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Biomedical subjects

J M Smeenk

Publications and source records attributed to J M Smeenk.

4 recordsLinked to original sources
PubMed2001

Stress and marital satisfaction among women before and after their first cycle of in vitro fertilization and intracytoplasmic sperm injection.

OBJECTIVE: To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). DESIGN: Repeated measurement. SETTING: Fertility department at a university and a regional hospital. PATIENT(S): Women entering their first treatment cycle of IVF or ICSI. INTERVENTION(S): Questionnaires on psychological factors were administered 3 to 12 days before the start of their first treatment cycle and repeated 3 weeks after the pregnancy test. MAIN OUTCOME MEASURE(S): State anxiety, depression, mood, and marital satisfaction. RESULT(S): At pretreatment, the women who became pregnant showed lower levels of depression than those who did not. Higher levels of depression in the pregnant women after the first cycle were due to higher scores on vital aspects of depression, related to signs of early pregnancy. Higher levels of depression in the nonpregnant women were due to a higher score on cognitive aspects of depression. CONCLUSION(S): Differences in emotional status between pregnant and nonpregnant women were present before treatment and became more apparent after the first IVF and ICSI cycle. There were no differences in emotional status between the women who underwent IVF and those who underwent ICSI.

Adult↗
PubMed2001

The effect of anxiety and depression on the outcome of in-vitro fertilization.

BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in assisted reproductive treatment. Previous studies on this topic have shown contradicting results, which may have been caused by population characteristics, the design of the study, or small sample sizes. METHODS: In a multicentre prospective study, 291 out of 359 (81%) consecutively invited women agreed to participate. Before down-regulation by means of gonadotrophin-releasing hormone (GnRH) analogues in a long IVF protocol, patients were asked to complete the Dutch version of the State and Trait Anxiety Inventory to measure anxiety, and the Dutch version of the Beck Depression Inventory (BDI) to measure depression. Multiple logistic regression analysis was used to analyse known predictors of pregnancy and psychological factors and their relationship with treatment outcome. RESULTS: A significant relationship was shown between baseline psychological factors and the probability to become pregnant after IVF/intracytoplasmic sperm injection (ICSI) treatment, controlling for other factors. State anxiety had a slightly stronger correlation (P = 0.01) with treatment outcome than depression (P = 0.03). CONCLUSIONS: Pre-existing psychological factors are independently related to treatment outcome in IVF/ICSI, and should therefore be taken into account in patient counselling. Psychological factors may be improved by intervention, whereas demographic and gynaecological factors cannot. Future studies should be directed towards underlying mechanisms involved and the role of evidence-based distress reduction in order to improve treatment results.

Adult↗
PubMed2000

External validation of the templeton model for predicting success after IVF.

This study aimed to externally validate the prognostic model presented by Templeton in 1996 for live births resulting from IVF treatment. Data were used from the University Hospital, Nijmegen, The Netherlands, from March 1991 to January 1999. The predictive capacity of the model in our population discriminated between those women with a low probability of success and those with a relatively high probability. Despite these encouraging findings, our data show that implementation of the model in clinical decision-making remains difficult. The Templeton model is not applicable or usable in daily clinical practice, because the model did not give more information about the prognosis for the vast majority of the patients. Therefore, the search for better prognostic factors resulting in better predictive models should continue.

Adult↗