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Biomedical subjects

J M Van Lis

Publications and source records attributed to J M Van Lis.

7 recordsLinked to original sources
PubMed1979

Calcium deposits in the perineurium and their relation to lipid accumulation.

Calcification of the perineurium in sural nerves occurs in human adults. Deposits of calcium salts can be found focally in the middle and outer layers of the perineurium. Evidence indicates that this calcification is related to nerve fibre breakdown and to the local presence of lipids in the perineurium. The origin of the lipids may be senescent cells or degradation myelin.

Adolescent↗
PubMed1977

Immunofluorescence studies in a case of rheumatoid neuropathy.

Findings in a sural nerve biopsy from a patient with rheumatoid neuropathy are reported. Inflammatory changes in different stages were observed in epineurial arterioles. Arterioles with fibrinoid necrosis contained IgG, IgM, rheumatoid factor and complement. The same substances were found at the inner site of the perineurial sheaths. It is suggested that these proteins leaked out of endoneurial vessels and became trapped in the perineurial sheaths. With anti-herpes simplex virus serum fluorescence was seen in monuclear cells of infiltrated vessel walls. This virus could not be isolated in tissue culture.

Aged↗
PubMed1977

Plasma proteins in human peripheral nerve.

Using the immunofluorescent technique, the distribution of nine plasma proteins, differing in molecular weight, was studied in sural nerve biopsies from 25 neurological patients. The results of this study show that endoneurial vessels are normally permeable to all plasma proteins, though not to an equal degree. Permeability of the nerve blood vessels may be increased in pathological conditions. Proteins of molecular weight equal to or greater than 340,000 tend to accumulate at the site of the perineurium, indicating a slow removal from this structure. A marked accumulation of plasma proteins at the site of the perineurium was observed in hypertrophic neuropathy.

Adolescent↗
PubMed1975

The interaction of Concanavalin A and the surface coat of stratified squamous epithelium.

The interaction of Concanavalin A (Con A) and the surface membranes of the epithelial cells of human oral mucosa, epidermis and guinea-pig lip was studied. Two methods were used: fluorescent Con A and Con A in combination with horse radish peroxidase. With both methods the surface coat of epithelial cells was stained. The specificity of the staining methods could be demonstrated. The interaction between pemphigus antibodies and the surface membranes of epithelial cells could be blocked by Con A.

Animals↗
PubMed1975

Autoimmunity to sperm antigens in vasectomized men.

Sera from vasectomized men were tested for the presence of antibodies directed against sperm antigens. A high percentage (about 55%) of the vasectomized men developed agglutinating antibodies. A lower percentage (22%) also developed low titres of antibodies to human protamine, as detected in the indirect IFT on swollen sperm heads and 22% developed cytotoxic antibodies. A correlation was found between the presence of anti-protamine antibodies and the presence of agglutinating and of cytotoxic antibodies. This correlation, and also the fact that they developed after vasectomy, indicates that the formation of antibodies against human protamine is a result of an autoimmune response to spermatozoa. The indirect IFT was also performed on 'normal' unswollen spermatozoa. All the sera were positive at least on one of the sperm antigens located in the acrosome, equator, or post-nuclear region, but no increase nor decrease in titre was found after vasectomy.

Acrosome↗