The absorption of radioactive vitamin B12 in megaloblastic anaemia, with observations on the diagnostic value of the Schilling test.
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Biomedical subjects
Publications and source records attributed to J METZ.
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The importance of deficiency of the folic acid group of compounds (folates) in the pathogenesis of nutritional anaemias is receiving increasing recognition. There is evidence that the megaloblastic anaemias, due to either vitamin B(12) or folate deficiency, may be the cause of widespread morbidity in malnourished populations. It was therefore considered timely to review certain aspects of the role of folates in megaloblastic anaemia, with special reference to the dietary intake in relation to human requirements, and the recognition of folate deficiency in man.
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The validity of a simplified procedure for the direct estimation of both red cell and plasma volume, using (51)Cr-labelled erythrocytes and radioiodinated human serum albumin, has been examined. It is suggested that the procedure, involving three venepunctures only, will yield accurate measurements of both compartments.
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The absorption of (60)CoB(12) has been studied in a group of patients suffering from megaloblastic anaemia associated with pregnancy and in a control group. The mean urinary excretion of (60)CoB(12) in the patients with megaloblastic anaemia is not significantly different from that of the control group. Five of the 30 patients showed a value towards the lower limit of normal, but the serum vitamin B(12) content in this group was within the normal range. Malabsorption of vitamin B(12) does not appear to play a significant role in the pathogenesis of this form of megaloblastic anaemia.
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