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J M Seidman

Publications and source records attributed to J M Seidman.

6 recordsLinked to original sources
PubMed1980

Yellow nail syndrome: complete triad with pleural protein turnover studies.

Lymphedema, pleural effusions, and yellow nails constitute the yellow nail syndrome, which commonly is associated with chronic lower respiratory infections and sinusitis. Of 50 cases reported, only 13 have had the complete triad; we report another. The patient has a history of bronchiectasis, bilateral leg lymphedema, and yellow nails since 1952, with recurrent effusions since 1953. She has other conditions which are reported in high frequency with the syndrome, including sinusitis, thyroiditis, and malignancy. An albumin turnover rate was determined on the pleural effusion by a radioactive tracer method.

Aged↗
PubMed1978

Light and electron microscope study of osmotically induced tumor necrosis.

Necrosis of 1.5-cm Walker 256 tumors was produced by injecting a strongly hypertonic solution of glucose in and around the growths and by delaying resorption of the solution with serotonin, given s.c. at a distance. The morphological changes occurring in 13 tumors were followed by light and electron microscopic analysis of samples taken 0.25, 0.5, 1, 1.5, 3, and 5 hr after treatment. The 0.25-hr samples showed mitochondrial swelling, loss of cristae, and flocculent material within the inner compartment. Swelling of the mitochondria persisted in the 0.5-hr specimens (as it did in all subsequent samples), and it was accompanied by clumping and margination of chromatin. These changes were more pronounced at 1 hr, at which time the nuclear and plasma membranes were frequently ruptured. The endoplasmic reticulum and Golgi complex could no longer be recognized. The 3-hr material revealed ruptures of the outer mitochondrial membrane with myelin figures and discontinuous cell membranes. In the 5-hr samples, the nuclei exhibited a dark nucleoplasm and large clumps of chromatin. The perinuclear membrane was not always recognizable.

Animals↗
PubMed1977

Induction of acute necrosis in Walker 256 tumors in rats.

The destructive effect on cells of locally injected hypertonic solutions, resorption of which is delayed by some vasoactive agents, was observed in the skin and subcutis of the rat by Selye and his coworkers who described it as acute conditioned necrosis. The same phenomenon was demonstrated in Walker 256 tumors implanted in the thighs of female Sprague-Dawley rats. A strongly hypertonic solution of glucose was injected once in and around the tumor (when it had reached a mean diameter of 1.5 cm), and 5-hydroxytryptamine was given s.c. at a distance. This resulted in disappearance of the growth in an average of 10 days and absence of metastases 2 months after treatment in 84% of animals as opposed to a spontnaeous regression of the tumor in 4% of control rats.

Animals↗