Biomedical subjects

J M Van Geelen

Publications and source records attributed to J M Van Geelen.

2 recordsLinked to original sources

PubMed1984

Female urethral pressure profile; reproducibility, axial variation and effects of low dose oral contraceptives.

The variability of the female urethral pressure profile as determined with the microtransducer technique was studied in a group of healthy nulliparous women according to a standardized methodology. Estimation of the short term reproducibility, as well as investigation of which of several serially recorded urethral pressure profiles can be considered as most representative of the basal condition, was carried out by performing serial urethral pressure profile recordings within the same study session in 12 women. Estimation of the long term reproducibility and investigation of the influence of axial rotation of the transducer membrane on the measurements were carried out in 20 women who were on low dose oral contraceptives. No influence of low dose oral contraceptives on the urethral pressure profile measurements could be detected. When serial recordings were made within the same study session, the lowest values for the urethral closure pressure were generally observed in the 3rd and 4th recordings. The short term and long term reproducibility of urethral pressure profile measurements were generally the same for the measurements in both the supine and the sitting positions. Rotation of the transducer membrane as well as positional changes significantly influenced the urethral pressure profile recordings. The recordings in which the transducer was oriented ventrally generally showed a shorter urethral length and a higher closure pressure than those in which the pressure transducer was oriented laterally or dorsally. These observations as well as the observations made during dynamic testing indicate an asymmetrical distribution of urethral closure forces in healthy nulliparous women.

Adult↗

PubMed1981

Urodynamic studies in the normal menstrual cycle: the relationship between hormonal changes during the menstrual cycle and the urethral pressure profile.

The influence of endogenous gonadal steroids on the urethral pressure profile (UPP) was studied in 27 healthy nulliparous women with the normal ovulatory cycles. The UPP and hormonal values were recorded in the follicular phase, at midcycle, and early and late in the luteal phase. Simultaneous urethrocystometry was performed by means of the microtransducer technique, according to a precise standardized methodology. The parameters of the UPP, as defined by the Standardization Committee of the International Continence Society, and the area under the urethral closure pressure curve (integrated pressure) were calculated. Reproducibility of the UPP measurements was evaluated. In addition to a basal body temperature (BBT) chart, serum levels of 17 beta-estradiol (E2), progesterone (P), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were measured at each study session in order to confirm a normal ovulatory pattern for that cycle and for comparison with the urodynamic parameters. The mean values and standard deviation of the UPP parameters in healthy nulliparous women in the supine and sitting positions are presented. Values of the pressure measurements obtained during one menstrual cycle did not change systemically with the hormonal alterations. At midcycle and early in the luteal phase, however, and anatomic and functional lengths of the urethra were consistently increased over those found in the early follicular and late luteal phases. The data suggest a causal relationship between the changes in serum E2 concentrations and the changes in urethral length.

Adult↗