infection.

HIV infection is distributed so that stigmatized groups (gay and bisexual men, IVDU, blacks, and Hispanics) form the majority of cases. Consequences of AIDS-related stigma have resulted in unnecessary discrimination: loss of job, loss of home, denial of insurance, and estrangement from family and friends. Because AIDS is an infectious disease with a high mortality rate, HIV-infected individuals live with the threat of impending death. An awareness of the cultural values, life-styles, and psychosocial problems of these patients will promote effective nursing care.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Opsonophagocytic killing antibody to Pseudomonas aeruginosa mucoid exopolysaccharide in older noncolonized patients with cystic fibrosis.

The principal cause of morbidity and mortality in cystic fibrosis is persistent respiratory colonization with mucoid strains of Pseudomonas aeruginosa. To investigate possible mechanisms of resistance to this organism, we studied serum from 16 older (greater than or equal to 12 years) patients not colonized with mucoid P. aeruginosa, 11 older (greater than or equal to 14 years) colonized patients, 10 younger (less than or equal to 11 years) noncolonized patients, and 20 healthy adults. The samples from the older patients not colonized with mucoid P. aeruginosa contained antibody specific to the mucoid-exopolysaccharide antigen, which could mediate bacterial killing in conjunction with complement and white cells (titers of 4 to 80). These opsonophagocytic killing antibodies were not detected in samples from the 20 normal controls (P less than 0.0001 vs. noncolonized older patients) or 9 of 10 younger (less than or equal to 11 years) noncolonized patients (P = 0.0072 vs. noncolonized older patients). Although the patients with chronic colonization had higher titers of serum opsonophagocytic killing antibody than did the older noncolonized patients (P = 0.0005), these antibodies were not specific to the mucoid-exopolysaccharide antigen. We conclude that there is an association between mucoid-exopolysaccharide-specific opsonophagocytic killing antibody and a lack of detectable P. aeruginosa colonization in a subset of older, relatively healthy patients with cystic fibrosis.

Adolescent↗
PubMed1987

An immunohistological evaluation of Pseudomonas aeruginosa pulmonary infection in two patients with cystic fibrosis.

Pseudomonas aeruginosa is the principal pulmonary pathogen in patients with cystic fibrosis. All attempts to date to prevent or eradicate P. aeruginosa infections in these patients have been unsuccessful. Vaccination against P. aeruginosa has been proposed as a preventive strategy but it has not been adequately evaluated. The purpose of this study was to determine whether P. aeruginosa, present in the lungs of patients with cystic fibrosis, express surface antigens similar to those grown in vitro; this issue is of critical importance when choosing bacterial products as vaccine candidates. Lung sections from two patients who died of the pulmonary complications of cystic fibrosis were studied. Bacteria, both in lung sections and isolated from the lung sections and grown in vitro, reacted strongly with polyclonal and monoclonal antibodies against P. aeruginosa mucoid exopolysaccharide and outer membrane proteins F and H2; this suggested that these antigens are surface exposed in vivo. It was also found that bacteria in both lung sections were associated in situ with IgG, IgA, and C3 but not with IgM or C4.

Antibodies, Bacterial↗
PubMed1986

Immunoblot analysis of antigens associated with Haemophilus ducreyi using serum from immunised rabbits.

Sodium dodecyl sulphate polyacrylamide gel electrophoresis and immunoblotting were used to characterise isolates of Haemophilus ducreyi. Isolates of H ducreyi were heterogeneous in protein composition, but isolates from single outbreaks appeared similar both in protein profiles and antigenic analysis. Rabbits immunised with H ducreyi responded with a vigorous humoral immune response in which multiple antigenic polypeptides were detected. The most prominent antigens had molecular masses of 67, 42, 22.5, and 20 kilodaltons.

Animals↗
PubMed1979

A versatile antipollution device.

Removal of anaesthetic pollutants from the operating theatre environment requires the use of relatively sophisticated equipment which must be added to an existing life support system (the anaesthetic machine). The interface is only one part of this system and to be safe and satisfactory it must be as simple and versatile as possible and be designed in such a way as to render incorrect connection and use virtually impossible.

Air Pollutants↗
PubMedDate not supplied

HIV infection. Helping adolescents choose safer behaviors.

Although adolescents comprise only 1% of the diagnosed cases of acquired immune deficiency syndrome (AIDS), the risk of human immunodeficiency virus (HIV) infection among this group should not be underestimated. This article discusses how adolescents' behaviors place them at risk for HIV infection. One educational program is described that illustrates an innovative approach to use with adolescents. Nurses who use the Relationship Safety and Vigilance Plan can assist individual adolescents to assess their interpersonal relationship patterns to establish goals and reduce impulsive or destructive behaviors.

Adolescent↗
PubMedDate not supplied

Cancer and suicide.

Explore the source record for details and available documents.

Depression↗