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Biomedical subjects

J Markowski

Publications and source records attributed to J Markowski.

At least 19 recordsLinked to original sources
PubMed2000

[Histological and clinical analysis of mesenchymal malignant neoplasms (soft tissue sarcomas) of head and neck region in the data of I ENT Department of Silesian Medical Academy].

Between the years 19890-1998 in I ENT Department of Silesian Medical Academy were treated surgically 15 patients suffering from soft tissue sarcomas of head and neck region. Patomorphological examination showed: fibrosarcoma (4 cases), haemangioendothelioma malignum (2 cases), rhabdomyosarcoma (2 cases), schwannoma malignum (2 cases), fibrohistiocytoma malignum (2 cases), tumor mixtus mesenchymalis (1 case), haemangiopericytoma malignum (1 case), extrasceletal osteosarcoma (1 case). Sarcomas were localised in paranasal sinuses (7 cases), orbita (5 cases), parapharyngeal space (1 case), parotid gland (1 case) and bucca (1 case). All those patients were treated surgically and most of them were irradiated postoperatively. The authors have presented the diagnostic and methods of treatment of soft tissue sarcomas. According to our experience and data of the literature the method of choice in treatment soft tissue sarcomas should consist of surgery and radiation therapy postoperatively.

Adolescent↗
PubMed2000

[A contribution to the etiology of objective tinnitus: the case of arteriovenous fistula between the superficial artery and external jugular vein].

The authors have presented a very rare case of vascular anomaly in 51-years old female with an arteriovenous fistula between the frontal branch and parietal branch of superficial temporal artery and external jugular vein with simultaneously haemangioma cavernosum of temporal region. The clinical manifestation and the diagnosis of this anomaly are discussed with particular stress laid on the role of carotid arteriography which demonstrated the presence of this abnormal arterio-venous communication. Surgical treatment and its results are discussed also. The results of diagnostic and therapeutic procedures were compared with cases described in the literature.

Arteriovenous Fistula↗
PubMed2000

[A rare case of multiple neoplasms of parotid gland: adenolymphoma and squamous cell carcinoma].

The authors have presented a very rare case of multiple primary neoplasms of parotid gland: adenolymphoma and squamous cell carcinoma. Primary multiple neoplasms and multifocal neoplasms are a very complex problem and therefore have been a topic of many articles. The authors describe mechanism of origin, frequency of occurrence, possibilities of diagnostics. The main reason of these neoplasms origin are simultaneously exposure of the tissue to damaging factors and special tissue sensitivity.

Adenolymphoma↗
PubMed2000

[Antioxidant enzymes activity in patients suffering from laryngeal cancer].

The adequate activity of SOD, GPX and GR is a significant factor in oxidoreductation homeostasis maintaining. The attempt was made to estimate SOD, GPX, GR activity in full blood of 14 male patients suffering from laryngeal cancer (T2N0M0-T4N2M0). The studies were made before and in 8 and 16 week after the operation using RANDOX Company tests. The analysis of results proved that there were remarkable disorders of GR activity in comparison to a control group.

Antioxidants↗
PubMed1999

T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis.

Autoimmune inflammation secondary to myelin destruction may play an inhibitory role in restoration of nerve functions in spinal cord injury (SCI). In this study, we demonstrated that T cells recognizing myelin basic protein (MBP) occurred at a high precursor frequency in patients with SCI, which was compatible to that in patients with multiple sclerosis (MS), a disease of presumed autoimmune pathology. The findings suggest of hyperactivity of MBP-reactive T cells in patients with SCI. MBP-reactive T cell lines derived from patients with SCI exhibited a preferential recognition pattern toward the 81-99 and the 151-169 regions of MBP. There were functional differences in the epitope recognition and cytokine profile between two panels of MBP-reactive T cell lines derived from patients with SCI and patients with MS. The study provides new evidence important for further investigation of the role of the inflammatory component in SCI.

Adult↗
PubMed1999

Activity of glutathione transferase and reductase in tissues of bird cherry-oat aphid during its host-plant alternation.

Changes in activity of detoxifying enzymes, involved in metabolism of glutathione in bird cherry-oat aphid during its host alternation have been investigated. Glutathione transferase (GST) and glutathione reductase (GR) activity was found in homogenates from tissues of the bird cherry-oat aphid, Rhopalosiphum padi (L.). The highest activity of the enzymes was recorded in winged migrants that fly from bird cherry (Prunus padus L.), the winter host onto cereals a summer host. Before the migration an increase in activity of the glutathione transferase and glutathione reductase within tissues of winged migrants was observed. When the migrants started to feed on cereals, GST activity further increased and GR activity decreased. The significance of the R. padi glutathione transferase and reductase in detoxification of plant allelochemicals while the aphid host-plants alternation is discussed.

Animals↗
PubMed1999

[Primary orbital tumors treated surgically in ENT department of Silesian Medical Academy in Katowice].

Primary tumours of orbital cavity are a difficult diagnostic and therapeutic problem from a borderline of ophthalmology, laryngology and neurosurgery. Particular anatomical relations of orbital cavity surrounded by paranasal sinuses, cranial cavity cause that it has become an interdisciplinary region and the best method of therapy is multispecialistic surgical treatment ("team approach"). In this article the classification and general symptomatology of orbital cavity primary tumours were presented. 37 patients suffering from primary orbital tumours were treated surgically in the ENT Department of Silesian Medical Academy in Katowice. The patients were aged from 23 (woman with neurosarcoma) to 73 (man with melanoma). All patients were treated surgically: 15 of them by orbital exenteration, 10 by lateral orbitotomy m. Kronlein-Reese-Berk, and 12 by canthotomy. Special attention was paid to possible postoperative complications.

Academic Medical Centers↗
PubMed1999

[The assessment of lateral orbitotomy by Krönlein-Reese-Berke in surgical treatment of primary non-malignant orbital tumors].

AIM: The assessment of lateral orbitotomy by Krönlein-Reese-Berke was made to evaluate the possibility of radical removal of primary orbital tumors, function of visual system and cosmetic effect after lateral orbitotomy. MATERIAL AND METHODS: The authors analysed a group of 14 patients treated for primary non-malignant orbital tumors. They were treated in I ENT Clinic of Silesian Medical Academy in Katowice surgically by Krönlein-Reese-Berke lateral orbitotomy. A control examination (after 3 years) performed in all 14 patients did not show recurrence of tumor, the motility of the eye ball and visual function was normal, cosmetic effect was good. CONCLUSIONS: We suggest that in the cases of primary non-malignant tumors localised in the lateral part of the orbita, orbitotomy by Krönlein-Reese-Berke is the optimal surgical approach.

Female↗
PubMed1999

[Air conduction threshold values in expanded range of frequencies (250 Hz-18 kHz) in otologically normal persons as assessment of mobility hearing organ in presbycusis].

High-frequency hearing loss is most significant for the organ of hearing aging. Air conduction threshold measurements were taken in 4 groups (aged 31-40, 41-50, 51-60, 61-70 years) of otologically normal persons in expanded range of frequencies (250-18,000 Hz). The threshold of air conduction increase parallel to age and to pure tone frequency was stated.

Adult↗
PubMed1998

[A rare case of multiple primary malignant neoplasms of parotid gland: fibrosarcoma and squamous cell carcinoma].

Primary multiple malignant neoplasms and multifocal neoplasms are a very complex problem and therefore have been a topic of many articles. The mechanism of origin, frequency of occurrence, co-existence of neoplasms in functionally similar organs (uterus, mammary gland), heredity, a possibility of diagnostic and therapy are the most interesting aspects. Frequency of multiple primary malignant neoplasms occurrence is about 2-8% and still increases. Pathogenesis of multifocal and multiple neoplasms has rarely been a subject of articles. A simultaneous exposure of a tissue to damaging factors and special tissue sensitivity are the main reasons for neoplasms origin in this group. The authors present a rare case of parotid gland multiple neoplasm: fibrosarcoma and squamous cell carcinoma, as well as discuss the diagnostics, therapy, and prognosis of multiple neoplasms.

Antineoplastic Agents↗
PubMed1998

[Plastic tracheostomy tube of Luer's type].

The authors describe a plastic tracheostomy tube which has been accepted as the registered model No: PL 54620 Y1. The presented tube is applied in patients in I ENT Department of the Silesian Medical Academy in Katowice. The authors presented advantages of plastic tracheostomy tube.

Equipment Design↗
PubMed1996

Clinical assessment of spasticity in spinal cord injury: a multidimensional problem.

OBJECTIVE: To determine the relation between various components of spasticity evaluated clinically in persons with spinal cord injury (SCI). DESIGN: Case series evaluating spasticity using clinical scales commonly referenced in contemporary literature, including the Penn Spasm Frequency Scale, the Ashworth Scale, and standard scales of tendon taps, clonus, and plantar stimulation. SETTING. A Veterans Affairs Medical Center Spinal Cord Injury Center. PATIENTS. Eighty-five spinal cord injured individuals with varying degrees of spasticity. RESULTS: Correlations demonstrated weak relationships between Spasm Frequency Scale and self-report scales of interference with function (.407) and painful spasms (.312). No clinical examination score correlated with self-report scores greater than 0.4. Three clinical examination scores correlated modestly (> 0.5)-Ashworth score with patellar tendon taps (.553), ankle clonus with Achilles tendon tap (.663), and patellar tendon tap with adductor tendon tap (.512). Two other clinical scales correlated weakly (> 0.4)-Achilles tendon tap with patellar tendon tap (.417) and plantar reflex with adductor tendon taps (.423). CONCLUSIONS: Clinical scales currently used to evaluate spasticity in SCI correlate poorly with each other, suggesting that they each assess different aspects of spasticity. The use of any single scale is likely to underrepresent the magnitude and severity of spasticity in the SCI population. In the absence of agreement among these various scales and with the absence of an appropriate criterion standard for evaluation of spasticity, assessments of spasticity, whether clinical or neurophysiological in nature, should be comprehensive in scope.

Activities of Daily Living↗
PubMed1995

[Rare primary malignant orbital neoplasms treated surgically in the I Clinic of Otolaryngology of the Silesian Medical Academy in Katowice in the years 1992-1995].

14 patients suffering from primary orbital tumours were treated surgically in the Otolaryngological Department in Silesian Medical Academy in Katowice in the years 1992-1995. The patients were aged from 23 (woman with neurosarcoma) to 67 (woman with haemangioma). All patients were treated surgically: 8 of them by lateral orbitotomy m. Krönlein-Reese-Berk, 3 of them by orbital exenteration, and 3 of them by canthotomy. The author analysed 3 very rare cases of primary orbital malignant neoplasms: neurosarcoma, rhabdomyosarcoma and additionally I case with fibrosarcoma, osteosarcoma and chondrosarcoma simultaneously.

Adult↗
PubMed1994

Osteomyelitis associated with pressure sores.

BACKGROUND: Pressure sores may be associated with underlying osteomyelitis that is difficult to differentiate clinically from infection or colonization of adjacent soft tissue. Cultures of bone specimens are frequently contaminated with organisms residing in adjacent soft tissue. The three objectives of this cohort study were to (1) determine the accuracy of clinical evaluation for osteomyelitis; (2) evaluate the potential role of quantitative cultures of bone in differentiating osteomyelitis from soft-tissue infection or colonization; and (3) assess the impact of treating osteomyelitis on the outcome of pressure sores. METHODS: Thirty-six patients with pressure sores related to spinal cord injury or cerebrovascular accident underwent clinical evaluation for osteomyelitis, followed by percutaneous needle biopsy of bone. Routine semiquantitative and quantitative, aerobic and anaerobic cultures of bone specimens were performed. Pathologic examination of bone tissue was used as the standard criterion for diagnosing osteomyelitis. RESULTS: Six (17%) of 36 patients were diagnosed by pathologic examination as having osteomyelitis. The sensitivity and specificity of clinical evaluation were 33% and 60%, respectively. When positive, quantitative bone cultures yielded a similar number of bacterial isolates and a comparable range of bacterial concentration in patients with osteomyelitis vs those without osteomyelitis. Pressure sores healed in all six patients with osteomyelitis after appropriate therapy. CONCLUSIONS: Clinical evaluation for osteomyelitis is often inaccurate. Pathologic examination of bone tissue is required for definitive diagnosis of osteomyelitis. Quantitative bone cultures do not help differentiate osteomyelitis from infection or colonization of adjacent soft tissue. It is possible that treatment of osteomyelitis may improve the outcome of associated pressure sores.

Biopsy↗