Biomedical subjects
J M Starr
Publications and source records attributed to J M Starr.
Senile hypertension and cognitive impairment: an overview.
PURPOSE: Both hypertension and cognitive impairment are common disorders in old people. This paper reviews epidemiological, clinical and experimental studies that have examined the association between these conditions. CONTENTS: Evidence is presented which suggests that raised blood pressure levels contribute to cognitive impairment in susceptible people, particularly those with concomitant conditions which predispose them to cerebral ischemia. Some studies have demonstrated that certain classes of antihypertensive drugs may have beneficial actions on ischaemic and cell growth processes, while others may tend to impair cognitive function, either by central actions or by alterations to cerebral blood flow. CONCLUSIONS: A successful approach to the treatment of hypertension-associated cognitive impairment is likely to follow a detailed analysis of risk factors in the individual patient. Fundamental epidemiological work is required to clarify genetic components or risk, and more long-term treatment trials would also be helpful, although these have proved problematic in the elderly. At present, although it is clear that old people with hypertension should be treated, whether or not they are also cognitively impaired, further studies are necessary to decide on the best antihypertensive therapy for this substantial population.
Continuous, in vivo pulmonary venous admixture from fiberoptically measured hemoglobin saturations.
In six anesthetized swine, pulmonary venous admixture (Qsp/Qt) was calculated by four methods: a) Qsp/Qt 1, fiberoptically measured arterial and mixed venous Hgb saturation (SaO2 and SvO2), PaO2 and PvO2 derived from saturations; b) Qsp/Qt 2, fiberoptically measured SaO2 and SvO2, PaO2 and PvO2 measured by blood gas analysis; c) Qsp/Qt 3, PaO2 and PvO2 measured by blood gas analysis, SaO2 and SvO2 derived from tensions; d) Qsp/Qt 4, SaO2 and SvO2 measured by bench oximetry, PaO2 and PvO2 derived from saturations. Input from the fiberoptic catheters was fed into a computer programmed to calculate Qsp/Qt 1 every 20 sec. Fifty-eight of these values were compared with simultaneously calculated Qsp/Qt 2, 3, and 4. There was no difference between fiberoptic and derived SaO2 or fiberoptic and cooximetric SvO2. Correlations and slopes for Qsp/Qt 1 with Qsp/Qt 2, 3, and 4 were significant (p less than .05). Comparing mean differences, Qsp/Qt 1 was significantly different only from Qsp/Qt 3 (p less than .01). We conclude that dual oximetry reliably tracks Qsp/Qt.
Central venous hemoglobin saturation inaccurately estimates SvO2.
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Individualized matrix bands for amalgam restorations.
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So you would like to be a dentist.
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Hygienist to dentist? Why not?
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