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Biomedical subjects

J M Singh

Publications and source records attributed to J M Singh.

At least 19 recordsLinked to original sources
PubMed1981

Clinical toxicology of clotrimazole when administered vaginally.

Clotrimazole, a tritylimidazole and a new antimicrobial agent, produced itching and irritation of the vulva and vaginal area in less than 1% of the population (N = 131) studied. No abdominal cramps, headache or lightheadedness, nausea, vomiting, and diarrhea were observed when 200 mg of clotrimazole was inserted deep in the vagina for several days.

Candidiasis↗
PubMed1975

Methadone-induced behavioral changes: circular movements, aggression, and electrophysiological aspects.

Behavioral changes are induced in animals by methadone administration. The dose-dependent CM effect is present 2 to 3 minutes after methadone administration. This effect can be partially blocked by nalline. A Complete blockade occurs when the naline-reserpine combination is given prior to the administration of methadone. Atropine sulfate dose not block the CM effect. Methadone withdrawal produces mild symptoms of aggression, and they can be intensified by amphetamine and apomorphine. During the process of development of tolerance and addiction, electrophysiological changes are produced. These changes can be intensified by apomorphine treatment in the methadone-withdrawal animals. On the basis of pharmacological manipulation in our experimental conditions, the involvement of cerebral biogenic amines, especially dopamine, is proposed.

Aggression↗
PubMed1975

Alkaloids of tobacco and blood coagulation: effect of nicotine on thrombin and fibrinogen.

An alkaloid of tobacco, nicotine, affected the clot-formation property of the enzyme, thrombin, on the substrate, plasma or fibrinogen (thrombin time). Higher concentrations of nicotine retarded the clot-formation property of thrombin. By decreasing the nicotine concentration in the clotting mixture, the clotting time of thrombin was accelerated. Nicotine also modified the clot formation property of plasma or fibrinogen to thrombin, and this effect was dose dependent. From this experimental evidence, it is suggested that nicotine does alter the clot-forming properties of thrombin on fibrinogen.

Alkaloids↗