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J M Vera-Román

Publications and source records attributed to J M Vera-Román.

At least 19 recordsLinked to original sources
PubMed2005

Cerebral solitary Langerhans cell histiocytosis: report of two cases and review of the literature.

Cerebral solitary Langerhans cell histiocytosis (LCH) is a very uncommon condition. We describe two new cases: a 30-year-old man with seizures and a tumour in the left frontal lobe, which was composed of a polymorphic infiltrate with a predominance of histiocytes and eosinophils; and a 65-year-old man with headaches and dysarthria, with a left parietal tumour, which showed a diffuse proliferation of histiocytic cells and areas of necrosis. In both cases, the histiocytes were strongly positive for S-100 and CD1a, and Birbeck's granules were demonstrated by electron microscopy in the first case. Both patients underwent a complete excision of their lesions. The second patient received additional postoperative radiotherapy. They were asymptomatic after 26 and 27 months, respectively. It seems that cerebral solitary LCH is a clinicopathological entity with a good outcome. Only 15 cases of this rare process have been previously reported in the English literature.

Adult↗
PubMed2004

Intraorbital arteriovenous malformation: case report.

An intraorbital arteriovenous malformation became symptomatic without exophthalmos but with chemosis and bruit of the left eye. The patient underwent only surgical treatment. The orbital rim was removed through a fronto-orbital approach. The chemosis was corrected and postoperative magnetic resonance imaging and angiography confirmed complete removal of the malformation. Histopathological examination disclosed an arteriovenous malformation in the extrabulbar fatty tissue without invasion of the extraocular muscles or optic nerve. The differences between various types of intraorbital malformations are discussed.

Case Reports↗
PubMed2001

[Prognosis value of p53 gene and cellular proliferation factors in malignant supratentorial gliomas].

OBJECT: The aim of this study was to investigate prognosis value of p53 oncosuppresor gene and labeling index by MIB-1 and PCNA monoclonal antibodies in malignant gliomas. METHODS AND RESULTS: We operated 60 patient with malignant glioma between July 1994 and August 1998. Forty-five cases had the histopathological diagnosis of Glioblastoma Multiforme and fifteen cases of anaplastic astrocytoma or olygoastrocytoma. Initially we compare MIB-1/PCNA labeling index in eighteen cases. Patients < 40 years old, short period of symptoms preoperatively, only one cerebral lobe localization, total surgical exeresis, Karnofsky index > 70 postoperatively, low labeling index (MIB < 8.6%), forward radiotherapy treatment and surgical re-operation, were identified like favourable outcome factors in the uninvariable analysis. However to the multivariable analysis, only had outcome significance: patients < 40 years old, low labeling index, Karnofsky index > 70 postoperatively and surgical reoperation. CONCLUSIONS: On the basis of the results of current analysis, moreover classical factors associated with better outcome, low labeling index to Glioblastoma Multiforme have been noted in patients with longer survival, and must be included to conventional histopathological studies.

Adult↗
PubMed1992

[Villous adenoma of urinary bladder. Report of a new case].

We report on an 80-year-old female patient with a villous polyp of the bladder. We believe this lesion may correspond to an intermediate stage in the well known sequence of injury-metaplasia-dysplasia-carcinoma of the large intestine. Intestinal metaplasia in the bladder is a potentially malignant lesion. If villous adenomas are diagnosed early, before malignant transformation, simple excision can achieve cure.

Adenoma↗
PubMed1991

[Nonamyloid light-chain deposit disease. A report of 2 cases].

Two cases of non-amyloid light chain deposit disease (EDCL) which were diagnosed by liver biopsy are presented, and the recent literature is reviewed. This disease is a dysproteinemia which shares numerous clinical and pathological features with amyloidosis. A commentary is made on the differential diagnosis between both diseases. This disease must be suspected when the conventional histochemical and immunohistochemical stains for amyloid are negative. Immunohistochemical assays for kappa and lambda chains should then be performed.

Adult↗
PubMed1989

[Anaplastic tumor of the bladder with neurosecretory granules and benign courses].

We report on a 59-year-old female patient with a bladder tumor that was initially classified as anaplastic (undifferentiated) tumor. Posteriorly, electron microscopic and immunohistochemical analyses of the specimen revealed a neuroendocrine tumor distinct from a paraganglioma. The origin and prognosis of bladder carcinoids and small cell undifferentiated carcinomas are discussed. The authors indicate that the level of bladder wall infiltration is the most important prognostic parameter in these type of tumors.

Carcinoma↗