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Biomedical subjects

J M Weller

Publications and source records attributed to J M Weller.

At least 37 records · Page 2Linked to original sources
PubMed1977

Intrarenal hemodynamics and ureteral pressure during ureteral obstruction.

Renal blood flow was measured in bilateral ureteral obstruction (BUO) and unilateral ureteral (UUO) obstruction. Renal blood flow of BUO and UUO rats before release of 24-hr obstruction was approximately 69 per cent and 77 per cent of control values, respectively. No redistribution of intrarenal blood flow was noted in UUO and BUO rats. Prerelease ureteral pressure of BUO rats (27.6 +/- 1.60 mm Hg) was significantly higher than that of UUO rats (14.4 +/- 1.30 mm Hg, P less than 0.001). Although the blood urea nitrogen of UUO rats with urine reinfusion was similar to that of BUO rats, the ureteral pressure was 14.8 +/- 1.93 mm Hg. Therefore, the higher ureteral pressure of BUO rats is not due to elevation of blood urea nitrogen. It is concluded that decreased renal blood flow during obstruction and high ureteral pressure may result in more severe tubular damage in BUO than in UUO. The decreased renal perfusion is probably due to changes in intrarenal vascular tone rather than due to intersitial pressure.

Animals↗
PubMed1976

Intrarenal hemodynamics in acute myohemoglobinuric renal failure.

Renal blood flow (RBF) and its distribution were measured in acute renal failure induced by glycerol injection to water-drinking rats and to rats chronically loaded with NaCl solution. Mean RBF and intracortical blood flow distribution of both water-drinking and saline-loaded rats at 24 h after glycerol injection were not different from those of control rats. Although chronic saline loading blunted the impairment of renal function caused by glycerol as evidenced by serum creatinine values, no differences in renal hemodynamics were noted. This suggests that changes in glomerular arteriolar resistance or glomerular permeability might be of greater importance in the reduction of glomerular filtration rate than are alterations of blood flow.

Acute Kidney Injury↗
PubMed1976

The role of tubular necrosis in the pathophysiology of acute renal failure.

Renal tubular function was evaluated in vitro by kidney slice uptakes of p-aminohippurate (PAH) and tetraethylammonium (TEA) at 24 and 48 h in water-drinking rats and at 24 h in chronic saline-loaded rats after induction of acute tubular necrosis (ATN) by HgCl2 and glycerol injection. Significant correlations between decrease tubular uptake of PAH and TEA and elevated serum creatinine levels were noted in both models of ATN in water- and saline-drinking rats. However, with the same degree of impairment of PAH and TEA uptakes the creatinine was significantly lower in saline-loaded rats than in water-drinking rats in both forms of ATN. The correlation between impaired tubular function and elevated creatinine suggests that tubular damage and glomerular filtration reduction might be pathophysiologically related in ATN.

Acute Kidney Injury↗
PubMed1976

Derman necrosis due to thrombosis in severe secondary hyperparathyroidism.

Two patients had gangrenous dermal necrosis associated with chronic renal disease and secondary hyperparathyroidism. Thromobosed and heavily calcified small arteries were underlying the infarcted areas. One patient had severe hypotension secondary to hemorrhage, which immediately preceded the appearance of dermal lesions. Both patients had notably elevated serum parathyroid hormone and serum alkaline phosphatase levels, as well as severe hyperphosphatemia. Therapy with phosphate binders and calcium and vitamin D supplementation corrected the hyperphosphatemia and reduced serum alkaline phosphatase levels. One patient died; the other patient's dermal lesions healed completely. Localized thrombosis, rather than obliterative intimal proliferation, represents a unique cause of dermal necrosis in this condition.

Arteriosclerosis↗
PubMed1975

Measurement of renal blood flow in the rat.

The radioactive microsphere technique is a simple method for measurement of RBF and intrarenal blood flow distribution in the rat that does not require surgical manipulation of the kidney or general anesthesia. The results are reproducible and compatible with other established techniques.

Animals↗