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Biomedical subjects

J Mauss

Publications and source records attributed to J Mauss.

At least 19 recordsLinked to original sources
PubMed1992

[Patients with severe multiple handicaps in workshops for the handicapped--a project of the Berlin Workshops for the Handicapped GmbH (BWB) 4 December 1989 to 31 May 1990].

A project had been carried out at Berliner Werkstätten für Behinderte GmbH (BWB) aimed at integrating cerebral palsied persons with very severe, multiple disability in a workshop for the disabled. Client workshop readiness had been determined on the criteria of social capacity, extraordinary care need at the workplace, and economic viability of work. The project, planned to last 6 months, had to be discontinued because the 9 disabled persons included in this programme refused to cooperate after a short period of time.

Activities of Daily Living↗
PubMed1991

Unsteady wall shear stress in a distensible tube.

An asymptotic expression of the wall shear stress (WSS) in an elastic tube is deduced for small values of the Womersley parameter. In the case of a rigid tube this asymptotic expression is shown to compare better with the exact solution than Poiseuille's or Lambossy's approximations. Its integration in a one-dimensional model of the internal carotid artery blood flow predicts more marked systolic and less marked diastolic WSS than those predicted by the commonly used Poiseuille's approximation.

Carotid Artery, Internal↗
PubMed1979

Endocrine testicular function in vivo and in vitro in infertile men.

In order to detect any possible Leydig cell dysfunction associated with male infertility, the endocrine capacity of the tests was investigated in vivo and in vitro in 21 infertile men. Plasma testosterone was determined before and after 3 days of hCG stimulation. Testicular tissue obtained by bilateral biopsies was subjected to (1) histological examination, (2) determination of basal testosterone concentration and (3) incubation with hCG. Patients were grouped according to histology. In vitro basal and stimulated testicular testosterone was similar in patients with normal histology, Sertoli-cell-only syndrome and spermatogenic arrest. Tissue from patients with Leydig cell hyperplasia showed 3-fold higher basal testosterone levels and a greater response to hCG. All patients had plasma testosterone levels and responses to hCG in the normal range. There was no significant correlation between the data obtained in vivo and in vitro, indicating that testosterone determinations in peripheral blood do not necessarily reflect the intratesticular situation. There was no evidence for gross abnormality in Leydig cell function accompanying disturbed spermatogenesis.

Adolescent↗
PubMed1977

[Oligozoospermia in Klinefelter's syndrome].

Case report of a 31 year old male with a 47-XXY-Klinefelter-syndrome which showed a maximum of 4,0 million spermatozoa/ml with a motility of up to 51% in his ejaculate. No rise of spermatozoa counts could be observed after 3x25 mg mesterolone/day over 8 weeks.

Adult↗
PubMed1975

[Exo- and endocrine testicular function in the aging man].

In males over 60 years of age FSH excretion remains within the same range, whilst LH secretion increases significantly. Plasma testosterone and the biological active testosterone fraction decreases whilst at the same time the percentage of protein bound biological inactive testosterone increases. The androgen dependent target tissues become less sensitive to testosterone. The metabolic clearance rate for testosterone decreases. Spermatogenesis seems to stay intact in male senescence but exhaustive research in this field is not available.

Adult↗
PubMed1975

The role of testosterone in the feedback control of male FSH and LH secretion.

Intramuscular administration of 250 mg testosterone oenanthate per week over a period of 21 weeks treatment rapidly and sustainedly suppressed serum LH as well as FSH levels in seven normal males, while serum testosterone rose by a factor of approximately two. These together with other data provide increasing evidence for a feedback control of FSH secretion by gonadal steroids in the male in addition to the already described but as yet undefined tubular testicular factor.

Adult↗
PubMed1975

Effect of long-term testosterone oenanthate administration on male reproductive function: clinical evaluation, serum FSH, LH, testosterone, and seminal fluid analyses in normal men.

The effect of long-term testosterone administration on male reproductive function has been investigated in seven healthy young men age 20 to 27 years. Testosterone oenanthate (TOe) was administered in doses of 250 mg per week for 21 weeks. No toxic side-effects were observed. Libido, sexual potency, frequency of sexual intercourse and body hair development generally remained unaffected, but there was a reversible mean weight gain of 3.6 kg during TOe administration. Seminal fluid parameters and radioimmunoassayable serum FSH, LH, testosterone, and androstenedione levels were monitored before, during, and after TOe administration. The serum testosterone rose approximately by a factor of two, while the serum FSH and LH were rapidly suppressed after the initiation of the TOe therapy. The mean sperm concentration fell to values below three million spermatozoa per ml, and changes in sperm motility, the percentage of normal sperm morphology, and seminal fructose concentrations generally paralleled those of the mean sperm concentrations. In contrast, the mean seminal fluid volume and serum androstenedione levels did not change significantly during TOe administration. The mean sperm concentration showed a marked recovery 13 to 16 weeks after TOe withdrawal, but sperm counts remained below pre-treatment levels in three out of seven subjects 25 to 28 weeks after discontinuation of TOe.

Adult↗
PubMed1975

Plasma androgen levels in men after oral administration of testosterone or testosterone undecanoate.

Plasma testosterone and androstenedione levels in men were measured after oral administration of free testosterone and testosterone undecanoate. Both androgens were determined by simultaneous, specific radioimmunoassays after separation and isolation by thin layer chromatography. While free unesterified testosterone had no effect on plasma androgen levels, a striking increase of both testosterone and androstenedione levels was noted after administration of testosterone undecanoate, which is otherwise only achieved by parenteral testosterone application. This effect of testosterone undecanoate is probably due to absorption via the lymph rather than via the portal vessels so that peripheral circulation is reached before metabolism in the liver. Testosterone undecanoate promises to be an effective medication for oral androgen replacement.

Adolescent↗
PubMed1975

[Light and electron microscopy studies on malformed spermatids in 2 cases of teratozoospermia].

Two distinct types of spermatid malformation resulting in teratozoospermia are demonstrated in two patients by means of light and electron microscopy. In one case of male infertility, a disturbance of the process of nuclear condensation was found which yielded pathological spermatozoa with triangular or hookshaped heads. In another case of infertility, exclusively polynucleated spermatids were detected. Atypical acrosomes, showing widely varying structural features, interconnect the nuclei. The significant of these malformations for the understanding of the differentiation of spermatids is discussed.

Biopsy↗