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Biomedical subjects

J Margarit

Publications and source records attributed to J Margarit.

18 recordsLinked to original sources
PubMed1999

Long-term follow-up of nineteen cystic lymphangiomas treated with fibrin sealant.

BACKGROUND: Surgical exeresis is regarded as the first choice treatment for cystic lymphangioma. Surgery may be extremely complex, giving rise to complications. Several therapeutic methods have been described to avoid the complications derived from the conventional surgical approach. The idea of treating lymphangioma by means of suction and injection of fibrin sealant (Tissucol), is an alternative to surgery. METHODS: The authors present 19 cases of cystic lymphangioma, treated with fibrin sealant injected into the lesion, during the 1991 to 1997 period. Two of the patients had been treated surgically and experienced recurrence of the tumor previous to treatment. In the other 17 cases, puncture was the only therapy applied. One patient required 3 punctures, another 6 patients required 2 punctures, and only 1 of them, after 2 unsuccessful punctures, was treated with surgical resection. The rest of the 10 cases subsided after the first puncture. Follow-up ranged between 3 and 72 months, with a mean of 40 months. RESULTS: The ultrasonographic (US) follow-up showed a complete remission in 17 patients treated with puncture. One patient remained with a small intermittent tumor, the appearance of which is related to catarrhal processes, and another patient rejected further puncture after the second one. No complications appeared. CONCLUSION: These results support the fact that the puncture, aspiration, followed by injection of Tissucol, is a choice in the surgical treatment of cystic lymphangioma.

Child, Preschool↗
PubMed1998

[Urinary obstruction in fetal rabbits. An experimental model].

An original model of urethral ligation on 23 gestational-day fetal rabbits is described, that can be applied in studies of both urinary obstruction and oligohydramnios. The surgical technique is detailed and subsequent urinary obstruction is assessed, as well as the lung weight. In conclusion, this is an easy, mildly aggressive, inexpensive and fast model that can be used to investigate the pathophysiology of urinary obstruction and that of oligohydramnios.

Animals↗
PubMed1997

Congenital hemangiopericytoma: two cases of familiar presentation.

We report two cases of congenital hemangiopericytoma localized in the abdominal wall in the first patient and scalp in the second. The treatment of both cases consisted in the complete resection of the tumor mass. Four and two years later the patients remain asymptomatic. The special interest in this case report lies in the extremely low incidence of congenital hemangiopericytoma and that this is the first reference to affected siblings.

Diagnosis, Differential↗
PubMed1997

Screening for active toxoplasmosis in patients by DNA hybridization with the ABGTg7 probe in blood samples.

We report the potential use of a specific Toxoplasma gondii DNA probe (ABGTg7). We applied a dot blot hybridization assay to blood samples for the diagnosis of cerebral toxoplasmosis (CT), acute toxoplasmic lymphadenopathy (ATL), and disseminated toxoplasmosis in transplant recipients (TRs). We studied a total of 84 individuals: 38 patients and 46 controls. We found positive hybridization signals for 12 (66.7%) of 18 patients with confirmed CT, 9 (52.9%) of 17 patients with ATL, and 2 (66.7%) of 3 TRs. PCR assays were performed in parallel for patients with ATL, resulting in T. gondii DNA detection for 10 patients (58.8%). A comparative study between dot blot and PCR assays performed with the blood of mice that had been experimentally infected with tachyzoites gave similar results: 60 and 70% positive results, respectively. Finally, the sum of positive values obtained by both DNA tests (dot blot assay plus PCR) increased the rate of positivity for ATL patients to 76.4%. These results demonstrate that the T. gondii ABGTg7 repetitive DNA element is an additional useful resource for diagnosing Toxoplasma parasitemia in patients with CT and ATL and in TRs. Thus, our ABGTg7-based dot blot test may lead to an improvement in T. gondii detection methods in patients with acute toxoplasmosis.

Animals↗
PubMed1982

[Pharmacodynamics of alizapride (author's transl)].

Studies of alizapride (N[(allyl-1 pyrrolidinyl-2) methyl] méthoxy-2 azimido-4,5 benzamide hydrochlorate) in mice and rats demonstrated little toxicity, particularly after parenteral administration. Alizapride's main pharmacodynamic effects are on the central nervous system. It is very effective against emesis induced by apomorphine and dihydrogenated ergot alkaloids in dogs. In this respect it is three times more effective than metoclopramide. In contrast to neuroleptics, alizapride does not modify equilibrium reflexes in mice, nor does it reinforce hypnosis induced by barbiturates. Only minor central antidopaminergic effects were recorded, less marked than those seen with metoclopramide. In mice, alizapride has no anticonvulsant or analgesic effects. It has little action on the autonomic nervous system or on the cardiovascular system. Alizapride has no antihistaminic or parasympatholytic effect. In dogs, sympatholytic effects and hypotension are seen only after giving a much higher dose than that which is effective against apomorphine and dihydrogenated ergot alkaloids.

Animals↗
PubMed1978

[Endocrinological effects of substituted orthoveratramides].

The substituted orthoveratramides, derived from the orthopramides by the addition of a second methoxy radical at position 3 in the benzene ring, possess strong endocrinological effects. In particular the N[(allyl-1 pyrrolidinyl-2) methyl] dimethoxy-2-3 sulfamoyl-5 benzamide blocks oestrus in the Rat at doses considerably lower than sultopride and inhibits so-called "castration cell" formation in the pituitary.

Animals↗
PubMed1978

[Biological properties of 4-amino-5 alkyl-sulfone substituted orthoanisamides].

The 4-amino 5-alkyl-sulfone substituted orthoanisamides can be distinguished from their non-aminated homologues (sultopride) or sulfamoyl homologues (sulpride) mainly by the intensity of their anti-emetic effects with regard to apomorphine and their mode of action, either on hippocampic rhythms or on locomotor rhythms in the Cat.

Animals↗