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Biomedical subjects

J Mathieu

Publications and source records attributed to J Mathieu.

At least 109 records · Page 6Linked to original sources
PubMed1988

Modulation of leucocyte activation in the early phase of the rabbit burn injury.

Previous studies in burned patients have shown an early enhanced polymorphonuclear leucocyte (PMN) generating capacity for superoxide radical (O2.-), for the arachidonic acid (AA) lipoxygenase metabolite leukotriene B4 (LTB4) and for platelet activating factor-acether (PAF). These findings have been confirmed on a burn injury rabbit model. As we have suggested a pivotal role for an exaggerated initial (less than 36-48 h) neutrophil stimulation leading to a later (greater than 72 h) immuno-depression and anergy, we tried to modulate the early phase by drug therapy. A Ginkgo biloba extract (IPS200) injected i.v. in burned rabbits greatly reduced O2.- and LTB4 generation on A23187 challenge. IPS200 includes flavonoids and other polyphenols, inhibiting either arachidonic acid metabolism or PAF receptors, and may thus exert their modulating effect on PMN function in thermal injury.

Animals↗
PubMed1988

[Spreading of the gene for myotonic dystrophy in Saguenay (Quebec)].

The prevalence of the myotonic dystrophy (Steinert disease) is about 1/475 in the Saguenay region, located in the North-east of the province of Québec (Canada). About 600 cases are currently known in a population of 285,000 inhabitants. This disease is an autosomal dominant disorder which causes a general muscular degeneration. Usually, it is also associated with a lower fertility, if not sterility, among the affected families. Another element of the phenotype is a higher infant mortality rate among cases. In the light of those traits, the very high prevalence of the disease in the Saguenay population becomes rather puzzling. It is the subject of this research. Using a computerized population register, we have been able to analyze the genealogies of the patients and their family history. In the overall, two basic factors account for the wide transmission of the gene: a) an immigration stream from a neighbouring region (Charlevoix) may have brought between 57 and 77 patients into the Saguenay since 1840; b) the cases proved to be by and large as fertile as controls (an average of 9.2 births among 85 affected families). The paper also presents a genealogical inference program used to ascertain cases among ancestors, along with data on the history of the gene, nuptiality, geographical and occupational mobility. In the overall, we have not been able to bring out an important selective disadvantage against the patients.

Female↗
PubMed1982

[Thermal stability of carbonates in bone tissue].

The analysis shows that carbonate ions present in the mineral phases of calcified tissues are decomposed in two steps during their ignition. These carbonate ions might be all localised in the phosphate sites of the apatitic structure (B type carbonate apatite). The loss of one important part of carbonate ions at a abnormally low temperature (250 degrees C) might result from an intracristalline reaction between these ions and HPO4(2-) or P2O7(4-) ions present in the apatitic structure.

Animals↗
PubMed1981

[Not Available].

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Canada↗
PubMed1980

Intermittent claudication of the hand after creation of an arteriovenous fistula in the forearm.

Eighty-five patients were followed up at least 1 year after creation of an arteriovenous fistula in the forearm. The anastomosis was side-to-side in 33 patients, end-to-side in 33 and end-to-end in 19. Trophic lesions were not observed. Intermittent claudication of the hand was more frequent in patients with a side-to-side arteriovenous fistula (42 percent) than in those with end-to-side (21 percent) or end-to-end fistulas (16 percent). Clinical and x-ray studies indicate that two different mechanisms are responsible for cramping pains: arterial steal phenomenon and venous hypertension. Their relative importance depends on multiple hemodynamic factors that may vary with time.

Adolescent↗
PubMed1980

Contribution of angiography in bladder cancer.

Pelvic angiography was performed in 24 patients with primary or secondary tumours. 17 patients were submitted to arteriography and 7 to phlebography of the pelvis veins. An angiographic classification was established and compared to the pre-operative and histopathological results determining tumour staging. These results were compared to those obtained by bimanual palpation under narcosis and demonstrated the significant contribution of angiography in determining the extravesical spreading of bladder tumours.

Adenocarcinoma↗
PubMed1980

Preoperative embolization of renal tumors--comparison of different methods.

Different techniques and materials for preoperative embolization of renal carcinoma have been assessed in 26 cases. The different methods used and compared were gelfoam fragments (10 cases), cyanoacrylate (4 cases), Gianturco stainless steel coil (3 cases) and the combination of gelfoam and the Gianturco device (9 cases). The method of choice appears to be the combination of gelfoam and the Gianturco device which allows excellent peripheral ischemia with complete occlusion of the main arterial trunks. Embolization is particularly useful in invading and hypervascularized renal tumors supplied by collateral blood vessels.

Bucrylate↗
PubMed1979

Acquired supravalvular aortic stenosis.

Severe supravalvular aortic stenosis was discovered at reoperation in 3 children with recurrent stenosis of the left ventricular outflow tract. The lesion consisted of gross thickening of the sinus ridge, most marked at the site of the previous aortotomy. The thickening had shortened the free edge of one or more leaflets and had distorted adjacent commissures. Preoperative angiography had indicated valve stenosis, but little commissural fusion was found at operation and the outflow tract obstruction was relieved by inserting a prosthetic patch in the ascending aorta. Recognition of this iatrogenic pathology is important to avoid supravalvular stenosis after aortic valvotomy and unnecessary valve replacement in children requiring reoperation for recurrent left ventricular outflow tract obstruction.

Adolescent↗
PubMed1977

Effect in vitro of ioglycamide on blood proteins and paraproteins.

No modification of plasma or serum viscosity was observed after in vitro addition of ioglycamide in a series of 160 healthy subjects and 1 467 patients including 33 cases of IgM paraproteinemia, 20 with Waldenström's disease. The labelled contrast medium never bound to paraproteins. These results are contradictory to the statements in the literature, that plasma gel formation occurs in Waldenström's disease.

Blood Proteins↗
PubMed1975

Sagittal mobility of the normal ankle.

In children and adults, there is a physiological anterior sagittal displacement of the talus which decreases when the examination is repeated in equinus. The displacement occurs when the examination is performed with or without apparatus, with manual stress or with weights. The diminution of the normal sagittal mobility of the talus when the examination is performed with the ankle in the position of equinus, it attributable to the intact anterior talofibular ligament which becomes taut when the ankle is in a position of flexion. A pathological drawer sign will be noted following an isolated tear of the anterior talofibular; under those circumstances sagittal instability is increased and is not appreciably affected by repeating the examination in a position of ankle equinus.

Adolescent↗