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J Malmquist

Publications and source records attributed to J Malmquist.

65 records · Page 4Linked to original sources
PubMed1967

Studies on the mechanism of kinin formation in inflammation.

1. Injection of autologous plasma into the subcutaneous space leads to kinin formation in man. Kinin formation was also observed after similar injections of homologous plasma in the rat, dog and guinea-pig. The material withdrawn from the subcutaneous tissue following the injection of plasma was characterized as kinin by inhibition of its formation with trasylol, by inactivation with chymotrypsin and by its pharmacologic effects.2. Kinins were also demonstrated in subcutaneous tissue following injections of compound 48/80, a histamine liberator.3. A slightly acid pH greatly favours the accumulation of kinins in subcutis.4. Human plasma kallikrein was not activated in vitro by histamine, serotonin, nicotonic acid or endotoxin. Human polymorphonuclear leukocytes initiated the formation of kinins in plasma.5. It is suggested that in inflammation, ;primary mediators' such as histamine, do not activate plasma kallikrein directly, but rather increase vascular permeability, permitting plasma to enter the extravascular space where conditions for activation exist. Kinin accumulation is enhanced in inflammation where pH is slightly lowered.

Animals↗
PubMedDate not supplied

Physical fitness, insulin secretion, and glucose tolerance in healthy males and mild type-2 diabetes.

The nature of the relation between physical fitness and glucose homeostasis was evaluated in two studies: (A) a cross-sectional study on 108 middle-aged non-diabetic men; (B) a five-month training program involving nine males with non-insulin-dependent (type 2) diabetes. It was found that the level of physical fitness was positively related to glucose tolerance, and that this relation was largely independent of body weight and basal insulin secretion. Furthermore, the training program for the diabetics resulted in improved glucose tolerance without change in either body weight or glucose-induced insulin secretion. It is concluded that glucose balance is significantly influenced by the physical fitness level, which is likely to be an important element in the pathogenesis of type 2 diabetes as well as in the treatment of that disease.

Adult↗