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Biomedical subjects

J Masek

Publications and source records attributed to J Masek.

At least 19 recordsLinked to original sources
PubMed1992

[Experimental chronic phenylmercuric chloride poisoning in pigs].

Four gilts, sisters from one litter, aged 70 days and weighing 20-24 kg, were used for a trial. Two experimental gilts (P) were administered an experimental feed mixture containing phenylmercury chloride (40 mg/kg). Two control gilts (K) were fed the same mixture but without phenylmercury chloride. P gilts began to lag behind in their growth from day 60 of the experiment, they manifested nonphysiological postures (dog's sitting posture), paresis of hind limbs and uncoordinated movements. P gilts had cloudy, orange-brown urine from day 70 and from day 75 they began to suffer from diarrhoea. Mercury (Hg) contents in urine and blood serum of P gilts were irregularly variable: urine 0.58-2.15 mg/l, blood serum 0.02-0.37 mg/l. Hg content in excrements of P gilts fluctuated from 23 to 26 mg/kg. Vitamin A concentrations in blood serum and liver decreased in P gilts. Phenylmercury chloride feeding caused mutagenic changes in peripheral lymphocytes of P gilts (an increase in the number of aberrant cells from 2-3% to 8-9%) and reduced IgA, IgM and IgG immunoglobulin levels in blood serum. Pathological lesions were observed in the colon, kidneys and liver. None of the above-mentioned changes were observed in K gilts. Increased resistance to the negative effects of Hg was found in one experimental gilt. In comparison with K gilts, Hg concentrations in P gilts after 130 days of the experiment increased as follows: 427 times in kidneys, 333 times in liver, 106 times in guts, 71 times in pancreas, 53 times in ovaries, 50 times in muscles, 47 times in bristles and 16 times in the brain.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1992

[Ecotoxicologic relations on a large pig-fattening farm located in a lignite mining area and near and solid-fuel electical power plant].

Major contaminants identified in 1983-1984 on a pig fattening farm with an output of 60,000 pigs per annum, located in a lignite mining area and near a solid fuel power plant, were mercury, cadmium, lead, chromium and aflatoxin B1 (Tab. I, II, III, IV). Feed samples were collected from througs to assess the contamination load at feed uptake. Permissible concentrations of mercury, chromium, cadmium, aflatoxin B1, lead and atrazin in the feed were exceeded in 56, 50, 31, 19, 6 and 6% samples, respectively (Tab. I). Stable dust deposits, in which the contaminants concentrate, (Tab. I) proved to be a suitable material for assessing the type and level of environmental contamination. Permissible concentrations of mercury, cadmium and lead in porcine muscles were exceeded in 65, 51 and 24% samples, respectively (Tab. III). Corresponding values of mercury, cadmium, lead and aflatoxin B1 in the liver were 27, 27, 16 and 3%, respectively (Tab. III) and those of mercury, lead and chromium in kidneys 24, 22 and 5%, respectively (Tab. III). Rather surprisingly, elevated pancreatic concentrations of aflatoxin B1 were found (Tab. IV). Pigs fattened in the contaminated environment (i.e. fed contaminated feed mixtures, inspiring contaminated dust and absorbing percutaneously contaminants form dust deposits on the body surface) showed: 1) Impairment of the genetic apparatus (percentage of aberrant peripheral leucocytes elevated to 6.2%); 2) a certain degree of immunosuppression (concentrations of IgG, IgM and IgA reduced by 16.9, 45.1 and 45.0%, respectively); 3) higher feed consumption per 1 kg weight gain (4 kg) and lower average daily weight gain (0.57 kg); 4) increased incidence of health disorders (dermatitis in 25%, pancreatopathy in 13%, liver dystrophy in 8% and femoral fracture in 6% of the pigs). Unfortunately, the authors were not allowed to analyse ash and solid emissions from the power plant. Therefore the share of the emissions in the overall environmental contamination on the fattening farm could not be quantified. The personnel, working in the contaminated environment for a prolonged period, is endangered most of all by stable dust, being exposed to its mechanical, chemical, allergic and infectious effects (Tab. I). In addition to the chemical contaminants, 21 mould genera and species, six mite species and numerous saprophytic and some pathogenic bacteria were demonstrated in stable dust samples in our earlier experiments. Consumption of meat and organs from pigs fattened in a contaminated environment is associated with the risk of an increased uptake of various contaminants.(ABSTRACT TRUNCATED AT 400 WORDS)

Animal Husbandry↗
PubMed1990

[Reoperation for recurrent carcinoma of the large intestine and rectum].

Based on their own experience with reoperations of relapses of colorectal carcinoma the authors draw attention to the very poor results of these operations; even in case of early detection of a relapse of the tumour in the majority only a palliative operation could be performed and only in 10% patients a radical operation. Therefore the authors emphasize prevention of relapses.

Aged↗
PubMed1988

[Monitoring chromosome mutations in large-scale breeding operations].

The frequency of chromosomal aberrations and exchanges of sister chromatids (SCEs) in peripheral lymphocytes was studied in 65 pigs from five large breeding herds. Four groups comprised fattened pigs and the fifth group consisted of sows from a large multiplier breeding herd. During the investigation, the dust from the sites was analyzed for the presence of zinc, lead, cadmium, mercury, aflatoxin B1, PCB, DDT, and lindane. The average frequency of aberrant cells (AB.B) in the pigs of group I was 3.85 +/- 1.60%, in group II 2.10 +/- 1.52%, in group III 5.01 +/- 2.1%, in group IV 3.50 +/- 1.58%, and in group V 6.20 +/- 3.21%. The cytogenetic finding corresponded to the differences in the amount of foreign substances found in the dust on the premises where the animals of all groups were kept. The average frequency of the SCEs was 7.00 +/- 1.10 (I), 6.51 +/- 0.89 (II), 6.92 +/- 0.72 (III), 7.10 +/- 0.85 (IV) and 7.06 +/- 1.47 (V) per one cell. Statistically significant differences in the numbers of AB.B. were recorded between groups II and I, II and IV, I and III, IV and V (p less than 0.05) and between groups II and III, II and V (p less than 0.01). There was no statistically significant difference in the frequency of SCEs. The determination of the frequency of chromosomal aberrations can be used for the hygienic control of the degree of exposure of pigs to mutagens.

Animals↗
PubMed1987

[Foreign substances in the meat and organs of bulls and pigs fed with pastes made from household and food industry waste in addition to pastes made from poultry droppings].

The residues of antimicrobial substances, some chlorinated and organophosphate pesticides and chemical elements were studied in the meat and organs of a group of bulls fed food-waste paste for 240 days and a group of bulls fed the same paste with an addition of poultry waste. These residues were also studied in the tissues of pigs fed the food-waste paste for 135 and 151 days until slaughter. The feed ingredients were also examined during the feeding trials. Although some of the residues under study were found in the tissues of the test animals at increased amounts, their concentrations were diluted in the tissues in the majority of cases when the feed pastes were administered. All residue contents recorded in the tissues remained below the permissible limits as given in valid instructions and directives so that the products, i. e. meat and organs, could be deemed digestible on the basis of hygienic evaluation. Hence, from the point of view of the occurrence of residues of foreign substances in edible tissues, the administration of food-waste pastes to farm animals can be considered as admissible.

Animal Feed↗
PubMed1979

[Does nutrition influence the propagation of neoplasms?].

In the last years, questions concerning the relationship between nutrition and the occurrence of neoplasms have been studied more intensively. The author discusses the possible involvement of water as a potential carrier of certain cylic hydrocarbons and radionuclides, and of nutrition per se. He treats problems related to, inter alia, bulk materials, polyethenoid fatty acids, the increase in fat consumption, trace elements, vitamins and the importance of the intestinal flora.

Carcinogens↗
PubMed1978

Some recent findings in obesity.

The tendency of some obese subjects to an energy-sparing reaction can be induced temporarily by attempts of the patient to reduce his overweight by prolonged starvation. This regulatory reaction may be induced by regulatory especially thyroid mechanisms. In obesity of both sexes a tendency to anaerobic energy utilization in the muscle can be revealed and so a tendency to decrease energy utilization in general. The differences in insulinemia (IRI) displayed a prevalence of maternal obesity in the group with higher levels of basal and stimulated IRI values, which decline after changes in diet and body weight. This behavior of IRI levels and amount and composition of diet indicate a possible permissive role of previous food consumption habits.

Achilles Tendon↗