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J Madej

Publications and source records attributed to J Madej.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Significance of vascular changes in the colposcopic diagnosis of precancerous and early stages of cervical cancer].

Blood vessels are visible in an average of 80% of patients on whom colposcopy is performed. This percentage share increases if there are pathological changes. The following vascular types occur as characteristic criteria in cervical intraepithelial neoplasia (CIN) and in carcinoma, their classification being based on structural properties such as calibre, long and intercapillary spaces, shape and arrangement of the vessels, as well as their functional state: Abnormal vessels; pathological vessels of the 1st and 2nd degree; uncharacteristic vessels (also known as "troubled vessels"). The author discusses the architecture, adaptive vasodilation and formation of new vessels in connection with morphological changes in the epithelium. Their occurrence is evaluated statistically, and an inference is drawn from these studies on the efficiency of vascular diagnosis. The following conclusions are arrived at on the basis of the examined material: The abnormal vessel result from a proliferation of the abnormal or dysplastic epithelium. The pathological vessels of the 1st degree occur as maximum type of adaptive vascular change resulting in the course of carcinomatous proliferation. The pathological changes of the 2nd degree, on the other hand, become visible as new formations in invasively growing carcinomas only. There is a connection between the presence of pathological types of vessels and the carcinomatous degeneration of the epithelium and the invasive growth. Assessment of the vessels must be performed parallel to the assessment of the epithelium via acetic acid or lactic acid test. This facilitates colposcopic diagnosis of precarcinomic and early stages of cervical carcinoma and enables conclusions to be drawn on an invasive growth of the carcinoma.

Blood Vessels↗
PubMed1981

Serum lipoproteins, lipid peroxides and prostacyclin biosynthesis in patients with coronary heart disease.

Serum low-density lipoproteins (LDL) and high-density lipoproteins (HDL) were prepared by gradient ultracentrifugation and dialysis from 12 healthy subjects and 15 patients with coronary heart disease and hyperlipoproteinemia. In both lipoprotein fractions cholesterol and lipid peroxides were determined. The effect of these lipoproteins on spontaneous prostacyclin biosynthesis in rat aortic slices was studied. Serum lipoproteins were susceptible to peroxidation during the preparation procedure. LDL were more prone to peroxidation than HDL. Little lipid peroxides were formed in lipoproteins when calcium ions had been removed by EDTA, and when butylated hydroxytoluene (BHT) was present at all stages of their preparation. LDL when prepared without these precautions either from healthy subjects or from patients with coronary heart disease markedly suppressed prostacyclin generation by rat aortic slices. This inhibition was unrelated to LDL-cholesterol, but was due to LDL-lipid peroxides. Peroxide-low LDL prepared from most of the healthy subjects and patients with coronary heart disease and concomitant hyperlipoproteinemia, did not inhibit prostacyclin biosynthesis. However, in one quarter of the patients, LDL was inhibitory. Consequently, in some patients with coronary heart disease, there operate unknown mechanisms which are responsible for the inhibitory activity of LDL on prostacyclin generation.

Adult↗
PubMed1981

[Colposcopic differential diagnosis of portiopapillomatosis (author's transl)].

The guidelines for differential diagnosis of portiopapillomas were established on the basis of 21 cases. The term "papilloma" is exclusively confined to the changes occurring at the surface of the portio. Two colposcopic criteria of the typical portiopapilloma are defined. These are: 1. the specific surface structure and the reactivity to acid reagents, and 2. the specific vascular architectonics and its ability to react to cyclopeptid hormones. Hence, three architectonic types of papillae and 3 basic types of blood vessels are described. Basing on the guidelines it has become colposcopically possible to differentiate between a benign papillomatous growth and an exophytic carcinoma. The atypical papillomas are described in the concluding section of the article. These are characterized by anomalies of the surface and of the vessels. The epithelial layer of these papillomas often shows dysplastic or even carcinomatous proliferation.

Carcinoma↗
PubMed1981

[Cytological and colposcopic diagnosis of decidual ectopy of the cervix (author's transl)].

The cytological and colposcopic fundamentals for correct diagnosis have been compiled in this article on the basis of 86 cases with residual transformation of the cervix. Colposcopically, the decidual transformation of the portio was subdivided into 4 groups, and the colposcopic characteristics of ectopia decidualis were defined. For cytological clarification of decidual transformation of the cervix, two smears are required. The first, taken from the lateral vault of the vagina, enables an insight into the hormonal functioning of the vaginal mucosa. The second smear is prepared by scraping off the transformed tissue. The smear also contains cells from the lower stratum. These are the decidually transformed stroma cells. Evaluation of these preparations and final diagnosis should be effected by an experienced and skilled cytologist. Colposcopic-cytological examination can supply sufficient diagnostic material to eliminate the need for biopsy for the purpose of histological examination. This has been tested in 21 cases of decidual ectopy.

Colposcopy↗
PubMed1978

[Colposcopic picture of blood vessels in the early stages of cervix cancer].

A case of carcinoma in situ with the beginning of invasion is presented. In contradistinction to the changes characteristic of such cases, in this case branching vessels completely typical of a normal transformation zone were found. This suggests only adaptive vascular hypertrophy without vascular neoplasia, in spite of the cancerous changes in the epithelium in situ.

Carcinoma in Situ↗