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Biomedical subjects

J M Yee

Publications and source records attributed to J M Yee.

9 recordsLinked to original sources
PubMed1998

Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve.

Vigabatrin (gamma-vinyl GABA) is an antiepileptic drug and blocks GABA transaminase activity resulting in elevations in cellular GABA levels in the brain. Nipecotic acid (NPA) promotes release of GABA from neonatal optic nerve astrocytes, resulting in a bicuculline-sensitive depolarization of the optic nerve axons. The NPA-induced depolarization of vigabatrin-treated rats (100 mg/kg, i.p.) more than doubled, suggesting an elevation in free GABA levels; the GABA transporter inhibitor, NO-711 reduced the depolarization. These results are consistent with the known ability of vigabatrin to block the GABA degradation enzyme GABA-transaminase, suggesting that vigabatrin elevates astrocytic GABA levels, thereby favoring greater release of GABA through the GABA transporter.

Animals↗
PubMed1989

Abdominal sonography in AIDS. A review.

Sonographic examination of the abdomen was performed in 155 patients with clinical diagnosis of AIDS. Approximately one half of the patients had hyperechoic (fatty) liver and splenomegaly. About one third of the patients had lymphadenopathy and hyperechoic kidneys. Intravenous drug abusers were more likely to have renal parenchymal changes, whereas patients with sexually transmitted AIDS have a greater incidence of splenomegaly. Lymphadenopathy is the most consistent finding that would question the immune competency of a patient in the appropriate clinical setting. The usefulness of sonography lies in the detection or exclusion of potentially treatable complications in AIDS.

Abdomen↗
PubMed1977

Pericardial drainage operations in the management of uremic pericardial effusion.

Because of frequent failures in nonoperative therapy, we have adopted early surgical drainage of the pericardium in the management of uremic pericardial effusion. This series presents the longest follow-up period of any group of patients with uremic pericardial effusion treated by surgical drainage. There have been no intraoperative deaths and no recurrences. The total hospital mortality rate was 8.3 per cent and the late mortality rate over a 72 month period was 25 per cent. Internal pericardiostomy drainage is a simple yet effective surgical solution to the life-threatening problem of uremic pericardial effusion.

Drainage↗