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Biomedical subjects

J M Suduca

Publications and source records attributed to J M Suduca.

10 recordsLinked to original sources
PubMed2001

[Chronic perineal pain].

Chronic perineal pain, too easily considered in the past as psychogenic, has undergone significant reshapings in recent years because of a better understanding of pathophysiology. Progress in functional investigations, especially electrophysiological tests, has allowed to define new clinical entities such as pudendal neuralgia or pain linked to pelvic floor disorders. Treatments have been improved, but remain empirical outside these well defined entities. In practice, clinical examination is the main diagnostic step, which allows to exclude common anorectal or pelviperineal lesions, and to consider additional investigations. However diagnosis may remain entirely clinical in some typical presentations.

Electrophysiology↗
PubMed1991

[Practical indications for anorectal manometry].

Anorectal manometry has taken on an important role in the investigation of functional anorectal disorders. This investigation studies the two factors, the resistive system and the capacitive system, involved in anorectal function, continence and defecation. Practical indications can be grouped into three categories concerning different aspects of physiopathological, diagnostic and therapeutic interest. Manometry is essential in the investigation of disorders of pelvic static function, is useful in colorectal surgery and of interest in a wide range of proctological diseases.

Anus Diseases↗
PubMed1988

Effect of propranolol on metabolic activity of the liver in patients with alcoholic cirrhosis.

Many studies have been performed to investigate the haemodynamic effects of propranolol. However, little is known of its actions on the metabolic activity of the liver. This study aimed to investigate the influence of propranolol on hepatic function as assessed by the galactose elimination capacity (GEC) and the intrinsic clearance of indocyanine green (ICG). 15 patients with biopsy-proven alcoholic cirrhosis and portal hypertension were studied. 10 had GEC and ICG clearance measured before and after the i.v. injection of 15 mg of propranolol (group P) and 5 had ICG clearance measurement before and after normal saline injection (group C). Propranolol significantly reduced heart rate (P less than 0.005) and the porto-hepatic pressure gradient (P less than 0.01). Hepatic blood flow was not changed. GEC was not altered by propranolol. Propranolol decreased the intrinsic hepatic clearance of ICG as determined by the 'sinusoidal' model by 12% (P less than 0.01). This suggests that propranolol may have an inhibitory action on the hepatic elimination of ICG that is independent of any effect on total liver blood flow or drug metabolism, since intrinsic clearance is not influenced by changes in blood flow and ICG is thought not to be metabolized.

Female↗
PubMed1984

[Inverted polypoid hamartoma of the rectum].

The inverted polypoid hamartoma of the rectum (IPHR) is characterized by polypoid masses composed of ectopic glands of Lieberkühn invaginated within the mucosal muscle to form a conglomeration in the submucosa, hence the term "inverted polyp". It produces an unremarkable rectal syndrome, more suggestive, when abundant glairy exudate is observed, in young subjects. It causes a unique sessile polypoid lesion, occasionally multilobular or a stenotic, approximately circular, ring. Diagnosis is made using deep surgical biopsies. Two theories, dysgenetic or acquired, attempt to explain the pathogenesis of this lesion. The predominant acquired theory includes IPHR in the "solitary rectal ulcer" syndrome which is related to the traumatism of rectal prolapse. Transanal ablation is the predominant treatment.

Adolescent↗
PubMedDate not supplied

[The value and limitations of biofeedback in ano-rectal pathology].

Biofeedback, an instrumental training technique, enables the understanding and correction of a physiological mechanism, anorectal function in the present case. Correction of a functional abnormality seen as being responsible for a symptom involves the interplay of several factors within biofeedback, in particular the link between symptoms and functional abnormalities and the relationship existing between the trainer and trainee, the relative importance of which is difficult to identify. Initiation of such rehabilitation requires full clinical and functional evaluation in order to determine the indications and type of training programme required. Terminal constipation and incontinence are the chief indications providing useful results. This technique must be envisaged in the context of global management of perineal status as a whole, concomitantly with medical and surgical treatment.

Anus Diseases↗