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Biomedical subjects

J M Sowa

Publications and source records attributed to J M Sowa.

10 recordsLinked to original sources
PubMed1992

HTLV-I myelopathy.

Explore the source record for details and available documents.

Brain Diseases↗
PubMed1992

Human T lymphotropic virus I, myelopathy, polymyositis and synovitis: an expanding rheumatic spectrum.

A black woman developed chronic myelopathy, polymyositis and synovitis. Although native of a nonendemic area the possibility of human T lymphotropic virus I association was considered. She tested positive and was serendipitously found to have been positive 16 years before. Risk factors were a transfusion and work as a serology technician. Sjögren's syndrome, alveolitis, gammopathy and immune dysfunction are other rheumatic manifestations of this virus.

Antibodies, Viral↗
PubMed1975

Myelomonocytic leukaemia following cyclophosphamide therapy of rheumatoid disease.

A 69-year-old woman treated for 31 months with daily oral cyclophosphamide for refractory rheumatoid disease developed acute myelomonocytic leukemia 21/2 years after stopping the drug. The possibility of a casual association between the therapy and subsequent leukaemia is supported by the growing experience with cytotoxic agents.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Controlled trial of cyclophosphamide in rheumatoid arthritis.

Twenty-four patients with severe progressive rheumatoid arthritis were randomly assigned to cyclophosphamide or placebo in a double-blind crossover trial. Eleven patients who completed 9 months on cyclophosphamide (average dose: 1.8 mg/kg/day) demonstrated significant decrease in painful joints, swollen joints, and morning stiffness and increase in grip strength when compared to 11 patients on placebo. After crossover, significant improvement was observed in patients switched to cyclophosphamide, and deterioration within 2 months was observed in most patients changed from drug to placebo. Serum immunoglobulins and rheumatoid factor titers decreased with cyclophosphamide but antibody response to Vi antigen was unaffected. Primary delayed immune response to 2,4-dinitrochlorobenzene was markedly depressed. Adverse effects were troublesome--hemorrhagic cystitis affected 4 patients and amenorrhea occurred in 3. Despite striking beneficial effect, cyclophosphamide should be prescribed cautiously and only in severe resistant cases of rheumatoid arthritis.

Adult↗