Preservation of the olfactory tract in bifrontal craniotomy for various lesions of the anterior cranial fossa.
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Biomedical subjects
Publications and source records attributed to J M van Dijk.
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Many surgical techniques are employed for access to midline lesions of the anterior and middle fossa. A convenient one is the midfrontobasal approach. For various indications this surgical procedure was performed in 105 patients. Its benefits are outlined and a method for dealing with the two main drawbacks, postoperative loss of the sense of smell and the presumed risk of infection related to the inevitable opening of the frontal sinus, are described. In 83% of the cases the authors were able to anatomically retain the olfactory nerves, with preservation of the sense of smell in at least 65% of them. The frontal sinus was opened in 76% of the cases. The incidence of infection in the simple and quick integral reconstruction appeared 1%, equal to the rate of infection in the classical reduction of the frontal sinus by a periosteal flap.
Hypercalcemia is an extremely rare complication of prostatic carcinoma. It occurs mainly in patients with disseminated osseous metastases and may be corrected by bilateral orchiectomy or hormonal manipulation. Humoral factors may be involved in its pathogenesis. Its occurrence is an ominous prognostic sign. We report a case of hypercalcemia that developed in a man suffering from adenocarcinoma of the prostate and who had undergone bilateral orchiectomy. Mental confusion, anorexia, and abdominal pains were the presenting symptoms. The hypercalcemia was refractory to treatment with fluids, furosemide, steroids, and calcitonin, and responded only to mithramycin. Cessation of this medication resulted in a prompt recurrence of the hypercalcemia.
A comparison was made of the presentation of tuberculosis (TB) between a young immigrant population from Ethiopia (mean age 21.2 +/- 16 yr) and an elderly Israeli group (mean age 71.4 +/- 10 yr). Prominent differences were the complaint of weakness among the elderly who also had more anorexia and weight loss. The time between the onset of complaints and the diagnosis was 2 months in the elderly and 3.5 wk in the younger group (p < 0.05). Four of the elderly died, 2 from causes related to TB; none of the younger patients died. The insidious and non-specific symptoms in the elderly tend to cause a delay in the diagnosis unless there is a high index of suspicion.
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We describe a patient with primary amyloidosis in whom multiple osteolytic lesions caused by amyloid bone tumours developed, and review the clinical features of the 18 cases with primary amyloidosis in whom destructive bone lesions have been reported. In contrast to amyloidosis associated with multiple myeloma, destructive lesions in the primary disease are mainly located to long bones; joint involvement is common, and radionuclide bone scan shows pronounced uptake of 99mTc-PP by the destructive bone lesions. Despite the superficial similarity between the destructive bone lesions associated with primary amyloidosis and multiple myeloma, distinction between these entities on clinical grounds is possible and may be easily confirmed by direct aspiration of the osteolytic infiltrates.
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The preleukemic syndrome occurs mainly after middle age. We report 11 patients, aged 62 to 92 years, who presented with weakness, fatigue, malaise and pallor. Eight patients died; survival from the time of diagnosis was between 2 and 21 months. Two of them developed acute myelomonocytic leukemia. A third patient developed Philadelphia chromosome-negative chronic myeloid leukemia within 9 months. Serum unsaturated B12 binding capacity and transcobalamin I were elevated in this patient, preceding the transformation to chronic myeloid leukemia. Five other patients died from sepsis or pneumonia. All patients were anemic, and 10 were leukopenic. Bone marrow was hypocellular in 1 and hypercellular in 10 cases. Chromosomal studies were performed in five patients, with three showing abnormal findings: 47xx, trisomy 8 and a tetraploid karyotype 92xxyy5q-. No cytotoxic treatment should be given during the preleukemic phase until transformation to acute leukemia occurs. Since preleukemic patients are very susceptible to infections, early diagnosis of the condition is important, as is supportive care in the case of surgery.