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Biomedical subjects

J M Singer

Publications and source records attributed to J M Singer.

62 records · Page 4Linked to original sources
PubMedDate not supplied

Clobazam versus placebo for anxiety and tension in psychoneurotic outpatients. A multicenter collaborative study.

Clobazam, a 1,5-benzodiazepine, was compared with placebo in 190 psychoneurotic outpatients with prominent symptoms of anxiety and tension of at least two weeks of duration. The design was one of double-blind parallel groups treated for one week. Clobazam subjects began on 40 mg daily in divided dosage, which was increased to 80 mg daily be day 3 if the drug was well tolerated. Two patients receiving clobazam had laboratory chemistry abnormalities which were possibly drug related. Adverse effects occurred more frequently in the clobazam group and were typical of those of marketed benzodiazepines. This study indicates that clobazam is an effective anxiolytic agent demonstrating its clinical effects during the first week of treatment.

Adolescent↗
PubMedDate not supplied

Effectiveness of three mouthrinses to inhibit acid formation by dental plaque under home-use conditions.

A study was conducted to assess the effectiveness of three mouthrinses (Plax, Cepacol and Fluordent) to inhibit acid formation from plaque collected from 21 volunteer dental students. Plaque was collected on each side of the mouth, two hours after breakfast, once-a-week, after a period of 48 hours without any oral hygiene other than the use of the mouthrinses. Initial pH and the change in pH of plaque incubated with sucrose were recorded up to 120 min. Excepting Cepacol for the first week only, no inhibitory effect on acid formation was observed.

Adolescent↗
PubMedDate not supplied

The effect of training on the ability of children to use dental floss.

The effect of training on the ability to use dental floss was evaluated in a study involving forty-eight children in the 6.5 to 7.5 age-group. Using a dental plaque index for the proximal surfaces, we observed significantly superior average results for the trained group (five weekly sessions) relative to the group with no training. We also observed a significant average difference favoring the male trained group relative to the female trained group.

Analysis of Variance↗