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Biomedical subjects

J Mattelaer

Publications and source records attributed to J Mattelaer.

At least 19 recordsLinked to original sources
PubMed1995

Prognostic factors in advanced prostatic carcinoma treated with total androgen blockade. Flutamide with orchiectomy or with LHRH analogues. A Belgian multicentric study of 546 patients.

Prognostic factors were evaluated in advanced loco-regional (M0) or distant metastatic (M1) prostatic carcinoma treated with total androgen blockade (flutamide with either orchiectomy of LHRH-analogues), in 546 patients from a Belgian multicentric study. After a mean follow-up of 16.5 months (maximum 37 months) 113 (21%) patients had progressed (90 were patients with M1 disease (31%)). The estimated median progression-free survival exceeded 37.5 months. The results of a univariate analysis show that the following parameters are important prognostic factors with respect to progression-free survival in these patients: M stage, G grade, ECOG performance status, weight loss, concomitant disease, pain, dysuria and haemoglobin (Lee-Desu test, p < or = 0.01). From a multivariate analysis (Cox regression) the following prognostic factors were indicative of a decrease in progression-free survival: M1 stage, high initial G grade, ECOG performance status > I, high serum PSA, presence of concomitant disease, presence of pain and absence of dysuria. Age did not appear to be a statistically significant prognostic factor.

Aged↗
PubMed1994

Endocrine profiles during administration of the new non-steroidal anti-androgen Casodex in prostate cancer.

OBJECTIVE: Casodex (Zeneca) is a new potent, long-acting non-steroidal anti-androgen, which produces androgen deprivation by blocking the androgen receptor. We evaluated the endocrine effects of Casodex 150 mg daily given in monotherapy as primary treatment for patients with prostate cancer. DESIGN: As part of a large, multicentre study comparing the therapeutic effects of surgical castration with 150 mg/day Casodex in monotherapy for patients with prostate cancer, a subgroup of 23 patients on Casodex were studied in detail for changes in endocrine parameters. Serum levels of LH, FSH, testosterone, DHT, oestradiol, prolactin, sex hormone binding globulin and free testosterone were measured at the start of therapy and after 1, 4, 8, 12 and 24 weeks. Effects on libido, sexual activity and the appearance of hot flushes, breast pain and gynaecomastia were recorded. RESULTS: Administration of Casodex resulted in a rise in LH levels in all patients with a mean increase after 24 weeks of 102% (P < 0.001). Mean FSH levels showed a limited increase (7%) after 24 weeks, which was significant only after 1 week (P < 0.001). As a result of the high LH levels, total testosterone levels increased after 24 weeks by 66% (P < 0.001), free testosterone by 57% (P < 0.001) and dihydrotestosterone by 24% (P = 0.0112). Parallel to testosterone, oestradiol levels rose by a mean of 66% (P < 0.001). Mean sex hormone binding globulin and prolactin levels rose by respectively 8% (P = NS) and 65% (P < 0.01). Despite an increase in testosterone levels, excellent androgen blockade was obtained, as shown by a decrease in prostate specific antigen levels in 22/23 patients. Libido was maintained in 8/11 patients, and sexual activity in 5/6. No patient complained of hot flushes. However, mild gynaecomastia and/or breast tenderness were seen in 48 and 30% of cases respectively. CONCLUSION: Casodex 150 mg/day monotherapy resembles surgical castration in achieving androgen deprivation, despite an increase in LH and testosterone levels. In contrast to castration, libido and sexual activity are usually maintained and hot flushes are rare. However, mild gynaecomastia and/or breast tenderness were noted in 48 and 30% of patients.

Aged↗
PubMed1994

Adenoid cystic carcinoma of the prostate.

A case of a patient with this extremely rare tumor is described. Adenoid cystic carcinoma of the prostate should be considered as a subtype of prostate adenocarcinoma. Since this tumor can be associated with a prostatic adenocarcinoma, it should be regarded as malignant.

Adenocarcinoma↗
PubMed1991

Endopyelotomy. Evaluation of a limited experience.

Endopyelotomy is a recently developed endo-urological technique which gets to be standardised and gradually may replace the open pyeloplasty. Our technique is described and the early results are presented.

Adolescent↗
PubMed1990

Use of transrectal longitudinal sonography in the placement of a prostatic coil.

Patients with acute or chronic urinary retention, not suitable for operation, no longer need permanent transurethral or suprapubic catheters. The prostatic coil is an excellent alternative. A series of 25 patients is presented. The technique of placement is described in detail as well as the use of longitudinal transrectal sonography in the preparation and follow-up of patients with a coil.

Equipment Design↗
PubMed1990

Fournier's gangrene. Report of three cases and review of the literature.

Fournier's gangrene, or synergistic gangrene of the male external genitalia is a rapidly spreading necrotising infection of the penis and scrotum. Although not so frequent in our civilized world it is by no means rare. In early days it was characterised by a high mortality. Aggressive surgical debridement, broad spectrum antibiotics and plastic reconstructive technics have all contributed to a better survival of the patients.

Aged↗
PubMed1990

Syringocele, a rare lesion of Cowper's gland.

Syringocele are retentioncysts of Cowper's glands. First described by Fenwick, Maizels rediscovered them and made a very usefull classification. These cysts are more common than previously reported. They can be very obstructive for the urinary flow or cause no symptoms at all. Most are congenital. In our series we studied 5 patients with syringoceles. Treatment consisted in broad endoscopic unroofing. The results with this type of surgery are good. Follow-up showed all the patients to void well and to be free of other irritative symptoms.

Adolescent↗
PubMed1988

Inverted papilloma of bladder: clinical significance.

Based on 15 cases of inverted urothelial papilloma, we present the clinical significance of these lesions in view of the current literature. An inverted papilloma should raise suspicion with respect to the whole urothelial surface. However, approaching every lesion of this type as a (pre-)neoplastic tumor does not seem justified, since 90 percent of all cases reported so far do not present any clinical or histologic feature of malignancy. Some factors, such as the patient's history, eventually associated urothelial carcinomas, or histologic features of malignant transformation within an inverted papilloma, must be taken into consideration. If no single indication in favor of malignancy has been disclosed, we believe follow-up with yearly endoscopic investigations, in addition to regular urine cytologies, may suffice.

Aged↗
PubMed1987

[Pipemidic acid in the prevention of recurring cystitis in women].

The efficacy, safety and acceptability of pipemidic acid in the treatment and the prophylaxis of cystitis in women have been evaluated. After curative treatment, patients received prophylaxis using the compound for a duration of 6 months, and were followed up a further 4 month-period without specific therapy. During the prophylaxis period, no relapse was observed in over 85% of the treated patients. In 15% of cases, a pathogen reappeared along with recurrence of the preexisting symptoms. An increase to 29% of the cases was noted after the withdrawal of the treatment over a month study period. The pathogens involved in the cases of relapse during the prophylaxis period were sensitive to pipemidic acid in 1/3 of cases (6/18 cases), and resistant in 2/3 (12/18 cases) of cases. Those involved in relapses during the observation period were sensitive in 1/2 of the cases (8/16 cases), resistant or intermediate in 1/2 of the cases (8/16 cases). Thus, prophylactic treatment with pipemidic acid has a favorable influence on the number of relapses in patients with recurrent cystitis.

Cystitis↗
PubMed1983

Treatment of chronic bacterial prostatitis by local injection of antibiotics into prostate.

Experiences with localized antibiotic treatment of chronic bacterial prostatitis by direct injection into the caudal prostate is presented. Very high antibiotic levels are found in the prostatic fluid without correlation with the time after injection. The pain and discomfort experienced by the patients during direct injection into the prostate are minimal. Hematuria and hemospermia during some weeks are practically always present after the injection. Local necrosis was not found after several histologic and electronic microscopic studies. Results demonstrated that this method deserves its place in the treatment of the hard-core group of chronic bacterial prostatitis.

Adult↗
PubMed1983

Prostatitis update.

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Anti-Bacterial Agents↗