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Biomedical subjects

J M Svigos

Publications and source records attributed to J M Svigos.

16 recordsLinked to original sources
PubMed1991

A normal 46,XX infant with a 46,XX/69,XXY placenta: a major contribution to the placenta is from a resorbed twin.

A predominantly triploid 69,XXY placenta was found associated with a normal 46,XX infant. Therefore, a triploid placenta is apparently capable of supporting normal fetal development. The chromosome and pathological results support the conclusion that the triploid placenta originates from a 'vanishing twin' pregnancy. This case is unusual in that persistence of the placenta from the vanished twin has virtually replaced most of the normal placenta.

Amniocentesis↗
PubMed1990

Silastic cup vacuum extractor or forceps: a comparative study.

A retrospective analysis over a 2-year period was carried out to compare the limitations in the use of the Silastic Cup vacuum extractor and forceps as the preferred instrument for operative vaginal delivery. Whilst the use of the vacuum extractor was associated with less maternal morbidity (54.9% episiotomy rate; 20.9% nil analgesia) and comparable neonatal problems, an increased failure rate (6.5%) was demonstrated in comparison to forceps delivery (0.7% failed vaginal delivery rate). A comparison of their use for rotational vaginal delivery failed to reveal any significant difference in maternal or neonatal outcome apart from an increased failure rate (30%) to complete vaginal delivery after application of the vacuum extractor. It is concluded that the vacuum extractor is a comparable instrument for midcavity or lift-out instrumental delivery but Kielland's forceps may still be a more appropriate instrument for rotational vaginal delivery.

Delivery, Obstetric↗
PubMed1989

Osteodysplastic primordial dwarfism: report of a further case with manifestations similar to those of types I and III.

We describe a male infant with microcephalic osteodysplastic primordial dwarfism. The clinical and radiological manifestations most closely resemble those of the patient described by Winter et al. to have manifestations overlapping with both osteodysplastic primordial dwarfism types I and III. The classification of the patient within the spectrum of osteodysplastic primordial dwarfism is discussed and the distinctive neuropathology documented.

Abnormalities, Multiple↗
PubMed1987

Early midtrimester oligohydramnios: a sign of poor fetal prognosis.

The outcome of 6 pregnant women with second trimester oligohydramnios in the absence of ruptured membranes before 20 weeks' gestation is reported. The overall prognosis of these pregnancies was poor with only 2 survivors. Review of the literature confirms the poor outcome of such pregnancies.

Abnormalities, Multiple↗
PubMed1984

Epilepsy and pregnancy.

A retrospective study of 75 pregnant epileptic women compared with a parity, age and socioeconomic matched control group of women is presented. Deterioration of control of epilepsy during pregnancy occurred in 24% of women. Statistically significant obstetric complications noted were anaemia, premature labour, premature rupture of the membranes and postpartum haemorrhage. There was 2.5-fold increase in the incidence of congenital anomalies in the neonates, an increase in feeding difficulties and a reduced incidence of jaundice. There was no maternal or perinatal death. Refinements in management may further reduce the maternal and fetal morbidity in epileptic women who choose to become pregnant.

Anemia↗
PubMed1979

The influence of insemination timing and semen characteristics on the efficiency of a donor insemination program.

The analysis of accumulated data from conceptional and nonconceptional ovulatory menstrual cycles of patients undertaking artificial donor insemination has allowed some observations to be made on the practical aspects which may influence the efficiency of the program. The evidence suggests that with the use of preserved semen, accurate timing of insemination is essential, and that days 0 and +1 with respect to the luteinizing hormone surge appear to be advantageous as compared with closely related days. When the numbers of motile spermatozoa which were inseminated over a critical 4-day interval were analyzed, the results also suggested that improved conception rates occurred when larger numbers of active spermatozoa were used. A comparison was made between those patients who had been inseminated on a single occasion and those inseminated on more than one occasion during the periovulatory period. The results obtained from those cycles inseminated on a single occasion were inferior to those obtained from cycles inseminated more than once. Finally, some limited comparison is drawn between the established insemination programs of bovine husbandry and the relatively inefficient human experience. One explanation may lie in the wider spectrum of donor semen desirable for the human programs.

Cell Count↗
PubMed1978

Prognostic aspects of endometrial carcinoma.

A retrospective analysis of 91 patients with endometrial carcinoma is presented with emphasis on important factors in relation to survival. Patients with Stage 1 carcinoma were treated with a standardized mode of preoperative radiation and extended abdominal hysterectomy. An 87.1% 5-year survival rate was obtained for patients with well differentiated lesions, with only 1 patient developing a vault metastasis. The assessment of residual tumour after intracavity radiotherapy proved reliable in predicting prognosis and should prove of benefit in directing additional therapy for endometrial carcinoma.

Adenocarcinoma↗
PubMed1977

Phaeochromocytoma and pregnancy: a case report.

A case of maternal death associated with phaeochromocytoma is reported. Diagnostic difficulty and the poor maternal and fetal prognosis are discussed. A note of caution about inadvertent use of sympathomimetic agents in such patients is included in the discussion.

Adult↗
PubMed1977

Assessment and treatment of female urinary incontinence by cystometrogram and bladder retraining programs.

One hundred female patients complaining of urinary incontinence without evidence of associated disease or urinary infection were assessed by clinical appraisal and by simple cystometrogram. Discrepancies were apparent between the two methods of patients assessment. Treatment was primarily based on cystometrogram patterns, and included the surgical correction of the urethrovesical defect, the institution of a program of micturition retraining, or a combination of both methods. Based on a short follow-up assessment period, of those 68 patients chosen for surgery, 78% were cured and 91% were markedly improved. Bladder retraining programs alone were instituted for 32 patients, and a marked (72%) improvement rate was demonstrated. It is suggested that the cystometrogram has an integral and essential place in the assessment of female urinary incontinence and may be easily integrated into practice. Bladder retraining programs may be most usefully employed for some patients found to have bladder dysfunction.

Female↗
PubMed1976

Linear and quantitative migration of stored sperm through cervical mucus during the periovular period.

The ability of stored spermatozoa to penetrate fresh samples of cervical mucus obtained from 23 patients during 47 menstrual cycles was studied, utilizing an in vitro test. The determination of daily hormonal and gonadotropin values allowed an accurate realationship to be established between the results of sperm-mucus interaction and the environmental milieu. Cervical mucus was found to be effectively penetrable only on day -1 and day 0 when considered with respect to the plasma luteinizing hormone surge. Correlation was apparent between the ability of sperm to penetrate and the favorable clinical parameters of cervical assessment.

Cervix Mucus↗