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Biomedical subjects

J Macía Martí

Publications and source records attributed to J Macía Martí.

6 recordsLinked to original sources
PubMed1988

[Epidural spread of neuroblastoma].

Epidural spread of neuroblastoma is a point of major concern, on account of implications it entails and differences in criteria regarding its therapeutic management. In this study records of all patients with neuroblastoma who had been followed up from 1966 to 1980, from whom only a thorough neurological examination and plain X-rays of spine had been obtained, were reviewed. Eleven cases of epidural invasion were identified out of 69 neuroblastomas at risk (16%). Between 1980 and 1982, 6 out of 11 patients with neuroblastoma considered likely to spread underwent myelography. This technique disclosed spinal involvement in 5. From 1982 to 1986, 23 new cases of neuroblastoma (14 at risk) have been studied by CT-scan or myelography, with the yield of 2 cases with epidural invasion (14%). Authors, based on the study of this series, set forth their current views with respect to diagnosis and treatment of such patients.

Child, Preschool↗
PubMed1987

[Non-Hodgkinś lymphoma in childhood, preliminary results of the LSA2 L2 protocol modified by high-dose methotrexate].

From january 1982 to january 1986 we treated 23 pediatric patients who had non Hodgkin's lymphoma, with a new therapeutic protocol. This protocol is based on the LSA2 L2, modified during the induction phase with high-dose methotrexate and increasing of intrathecal therapy. Nineteen patients (83%) were in stages III and IV and the 47.4% were in stage IV. The distribution according to histology was: 10 Burkitt's undifferentiated lymphomas; 2 non-Burkitt's undifferentiated lymphomas; 5 lymphoblastic lymphomas convoluted-cells; 5 lymphoblastic lymphoma non-convoluted cells and 1 indeterminate lymphoma. The follow-up oscillated between 6 months and 4 years. The total survival rate is 82.6% with a 100% survival in stages I, II and III and 63.5% in stage IV. The survival according histology is 91.7% for undifferentiated lymphomas and 70% for lymphoblastic lymphomas; the actuarial survival rates in the two groups at 30 months are 87% and 55% respectively (p greater than 0.10). We concluded that adding high-dose methotrexate to the LSA2 L2 protocol improve the survival rate in undifferentiated lymphomas and in a less extent in lymphoblastic lymphomas, without significant toxicity. This new protocol is mainly indicated in undifferentiated and indeterminate non-Hodgkin's lymphomas.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

[Partially differentiated cystic nephroblastoma].

Two new cases of cystic partially differentiated nephroblastoma, which were treated by nephrectomy, are reported. Their gross appearance is undistinguishable from a multilocular cyst, with the only difference being the presence of buds of blastema within the cystic septa. While cystic partially differentiated nephroblastoma as well as multilocular cyst have never been reported to be associated with local or metastatic recurrence and therefore their treatment consists of simple nephrectomy, the presence of blastema suggests a differentiates stage of Wilms' tumor, thus demanding a close surveillance of the patient.

Diagnosis, Differential↗