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Biomedical subjects

J M Vich

Publications and source records attributed to J M Vich.

At least 19 recordsLinked to original sources
PubMed1991

Dimethyl sulfoxide inhibits human immunodeficiency virus production in vitro.

LDV/7, H9, and MOLT-4, three cell lines infectible by human immunodeficiency virus were incubated with dimethyl sulfoxide, an inducer of cell differentiation. It was shown that this is a powerful inhibitor of viral production, but its effect is transient: viral production resumes when the compound is removed from the culture medium. It does not inactivate the virus, and it fails to prevent viral infection or to inhibit expression of p24 on the surface of the infected cells.

Cell Line↗
PubMed1988

Soluble extracts from a lymphoblastoid cell line modulate simian immunodeficiency syndrome (SAIDS) evolution.

Nineteen Macaca fascicularis monkeys were injected with SIV. They were subsequently divided into 5 groups. Four groups of 4 animals were injected with dialysable extracts (DLE) from a lymphoblastoid cell line which had been previously induced with DLE obtained either from the total lymphocyte population, or from the CD4 or CD8 subpopulations of mice immunized with SIV virus. The other three animals which constituted the control group received saline injections. The animals were kept under observation for a 108-day period, and the values of several biological parameters were compared in a multivariant statistical analysis. On the 108th day, the control group was significantly different from the other groups in the multivariant analysis. Furthermore, the CD4/CD8 ratio and the platelets and CD4 cell counts varied significantly between the groups in the univariant analysis. It is thus surmised that DLE obtained from CD8 cells or the total lymphocyte population of immunized animals may exert a modulating effect on the evolution of SAIDS.

Adjuvants, Immunologic↗
PubMed1988

[The regulatory role of silicon in cell division].

Several reports have suggested that silicon has an activating effect on cell proliferation. In order to test this hypothesis, both peripheral human lymphocytes and LDV/7 lymphoblast cells were cultured in the presence of a compound composed of monomethylsilanetriol (silanol), a soluble organic form of silicon, and serine. This molecule stimulates peripheral lymphocyte proliferation at an optimal concentration of 10 mg of silicon per liter of culture medium; in identical conditions, it inhibits the growth of lymphoblastoïd cells (p less than 0.001). Silanol-serine also inhibits the growth of PHA stimulated lymphocytes. The effect of silicon on cell growth has a negative correlation (p less than 0.001) with the mitotic activity of cultured cells: the more intense the latter, the stronger is the inhibitory effect of silanol-serine. This would suggest a regulatory role of this compound on the cell cycle.

Cell Division↗
PubMed1986

Specific transfer factor protects mice against lethal challenge with herpes simplex virus.

Bovine transfer factor (TFd) specific to herpes simplex virus (HSV)1 or to HSV2 was prepared by immunizing calves with the corresponding virus. The TFd preparations were then injected into Swiss mice in an attempt to protect them against a subsequent lethal challenge with HSV1 or HSV2 virus. It was thus shown that injection of anti-HSV TFd protects the mice against the corresponding HSV virus, whereas the injection of a nonspecific TFd (anti-CMV) fails to protect against a challenge with HSV1. Furthermore, a dose-response effect was observed, since potent TFd preparations were ineffective when they were used at one-fifth of the original concentration. It seems, therefore, that animal models may be used to assay the potency of TFd preparations specific for herpes viruses.

Animals↗
PubMed1984

[Treatment of herpes infections with transfer factor].

Twelve patients suffering from recurrent herpetic infections resistant to several current therapies were treated for a 3 to 10 months period with a bovine transfer factor specific to Herpes simplex virus of type 1 and 2. The results obtained showed that this treatment was capable of dramatically reducing the intensity, duration and frequency of the relapses. This preliminary clinical trial suggests that specific transfer factor administered orally could be an effective treatment of herpes infections.

Adult↗
PubMed1983

An in vitro study of lymphocytes in patients with atopic dermatitis.

The authors studied the T- and B-lymphocyte sub-populations, the stimulation of the lymphocytes with phytohaemagglutinin and pokeweed mitogen, the non-specific T suppressor activity and the amounts of serum IgE in a group of thirty-four patients with atopic dermatitis. Comparison with a group of 100 healthy controls revealed a diminution in the T sub-population, an increase in the B sub-population, no change in the response index to stimulation with phytohaemagglutinin or pokeweed mitogen, a diminished T-suppressor activity and an increase in the level of serum IgE.

Adult↗
PubMed1982

T-lymphocytes and nonspecific T-suppressor activity in patients with extrinsic asthma.

The authors studied the distribution of T-lymphocytes (T-Et and T-Ea) and the nonspecific T-suppressor activity induced by ConA in a group of 104 patients (adults and children) with extrinsic asthma. Comparison with the control group revealed a diminution in the T-Et population (p less than 0.01), no significant change in the T-Ea population and a diminished nonspecific T-suppressor activity (p less than 0.001). The possible role of the T functional deficiency in the development of allergic diathesis is discussed.

Adolescent↗
PubMed1981

Altered cellular immunity and suppressor cell activity in patients with primary retinitis pigmentosa.

A group of 54 patients with primary retinitis pigmentosa were studied and the following findings are described: response of lymphocytes to stimulation by phytohaemagglutinin (PHA); response of lymphocytes to stimulation by xenogenic retinal extract; distribution of T and T-active lymphoid populations; total suppressor activity induced by concanavalin-A (con-A). The results obtained showed a reduction in the response to PHA (p less than 0.05), a positive response of 26/45 (p less than 0.001) to stimulation by retinal extract, a reduction in the T and T-active lymphoid populations (p less than 0.01), (p less than 0.01), and a diminished total suppressor activity induced by con-A (p less than 0.01). This alterations of immune cellular responses and the diminished suppressor activity in the group of patients, in comparison with a control group of healthy subjects, seems to indicate the existence of an immune process of disregulation (autoimmunity?) in the pathology of primary retinitis pigmentosa.

Adult↗
PubMed1980

In vitro stimulation of lymphocytes in patients with chronic urticaria induced by additives and food.

We studied the stimulation of lymphocytes in 258 patients with urticaria and/or angioedema using a series of food extracts and additives. Of this group, 238 revealed a positive response index (RI). There was a positive RI to additives in 18.4% of the cases, to food extracts in 35.2% and to both extracts and additives in 46.6% of the cases. A positive RI to both aspirin and tartrazine was revealed in 25% and to all the additives tested in 11% of the cases. Diets from which food extracts and additives were excluded achieved total remission in 159 (61.1%), partial remission in fifty-seven cases (22%) and no remission in forty-two (16.2).

Angioedema↗
PubMed1980

In vitro response of lymphocytes in patients with allergic tension-fatigue syndrome.

The authors studied the stimulation of lymphocytes in 44 patients with histories of allergic tension-fatigue syndrome using a series of food extracts and additives. Of a total of 44 patients studied, 42 produced a positive response (RI), 18.1% produced a positive response to additives, 40.9% to food and 36.6% to both. The elimination diets prescribed in accordance with the in vitro results obtained produced a total remission of the tension-fatigue syndrome in 38 patients (86.3%), partial remission in two (4.5%) and no change in four (9.0%).

Child↗