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J M Wells

Publications and source records attributed to J M Wells.

96 records · Page 6Linked to original sources
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Hybrid formation between African trypanosomes during cyclical transmission.

Trypanosomes of the species Trypanosoma brucei reproduce primarily by binary fission, but the frequency of enzyme electrophoretic variants in natural populations of T. brucei has provided indirect evidence for the existence of a sexual cycle. These studies, coupled with studies of restriction fragment length polymorphisms of genes encoding glycolytic enzymes, have also provided evidence for T. brucei being diploid. Here we report direct evidence of gene exchange between two different clones of trypanosomes after mixed infection and full cyclical development in the tsetse fly vector.

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An introduction to selected elements of research.

The purpose of this paper, the first in a two-part series, is to provide an introduction to selected elements of research for the practising pharmacist. It is not intended to provide the reader with all the tools necessary to plan, conduct and report a research study. One paper cannot achieve this since entire books have been devoted to single components of research. Through the examination and discussion of the structure of a research report as presented in this paper, the reader should derive a basic understanding of selected aspects of research. A subsequent paper will present an approach to evaluating reports of research studies. The background provided by both papers should make it possible for pharmacists to review more objectively the increasing number of journal articles reporting research studies. Readers should also gain an appreciation of the complexity of the research process and the time required to prepare a paper acceptable for publication. They will not be in a position to evaluate all the details in the research report.

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Future directions in the analysis of gene expression in Alzheimer disease.

This review briefly explores future directions for gene expression research in Alzheimer disease (AD). Two complementary techniques, differential display and gene expression arrays, allow researchers to identify differentially expressed genes. These techniques promote a systematic examination of gene expression. In conjunction with a technique that allows the isolation of mRNA from individual cells, differential display and gene expression array technology can be used to examine AD-induced changes in gene expression patterns in individual cells. This area of research should elucidate information that will provide a greater understanding of the pathological processes in AD and aid in the development of therapeutic agents.

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