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Biomedical subjects

J M Vogel

Publications and source records attributed to J M Vogel.

At least 55 records · Page 3Linked to original sources
PubMed1987

Selection of the optimal skeletal site for fracture risk prediction.

Commonly known risk factors have been shown to correlate with mean bone mass in populations, but none of these risk factors, either alone or in combination, have been shown to be predictive of future fracture risk in an individual. In order to evaluate the predictive power of bone mineral measurements at various sites, bone mineral content (BMC) has been measured at four skeletal sites and compared to subsequent fracture incidence at all skeletal locations, including spine and appendicular sites. Os calcis BMC has the most consistent monotonic relationship to unadjusted fracture incidence rates; os calcis BMC also has the strongest (p = 0.009) relation to levels of relative risk, after adjustment for age, height, and weight. Based on actual ability to predict fracture risk prospectively, along with such secondary criteria as cost, ease of performance, precision, and radiation exposure, the os calcis appears to be an optimal BMC measurement site for routine screening of perimenopausal women.

Adult↗
PubMed1986

Promoting low-fat entree choices in a public cafeteria.

Reductions in dietary fat have been recommended in the prevention of coronary heart disease. Because entrees contribute substantially to total meal fat content, we evaluated a cafeteria-based intervention for increasing the purchase rate of low-fat entrees (M = 6.83 g) relative to nonlow-fat entrees (M = 25.59 g). The intervention included a poster listing the benefits of a LF diet and the daily LF entrees (i.e., broiled or baked chicken and fish dishes). During 6 days per phase, food selections (N = 3,264) were monitored by trained observers. The intervention, which cost $80.00, produced significant increases (i.e., from 20% to 35%) in the purchase rate of LF entrees.

Aged↗
PubMed1986

Differential effects of thiazide and estrogen upon bone mineral content and fracture prevalence.

Individual and combined effects of thiazides and estrogens upon bone mineral content at four sites (proximal radius, distal radius, os calcis, lumbar spine) and fracture prevalence were assessed retrospectively in 993 postmenopausal women. Compared with untreated women, use of thiazide alone was associated with significantly higher bone mineral content (P less than or equal to .01); nonspine fracture prevalence in this group was reduced by one-half (P = .07). Estrogen alone also was associated with significantly higher bone mineral content (P less than or equal to .0001); nonspine fracture prevalence was reduced by almost one-half (P = .07). The users of both estrogen and thiazide had the highest bone mineral content levels, which were significantly different than the thiazide-only group at four bone sites (P less than or equal to .001), and the estrogen-only group for three bone sites (P less than or equal to .05). Nonspine fracture prevalence for the users of both drugs was 17% that of the untreated group (P = .02). The relationships with spine fracture prevalence were less consistent; however, estrogen users appeared to have a lower spine fracture prevalence rate and higher spinal bone mineral content than thiazide users. These findings suggest a potential role for thiazides in the prevention of osteoporosis.

Adult↗
PubMed1985

Prediction of postmenopausal fracture risk with use of bone mineral measurements.

In a study of 1098 women (mean age, 63.3 years) nonspine fracture incidence and prevalence rates and spine fracture prevalence rates were compared by quintile of bone mineral content at the proximal radius, distal radius, os calcis, and lumbar spine. The risk of fracture associated with varying bone mineral content levels was explored with use of estimated odds ratios. Risk of fracture is significantly increased with diminishing quintiles of bone mineral content. Subjects in the lowest quintile of os calcis bone mineral content have a nonspine fracture risk 10 times greater than subjects in the highest bone mineral content quintile. The os calcis bone mineral content measurement is the best predictor of nonspine fracture risk and is also the best overall indicator of spine fracture risk. Therefore measurement of os calcis bone mineral content may be useful for routine risk evaluation of perimenopausal women. The ability to predict individual risk should allow for more rational preventive regimens.

Adult↗
PubMed1985

Histocompatibility antigens on murine tumors.

Recent advances in tumor immunology suggest that the expression of the histocompatibility antigens, encoded by the major histocompatibility complex, is important in controlling the metastatic growth of certain murine tumors. The anomalous expression of histocompatibility antigens in many neoplasms appears to be associated with the ability of these cells to evade the immune system and progress to metastasis. This review examines some of the underlying molecular and immunobiological interactions that might determine the metastatic outcome of cellular transformation.

AKR murine leukemia virus↗
PubMed1985

The relationship between diet and bone mineral content of multiple skeletal sites in elderly Japanese-American men and women living in Hawaii.

The relationship of dietary intake of nutrients assessed by 24-h recalls and supplementary intake of selected minerals and vitamins to the bone mineral content (BMC) of the radius, ulna, and os calcis measured by the photon absorption technique was cross-sectionally studied in a sample of elderly Japanese residents (1208 men and 912 women) in Hawaii. Dietary intakes of milk, calcium, and vitamin D were significantly and positively associated with BMC in both sexes after adjusting for age, weight, height, strenuous exercise (men), history of nonviolent fracture, thiazide use, and estrogen use (women). However, independent contributions of milk or nutrients to BMC were only modest as compared with those of major confounders. No consistent result was obtained concerning the effects of supplementary minerals and vitamins upon BMC.

Adult↗
PubMed1984

Bone mineral measurements among middle-aged and elderly Japanese residents in Hawaii.

Cross-sectional data of bone mineral content measured at five skeletal sites (distal radius and ulna, proximal radius and ulna, and os calcis) with single photon absorptiometry were obtained from a population of Japanese-Americans living in Hawaii, comprising 1368 men (aged 61-81 years) and 1098 women (aged 43-80 years). Age-specific mean values of bone mineral content for all skeletal sites were much greater for men than for women and decreased steadily with advancing age in both sexes. The decrease in bone mineral content with age across a 15-year age range was two to four times (depending on skeletal site) greater for women than for men. In multiple regression analyses, age, weight, and postmenopausal estrogen use were potent determinants of bone mineral content for all skeletal sites. Weight was more strongly related to bone mineral content of the os calcis than age in both sexes. Height was significantly related only to the forearm bones. Strenuous exercise was significantly related to bone mineral content of the os calcis and the distal ulna only in men. When compared with US Caucasians of comparable sex and age, the Japanese in Hawaii have lower bone mineral content of the radius. This may partly be explained by the difference in body size. Significant correlations were found between bone mineral content of appendicular bones and radiographically determined vertebral osteoporosis.

Adult↗
PubMed1983

Thiazide effect on the mineral content of bone.

The thiazide diuretics are known to cause calcium retention. In order to study the effect of thiazides on bone mineralization, we have measured the mineral content of bone at five sites (the distal radius, the distal ulna, the proximal radius, the proximal ulna, and the os calcis) in 1368 men with a mean age of 68 years, including 323 who were taking thiazides for hypertension. The results were adjusted for age and body-mass index. Thiazide users had significantly more bone mineral content at all five sites than did non-users. Untreated hypertensive patients and persons without hypertension had comparable bone mineral content, indicating that the higher mineral content found among thiazide users is related to the drug and not to the underlying hypertension. These findings suggest the possibility of a preventive or therapeutic role for thiazides in osteoporosis.

Aged↗
PubMed1980

Renal clearance and extraction parameters of ortho-iodohippurate (I-123) compared with OIH(I-131) and PAH.

o-[131I] iodohippurate [OIH(I-131)] has been used for many years in the estimation of effective renal plasma flow. This compound suffers from low photon yield and poor images when the quantity used is limited to stay within a reasonable radiation dose. To test the validity of substituting I-123 for I-131, a series of experiments was performed in a surgically prepared dog model. The extraction ratios and clearance values OIH(I-123) prepared from radionuclidically pure I-123 were compared with those of commercial OIH(I-131) and PAH. The extraction ratios for OIH(I-123) and OIH(I-131) were 0.65 and 0.67, representing 0.86 and 0.88 that of PAH, respectively. The clearance values (cc/min/kg) for the I123 and I-123) can be used to estimate effective renal plasma flow; moreover, because of the high yield within an acceptable radiation dose range, images of good quality can be produced.

Aminohippuric Acids↗
PubMed1979

The influence of verbal descriptions versus orientation codes on kindergartners' memory for the orientation of pictures.

Kindergarten children who viewed a series of 10 line drawings of objects subsequently showed little ability to distinguish between these pictures and their left-right mirror images. However, the children's memory for orientation improved substantially when children were induced to (a) give detailed verbal descriptions of the pictures, or (b) specify a difference between characteristics on the child's side versus the experimenter's side of each picture, or (c) both. The 3 induced strategies were equally effective. On a posttest given approximately a week later, the children did not maintain use of any of these effective strategies.

Attention↗
PubMed1978

Renovascular hypertension as a complication of umbilical arterial catheterization.

Renovascular hypertension (RVH) in the neonatal period is frequently associated with thromboembolic complications of umbilical artery catheterization. Seven newborn infants with RVH were studied by angiography and/or radionuclide examination. Aortography and, in one case, selective angiography showed variable degrees of renal artery occlusion or attenuation. Thromboembolic defects were frequently present in other vessels. Radionuclide flow studies, renograms, and computer analysis of data (ADAC) demonstrated defects in renal function, indicative of renal ischemia. There was a high degree of correlation between angiographic and radionuclide studies. Successful medical management suggests a more conservative alternative to nephrectomy in the hypertensive newborn.

Angiography↗